Marine Biomaterials : Characterization, Isolation and Applications book cover
1st Edition

Marine Biomaterials
Characterization, Isolation and Applications

Edited By

Se-Kwon Kim

ISBN 9781138076389
Published March 29, 2017 by CRC Press
840 Pages 244 B/W Illustrations

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Book Description

Oceans are an abundant source of diverse biomaterials with potential for an array of uses. Marine Biomaterials: Characterization, Isolation and Applications brings together the wide range of research in this important area, including the latest developments and applications, from preliminary research to clinical trials. The book is divided into four parts, with chapters written by experts from around the world. Biomaterials described come from a variety of marine sources, such as fish, algae, microorganisms, crustaceans, and mollusks.

Part I covers the isolation and characterization of marine biomaterials—bioceramics, biopolymers, fatty acids, toxins and pigments, nanoparticles, and adhesive materials. It also describes problems that may be encountered in the process as well as possible solutions. Part II looks at biological activities of marine biomaterials, including polysaccharides, biotoxins, and peptides. Chapters examine health benefits of the biomaterials, such as antiviral activity, antidiabetic properties, anticoagulant and anti-allergic effects, and more.

Part III discusses biomedical applications of marine biomaterials, including nanocomposites, and describes applications of various materials in tissue engineering and drug delivery. Part IV explores commercialization of marine-derived biomaterials—marine polysaccharides and marine enzymes—and examines industry perspectives and applications. This book covers the key aspects of available marine biomaterials for biological and biomedical applications, and presents techniques that can be used for future isolation of novel materials from marine sources.

Table of Contents

Part I: Isolation and Characterization of Marine Biomaterials

Introduction to Marine Biomaterials
Se-Kwon Kim and Jayachandran Venkatesan

Hydroxyapatite from Marine Fish Bone: Isolation and Characterization Techniques
Jayachandran Venkatesan and Se-Kwon Kim

Hydroxyapatite and Calcium Phosphates from Marine Sources: Extraction and Characterization
Clara Piccirillo, Manuela M. Pintado, and Paula M.L. Castro

Isolation and Characterization of Chitin and Chitosan as Potential Biomaterials
Nitar Nwe, Tetsuya Furuike, and Hiroshi Tamura

Structure Elucidation and Biological Effects of Carrageenans from Red Algae
Wei Zhang, Ming Liu, and Poul Erik Hansen

A Study of Marine-Derived Fatty Acids and Their Therapeutic Importance
Parimal C. Sen

Marine Toxins for Natural Products Drug Discovery
Muthuvel Arumugam, Thangavel Balasubramanian, and Se-Kwon Kim

Conotoxins: A Source of Biomaterial for Pharmacology and Neuroscience
Ngo Dang Nghia

Pigmented Marine Heterotrophic Bacteria: Occurrence, Diversity, and Characterization of Pigmentation
Marit H. Stafsnes and Per Bruheim

Antitumor Pigments from Marine Bacteria
Azamjon B. Soliev and Keiichi Enomoto

Structural Characteristics of Bioactive Marine Natural Products
Snezana Agatonovic-Kustrin, David Morton, and Christine Kettle

Environmental and Human Impact on Marine Microorganism–Synthesized Nanoparticles
L. Karthik, Gaurav Kumar, and K.V. Bhaskara Rao

Biosynthesis and Characterization of Different Nanoparticles and Its Larvicidal Activity against Human Disease Vectors
Arivarasan Vishnu Kirthi, Chidambaram Jayaseelan, and Abdul Abdul Rahuman

Mussel-Derived Adhesive Biomaterials
Dong Soo Hwang, Yoo Seong Choi, and Hyung Joon Cha

Part II Biological Activities of Marine Biomaterials

Biological Applications of Marine Biomaterials
A. Malshani Samaraweera and Janak K. Vidanarachchi

Health Benefits of Sulfated Polysaccharides from Marine Algae
Se-Kwon Kim, Dai-Hung Ngo, Thanh-Sang Vo, and Dai-Nghiep Ngo

Biological Activities and Potential Applications of Marine Biotoxins
Alberto Otero, María José Chapela, Jorge Lago, Juan M. Vieites, and Ana G. Cabado

Compounds from Marine Organisms with Antiviral Activity
Se-Kwon Kim, Fatih Karadeniz, and Mustafa Zafer Karagozlu

Biological Activities of Marine-Derived Bioactive Peptides
Chen Zhang, Yuanfeng Ruan, and Se-Kwon Kim

Health Beneficial Effects of Docosahexaenoic Acid: A Marine Treasure
Na-Young Song and Young-Joon Surh

Treatment of Obesity and Diabetes with Marine-Derived Biomaterials
Se-Kwon Kim, Fatih Karadeniz, and Mustafa Zafer Karagozlu

Potential Anticoagulant Effect of Seaweed-Derived Biomaterials
Se-Kwon Kim and Quang Van Ta

Microbial Biomaterials and Their Applications
Se-Kwon Kim, Ira Bhatnagar, and Ramjee Pallela

Marine Biomaterials for Antiallergic Therapeutics
Se-Kwon Kim, Thanh-Sang Vo, and Dai-Hung Ngo

Part III Biomedical Applications of Marine Biomaterials

Biomedical Potential of Unchlorinated Briarane Diterpenes from Gorgonians and Sea Pens
Bruce F. Bowden and Ioana M. Vasilescu

Application of Marine Collagen-Based Scaffolds in Bone Tissue Engineering
Ramjee Pallela, Jayachandran Venkatesan, Ira Bhatnagar, Yoon-Bo Shim, and Se-Kwon Kim

Biocomposites Containing Chitosan for Bone Tissue Engineering
Sekaran Saravanan, Mohita Trivedi, Ambigapathi Moorthi, and Nagarajan Selvamurugan

Marine Plants and Algae as Promising 3D Scaffolds for Tissue Engineering
M. López-Álvarez, J. Serra, J.M. Sánchez, A. de Carlos, and P. González

Application of Marine Biomaterials in Orthopedic and Soft Tissue Surgical Challenges
Samit Kumar Nandi, Uttam Datta, and Subhasish Biswas

Marine Materials in Drug Delivery and Tissue Engineering: From Natural Role Models to Bone Regeneration and Repair and Slow Delivery of Therapeutic Drugs, Proteins, and Genes
Besim Ben-Nissan and David W. Green

Polysaccharides from Seaweeds: Modification and Potential Application in Drug Delivery
Héctor J. Prado, María C. Matulewicz, Pablo R. Bonelli, and Ana L. Cukierman

Marine Biomaterials: Role in Drug Delivery and Tissue Engineering toward Biomedical Applications
Devarai Santhosh Kumar and Kota Sobha

Application of Marine Biomaterials for Gene Delivery
You-Kyoung Kim, Hu-Lin Jiang, Bijay Singh, Yun-Jaie Choi, Myung-Haing Cho, Toshihiro Akaike, and Chong-Su Cho

Advantages of Chitin-Based Nanobiomaterials in Nanomedicine
S. Sowmya, Shantikumar V. Nair, and R. Jayakumar

Chitin Nanofibrils for Biomimetic Products: Nanoparticles and Nanocomposite Chitosan Films in Health Care
P. Morganti, G. Tishchenko, M. Palombo, I. Kelnar, L. Brozova, M. Spirkova, E. Pavlova, L. Kobera, and F. Carezzi

Role of Nanocomposites and Nanostructured Biomaterials in Biomedical and Nanobiotechnology
Abdul Bakrudeen Ali Ahmed, R. Arun Kumar, and Rosna Mat Taha

Part IV: Industrial Applications of Marine-Derived Biomaterials

Industry Perspectives of Marine-Derived Proteins as Biomaterials
Se-Kwon Kim, Dai-Hung Ngo, Thanh-Sang Vo, and BoMi Ryu

Marine Polysaccharide (Chitosan) and Its Derivatives as Water Purifier
Y. Dominic Ravichandran and R. Rajesh

Industrial Applications of Marine Polysaccharides
S.N. Joshi, A.N. Bedekar, and P.N. Sudha

Application of Enzymes from Marine Microorganisms
Xiujuan Shi, E. Song, and Chen Zhang


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Professor Se-Kwon Kim, Ph.D., is a senior professor in the Department of Chemistry and is the director of the Marine Bioprocess Research Center (MBPRC) at Pukyong National University in the Republic of Korea. His major research interests include investigation and development of bioactive substances derived from marine organisms and their application in Oriental medicine, nutraceuticals, and cosmeceuticals via marine bioprocessing and mass-production technologies. He is a board member of the International Society of Marine Biotechnology and the International Society for Nutraceuticals and Functional Foods. To date, he has authored more than 500 research papers, holds 110 patents, and has written or edited more than 40 books.


"… stuffed with best and recent information, techniques, delivers good ideas and motivates for further research and forecasts future activity in the marine renewable sectors on specified topics. Essential reading …"
—Dr. P.N.Sudha, D.K.M. College for Women, Tamilnadu, India

"… should be on the shelf of every university library and laboratory actively involved in Marine Biomaterials research. The book will inspire the new scientists and will continue to be a useful reference material for many years."
—Vassilios Roussis, University of Athens, Greece

"… includes several interrelated topics associated with development and use of marine biomaterials including isolation, characterization, biological activity, medical use, and industrial use. … a strong effort … "
—Roger Narayan, UNC/NCSU Joint Department of Biomedical Engineering, Raleigh, North Carolina, USA

After the 2011 publication Chitin, Chitosan, Oligosaccharides and Their Derivatives, and the 2012 Marine Cosmeceutical, both edited by professor Se-Kwon Kim, this third book… represents another precious source of ideas useful for increasing the knowledge on chitins and the other interesting raw materials obtained from the sea …"
––The Journal of Applied Cosmetology, 2013

"This is an extremely informative and thoroughly referenced volume that covers essentially all aspects of the various stages involved in the commercialisation of a broad range of marine-derived bio-materials, beginning with isolation and characterisation, through assessing bioactivity, to specific applications. It is therefore highly recommended to individuals, both in academia and industry, with interests in any aspects of the isolation, identification, testing, and application of marine-derived biomaterials ..."
—Charles J. Knill and John F. Kennedy, Chembiotech Laboratories, Tenbury Wells, UK, from International Journal of Biological Macromolecules, September 2015