282 Pages
by
CRC Press
The progressive growth of a malignant tumor is accompanied by a decline in the immune response, through mechanisms that have, until recently, been poorly understood. The new era of biological therapies, including cytokines, adoptive transfer of TIL cells, gene therapy and others, brought forth the need to understand the impact of the tumor on the immune system. Moreover, the inability to achieve... Read more
HLA and Cancer. HLA Class I Antigen Downregulation in Malignant Melanoma. Altered Expression of Tumor Antigens. Lack of Sufficient B7 Expression as a Tumor Escape Mechanism. Dendritic Cell Dysfunction in Cancer. Tumor-Induced Dendritic Cell Dysfunction. Alteration of Macrophage Functions During Mammary Tumor Development. Alteration in T Cell Signal Transduction in Cancer. Functional Alterations of T Cells in Patients with Cancer. Macrophage-Mediated Suppression of T and NK Cell Cytolytic, and Proliferative Activity: Emerging Mechanisms. FAS/FAS Ligand and Tumor Immunity. Killer Inhibitory Receptors in Natural Killer and T Lymphocytes. Suppressor T Cells and the Adoptive Immunotherapy of Tumors.
Biography
A Ochoa
