Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing  book cover
1st Edition

Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing

  • Available for pre-order on June 15, 2023. Item will ship after July 6, 2023
ISBN 9780367775018
July 6, 2023 Forthcoming by CRC Press
312 Pages 44 Color & 147 B/W Illustrations

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Book Description

This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented.The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large scale mechanochemistry can meet industrial demands especially in the pharmaceutical industry. The case studies conducted on MOF Technologies and Deasyl demonstrate how mechanochemistry is employed on a pilot plant scale.


  • Mechanochemistry is rapidly developing as a multidisciplinary science on the borderline between chemistry, materials science and environmental science.
  • This unique text focuses on mechanochemistry with the ability to scale up and illustrates how mechanochemical synthesis is no longer an obstacle.
  • Timely and highlights recent advancements describing what can be achieved in chemical synthesis.
  • Mechanochemistry enables the synthesis of multiple polymorphic crystalline forms in the production of drugs in the form of tablets or granules in capsules.
  • The case studies conducted on MOF Technologies and Deasyl demonstrate how mechanochemistry is employed on a pilot plant scale.

Table of Contents

Introduction – overview of book – objective of book: Scaling up sustainable synthesis by mechanochemistry

Deborah Crawford, Felipe Garcia and Evelina Colacino

Mechanochemistry: a brief historical introduction

Seplak Vladimir and Senna Mamoru

Mechanochemistry – A general introduction : Mechanochemical Based Technologies

  1. In situ monitoring of mechanochemical reaction by Raman/PXRD
  2. Ivan Halasz

  3. Kinetics and thermodynamics of mechanochemical reactions: a computational approach
  4. Feliu Maseras

  5. The Thermodymanics and Kinetics of Mechanochemical Reactions: An experimental Approach
  6. Adam Michalchuk

  7. Life cycle assessment
  8. Sabrina Spatari

  9. Intellectual properties in mechanochemistry
  10. Tanja Benele

    Solvent-free Sustainable Technologies at large scale

  11. Mechanochemistry at scale: the ultimate process intensification and beyond including continuous mechanochemical synthesis by twin screw extrusion Identification of important parameters moving forward
  12. Valerio Isoni

  13. Batch mechanochemical synthesis – scale-up
  14. Michael Fellderhoff

  15. Acoustic synthesis (solvent-free) and Resonant Acoustic Mixing (RAM)
  16. Maria Rivas-Velazco

    Case studies/perspective

  17. Case Study: Sustainable large scale manufacturing of fine chemicals, APIs and biologically active compounds
  18. Bela Torok

  19. Case Study - Siebtechnik Company (DE) and eccentric mills
  20. Peter Balaz

  21. Scalable solutions for continuous manufacturing by mechanochemical-assisted synthesis
  22. Duncan Browne

    Reduced Solvent Sustainable Technologies

  23. Large Scale Continuous Flow Chemistry
  24. Darren Riley

  25. Sustainable chemical manufacture in water – An industrial point of view

Fabrice Gallou

Annex - Terminology and Nomenclature in Mechanochemistry


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Evelina Colacino received her double Ph.D. (with European Label) in 2002 at the University of Montpellier II (France), and at the University of Calabria (Italy). She was appointed Research Fellow at the Catholic University of Louvain (Belgium, 2003), working on the preparation of new hydantoin scaffolds as antibacterial agents. Research Scientist at Sigma- Tau Pharmaceuticals (Italy, 2004), Post-Doctoral Fellow University of Montpellier II, (France, until 2007), she was hired as Assistant Professor in 2008. Associate Professor of Organic and Green Chemistry since 2013, at the University of Montpellier, France, her main research activities concern the development of eco-friendly methodologies for the preparation of biomolecules, heterocyclic compounds and hybrid materials by mechanochemistry, with a main focus on Active Pharmaceutical Ingredients (medicinal mechanochemistry). She also investigates sustainable approaches to homogeneous or heterogeneous metal-catalysed processes by combining enabling technologies with non-conventional media. She is also promoter of sustainability in Higher Education by integrating green chemistry at undergraduate level in organic chemistry courses, teaching laboratories and across the sub-disciplines of chemistry, with a special focus on the fundamentals and the practice of mechanochemistry. She is member of the Advisory Board of the Green Chemistry Commitment (GCC, and the International Mechanochemical Association (IMA, She leads the European Programme COST Action CA18112 (MechSustInd, 2019-2023) – ‘Mechanochemistry for Sustainable Industry ( and and the EU Horizon Project IMPACTIVE (Innovative Mechanochemical Processes to synthesise green ACTIVE pharmaceutical ingredients, 2022-2026).

Felipe García is originally from the coastal town of Gijón (Spain) and gained both his B.Sc. and M.Sc. degrees in Chemistry at the local Oviedo University. In 2001, he moved to the University of Cambridge to carry out his graduate studies on main group imides and phosphides as a Cambridge European Trust and Newton Trust Scholar under the supervision of Prof. Dominic Wright. He then gained a Junior Research Fellowship at Wolfson College (2005) and was appointed College Lecturer in Inorganic Chemistry at Newnham and Trinity Colleges (2006) In March 2011, he moved to Nanyang Technological University as an Assistant Professor. where he developed different aspects of main group chemistry. In 2022, he moved back to his alma mater (i.e., University of Oviedo) as a Margarita Salas Senior researcher (funded by FiCYT). The Margarita Salas Senior programme is a new scheme from the Foundation for the Promotion in Asturias of Applied Scientific Research and Technology (FICYT) to attract highly qualified well-established researchers to R&D and Higher Education institutions in the Principality of Asturias (Spain). Felipe has published over 90 papers on Main Group Chemistry and maintains a strong interest in synthesis of novel compounds for industrial and biological application.