646 pages | 200 Color Illus.
The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data.
Section 1: Background and epidemiology. History of the European Society of Hypertension: Past, Present and Future. Hypertension as a cardiovascular risk factor. Hypertension and the kidney. Blood pressure control in Europe and elsewhere. Socioeconomic determinants. Section 2: Etiological and pathophysiological aspects. Hemodynamic patterns in hypertension. Genetic basis of blood pressure and hypertension. Oxidative stress, inflammation, immune system and hypertension. Sodium and potassium. Structural cardiovascular changes in hypertension. Early Vascular Ageing. Autonomic dysfunction. The renin angiotensin aldosterone system. Stress, stress reduction and hypertension: an updated review. Section 3: Associated risk factors. Pathogenetic role and risk modification. Heart Rate as a cardiovascular risk factor in hypertension. Obesity and obstructive sleep apnoea. The metabolic syndrome in hypertension. Psychosocial risk factors, airborn pollution, hypertension and cardiovascular diseases. Serum uric acid, blood pressure and hypertension. Dyslipidaemia in hypertension. Section 4: BP measurements. Old and new office blood pressure measurement approaches. Pulse pressure. Central Blood Pressure. Ambulatory Blood Pressure Measurement. Home Blood Pressure. Day-night related events: night-time blood pressure fall and morning blood pressure rise. Short-term Blood Pressure Variability. Exercise Blood Pressure: The prognostic impact of exercise systolic blood pressure. Section 5: Organ damage- measurement/clinical value. Cardiac damage from left ventricular hypertrophy to heart failure. Structural and functional aspects of brian damage. Large arteries damage: measurement and clinical importance. Microcirculation. Endothelial Damage. Retinal changes. Section 6: Integrated diagnostic aspects. The integrated diagnostic approach in general medicine. Management of Hypertension by the Hypertension Specialist and the Hypertension Excellence Centers. Section 7: Therapeutic aspects. Non pharmacological interventions. The protective cardiovascular effects of antihypertensive treatment. The nephroprotective effect of antihypertensive treatment. Antihypertensive Drug Classes. Single pill combination treatments in hypertension. The J-curve phenomenon. A polypill for global cardiovascular prevention: current data and future perspectives. Managing adverse effects and drug intolerance. Adherence to treatment in hypertension. Residual risk in treated patients. Section 8: Special conditions. Ethnic factors in hypertension. Resistant hypertension: medical treatment. Interventional therapies for essential hypertension. Atrial Fibrillation and Arterial Hypertension. The diabetic/obese hypertensive patient (includes the metabolic syndrome). Hypertension in children and adolescents. Hypertensive emergencies and urgencies. Hypertension associated to peripheral artery disease (PAD). Hypertension in pregnancy. Drug induced hypertension. Hypertension in patients with advanced chronic kidney disease. Blood pressure management in acute stroke. Blood pressure management in the chronic post-stroke phase. The post-transplant patient with hypertension. Section 9: Secondary hypertension. Diagnosis and treatment. Renovascular hypertension. Primary Aldosteronism. Pheochromocytoma and paraganglioma. Section 10: Additional aspects. Follow-up of the hypertensive patient. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Index