This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.
Table of Contents
Aspartic Acid Racemization. Introduction to Aspartic Acid Racemization. Aspartic Acid Racemization on Aging. Aspartic Acid Racemization and Aging in Cartilaginous Tissue. Racemization and isomerization of Aspartyl Residues in Amyloid Peptides Involved in the Development of Alzheimer´s Disease. Aspartic Acid Racemization: Applications to Forensic and Archaeological Age Estimation. Advanced Glycation Endproducts. Advanced Glycation Endproducts: An Introduction. Advanced Glycation and Aging. AGE-RAGE Axis in the Aging and Diabetic Heart: Prime Target for Adjunctive Therapeutic Intervention. Advanced Glycation Endproducts in Aging Skin. Advanced Glycation Endproducts and Neurological Diseases. Advanced Glycation Endproducts for Age at Death Estimation. Telomeres. Introduction to Telomere Biology. Role of Telomeres in Aging. Telomeres and Cardiovascular Disease: Facts, Controversies and Limitations. Telomeres in Cancer. Forensic Application of Telomere Shortening in Age-at-death Estimation. Mitochondrial DNA Mutations. Introduction to Mitochondria Biology. Mitochondrial DNA Mutations and Aging. Mitochondrial DNA Mutations and Mitochondrial Diseases. Reproductive Approaches to Prevent the Transmission of Mitochondrial Diseases. Mitochondrial DNA Mutations and Neurodegenerative Diseases. An Overview of mtDNA Analysis for Age-at-death Estimation in Forensic Sciences. Epigenetics. Epigenetics: Its Role in Aging, Diseases and Biological Age Estimation.