Marine Biomedicine: From Beach to Bedside, 1st Edition (Hardback) book cover

Marine Biomedicine

From Beach to Bedside, 1st Edition

Edited by Bill J. Baker

CRC Press

594 pages | 92 Color Illus. | 184 B/W Illus.

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pub: 2015-11-06
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Description

Marine Biomedicine: From Beach to Bedside assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field.

Richly illustrated in full color to enhance reader comprehension, the book covers four sections. The first one addresses the technology that has recently been brought to bear on the study of marine natural products, including omics and bioinformatic techniques. The second focuses on lead discovery and reviews various products and their biomedical potential.

Examples of clinically successful marine products and discussions of approaches to the clinic are presented in the third section while the last section discusses prospects for the future of marine biodiscovery.

Highlighting new technologies, this valuable resource provides an overview of both what is currently possible in the field as well as a detailed look at what is being done in marine natural products research.

Reviews

"This book is a most welcome treatise on the various aspects of discovering and developing medicines from marine organisms. [It] is a well-written and well-edited book, with excellent figures and overall production values. It is a must-read for anyone in or contemplating entry into the field of marine natural products. There is also insight and value here for drug discovery and medicinal chemistry groups in the pharmaceutical and biotechnology industries."

--John H. Cardellina, II, ReevesGroup Virginia Beach, Virginia, United States

Table of Contents

MARINE BIOTECHNOLOGY: INFORMING THE SEARCH

Accessing Chemical Diversity through Metagenomics

Leah C. Blasiak and Russell T. Hill

Chemical Characterization of Marine Organisms Using a Metabolomic Approach

Kashif Ali, Robert Verpoorte, Erica G. Wilson, and Young Hae Choi

Biosynthetic Approaches to Marine Drug Discovery and Development

Eric W. Schmidt

Dereplication of Natural Products Using Databases

Hartmut Laatsch

MARINE BIODISCOVERY: LEAD DISCOVERY

Logistic Considerations to Deliver Natural Product Libraries for High-Throughput Screening

Ngoc B. Pham, Stephen Toms, David Camp, and Ronald J. Quinn

Screening Marine Microbial Libraries

Jacqueline L. von Salm, Christopher G. Witowski, Danielle H. Demers, Ryan M. Young, Laurent Calcul, and Bill J. Baker

Screening Strategies for Drug Discovery and Target Identification

Fatma H. Al-Awadhi, Lilibeth A. Salvador, and Hendrik Luesch

Anti-Infective Agents from Marine Sources

Cedric Pearce

Screening for Antiparasitic Marine Natural Products

Ryan M. Young and Eva-Rachele Pesce

Central Nervous System Modulators from the Oceans

Kh. Tanvir Ahmed, Neil Lax, and Kevin Tidgewell

Marine Organisms in Cancer Chemoprevention

Eun-Jung Park, Anam Shaikh, Brian T. Murphy, and John M. Pezzuto

Off the Beaten Path: Natural Products from Extreme Environments

Samantha M. Gromek, Ashley M. West, and Marcy J. Balunas

Bioprospecting Fungi and the Labyrinthulomycetes at the Ocean-Land Interface

Ka-Lai Pang, Clement K. M. Tsui, E. B. Gareth Jones, and Lilian L. P. Vrijmoed

Medicinal Chemistry and Lead Optimization of Marine Natural Products

James W. Leahy

MARINE PRODUCTS IN BIOMEDICINE

The Travails of Clinical Trials with Marine-Sourced Compounds

David J. Newman and Gordon M. Cragg

Conopeptides, Marine Natural Products from Venoms: Biomedical Applications and Future Research Applications

Baldomero M. Olivera, Helena Safavi-Hemami, Martin P. Horvath, and Russell W. Teichert

Development and Commercialization of a Fully Synthetic Marine Natural Product Analogue, Halaven (Eribulin Mesylate)

Charles E. Chase, Hyeong-wook Choi, Atsushi Endo, Francis G. Fang, and John D. Orr

Marine Natural Products in Pharma: How Industry Missed the Boat

Guy T. Carter and Valerie S. Bernan

In Vitro Model for Defining Neurotoxicity of Anticancer Agents

Balanehru Subramanian, Halina Pietraszkiewicz, Joseph E. Media, and Frederick A. Valeriote

PROSPECTS FOR THE FUTURE OF MARINE BIODISCOVERY

Comments on the Past and Future of Marine Natural Product Drug Discovery

William Fenical

About the Editor

Edited by

Bill J. Baker is a professor of chemistry and director of University of South Florida’s Center for Drug Discovery and Innovation in Tampa. He earned a BS in chemistry from Cal Poly in San Luis Obispo, California, and his PhD from the University of Hawaii. Dr. Baker conducted postdoctoral research with Ron Parry at Rice University and Carl Djerassi at Stanford University. He is currently visiting Beaufort professor of marine biodiscovery at the National University of Ireland Galway. His research interests in marine natural product chemistry have taken him all over the globe, including 12 field seasons of research in Antarctica.

Subject Categories

BISAC Subject Codes/Headings:
MED004000
MEDICAL / Alternative Medicine
SCI013000
SCIENCE / Chemistry / General
SCI039000
SCIENCE / Life Sciences / Biology / Marine Biology
SCI086000
SCIENCE / Life Sciences / General