Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging.
The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion.
Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.
Basic Science Tools for Mechanobiology Research. An Introductory Guide to Solid Mechanics. Fluid Mechanics. Molecular Analysis in Mechanobiology. Cadiovascular Systems. Effects of Endovascular Intervention on Vascular Smooth Muscle Cell Function. Effects of Pressure on Vascular Smooth Muscle Cells. Mechanobiology of Heart Valves. Mechanobiology of Cardiac Fibroblasts. Mechanobiological Evidence for the Control of Neutophil Activity. Stress.Skeletal Mechanobiology. Mechanical Control of Bone Remodeling. Cell Mechanobiology. Pulmonary Vascular Mechanobiology. Lung Echanobiology. Mechanical Signaling. Mechanobiology of Bladder Urothelial Cells. The Mechanobiology of Aqueous Humor Transport across Schlemm's Canal Endothelium. Mechanobiology in Health and Disease in the Central Nervous System. Mechanostimulation in Bone and Tendon Tissue Engineering. Mechanobiology in the Stem Cell Niche. Mesenchymal Stem Cell Mechanobiology. The Use of Microfluidic Technology in Mechanobiology Research. Design of Abdominal Wall Hernioplasty Meshes Guided by Mechanobiology and the Wound Healing Response.Statistical Analysis. Design of Experiments and Optical Techniques.