132 Pages 25 B/W Illustrations
    by CRC Press

    This book represents the first compilation of the major research findings regarding Maspin—a mammary serpin (or serine) protease inhibitor. Maspin was originally discovered through subtractive hybridization and differential display analyses, comparing the differences in gene expression in normal mammary epithelium and invasive carcinoma cells. This work originated in the laboratory of Dr. Ruth Sager, a world-renowned geneticist, at the Dana Farber Cancer Institute and Harvard Medical School. The first introduction of Maspin to the research community occurred as a report in Science (v263:526-529, 1994), and described the unique tumor-suppressing activity of this novel gene in human mammary epithelial cells.

    Preface 1. Ruth Sager, Geneticist 2. Maspin in the Sager Laboratory 3. Maspin: Functional Insights from a Structural Perspective 4. Maspin and Myoepithelial Cells 5. Maspin and Pericellular Plasminogen Activationin Cell-Matrix Interaction 6. Genetic and Epigenetic Regulation of Maspin Gene Expression in Normal and Tumor Tissue 7. Maspin Suppresses Breast Cancer Cell Invasiveness by Modulating Integrin Expression and Function 8. The Role of Maspin in Tumor Progression and Normal Development 9. The Role of Maspin in Human Placental Development 10. Maspin, a Potential Prognostic Marker for Human Cancers


    Mary J.C. Hendrix, Department of Anatomy and Cell Biology Holden Comprehensive Cancer Center The University of Iowa Iowa City, Iowa, U.S.A.