Marine Biomedicine: From Beach to Bedside assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field.
Richly illustrated in full color to enhance reader comprehension, the book covers four sections. The first one addresses the technology that has recently been brought to bear on the study of marine natural products, including omics and bioinformatic techniques. The second focuses on lead discovery and reviews various products and their biomedical potential.
Examples of clinically successful marine products and discussions of approaches to the clinic are presented in the third section while the last section discusses prospects for the future of marine biodiscovery.
Highlighting new technologies, this valuable resource provides an overview of both what is currently possible in the field as well as a detailed look at what is being done in marine natural products research.
Table of Contents
MARINE BIOTECHNOLOGY: INFORMING THE SEARCH. Accessing Chemical Diversity through Metagenomics. Chemical Characterization of Marine Organisms Using a Metabolomic Approach. Biosynthetic Approaches to Marine Drug Discovery and Development. Dereplication of Natural Products Using Databases. MARINE BIODISCOVERY: LEAD DISCOVERY. Logistic Considerations to Deliver Natural Product Libraries for High-Throughput Screening. Screening Marine Microbial Libraries. Screening Strategies for Drug Discovery and Target Identification. Anti-Infective Agents from Marine Sources. Screening for Antiparasitic Marine Natural Products. Central Nervous System Modulators from the Oceans. Marine Organisms in Cancer Chemoprevention. Off the Beaten Path: Natural Products from Extreme Environments. Bioprospecting Fungi and the Labyrinthulomycetes at the Ocean-Land Interface. Medicinal Chemistry and Lead Optimization of Marine Natural Products. MARINE PRODUCTS IN BIOMEDICINE. The Travails of Clinical Trials with Marine-Sourced Compounds. Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications. Development and Commercialization of a Fully Synthetic Marine Natural Product Analogue, Halaven (Eribulin Mesylate). Marine Natural Products in Pharma: How Industry Missed the Boat. In Vitro Model for Defining Neurotoxicity of Anticancer Agents. PROSPECTS FOR THE FUTURE OF MARINE BIODISCOVERY.
Comments on the Past and Future of Marine Natural Product Drug Discovery.
Bill J. Baker is a professor of chemistry and director of University of South Florida’s Center for Drug Discovery and Innovation in Tampa. He earned a BS in chemistry from Cal Poly in San Luis Obispo, California, and his PhD from the University of Hawaii. Dr. Baker conducted postdoctoral research with Ron Parry at Rice University and Carl Djerassi at Stanford University. He is currently visiting Beaufort professor of marine biodiscovery at the National University of Ireland Galway. His research interests in marine natural product chemistry have taken him all over the globe, including 12 field seasons of research in Antarctica.
"This book is a most welcome treatise on the various aspects of discovering and developing medicines from marine organisms. [It] is a well-written and well-edited book, with excellent figures and overall production values. It is a must-read for anyone in or contemplating entry into the field of marine natural products. There is also insight and value here for drug discovery and medicinal chemistry groups in the pharmaceutical and biotechnology industries."
--John H. Cardellina, II, ReevesGroup Virginia Beach, Virginia, United States