1st Edition

Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing

Edited By Evelina Colacino, Felipe Garcia Copyright 2023
    336 Pages 44 Color & 147 B/W Illustrations
    by CRC Press

    336 Pages 44 Color & 147 B/W Illustrations
    by CRC Press

    This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented.The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large-scale mechanochemistry can meet industrial demands, especially in the pharmaceutical industry.


    • Mechanochemistry is rapidly developing as a multidisciplinary science on the borderline between chemistry, materials science and environmental science
    • This unique text focuses on mechanochemistry with the ability to scale up and illustrates how mechanochemical synthesis is no longer an obstacle
    • This timely book highlights recent advancements describing what can be achieved in chemical synthesis
    • Mechanochemistry enables the synthesis of multiple polymorphic crystalline forms in the production of drugs in the form of tablets or granules in capsules


    Sepelak Vladimir


    Felipe Garcia and Evelina Colacino

    Mechanochemistry – A general introduction : Mechanochemical Based Technologies

    1. In situ monitoring of mechanochemical ball-milling reactions
    2. Ivan Halasz, Stipe Lukin and Tomislav Friscic

    3. The thermodynamics and kinetics of mechanochemical reactions: a computational approach
    4. Bruna S Pladevall and Feliu Maseras

    5. The Thermodymanics and Kinetics of Mechanochemical Reactions: An experimental Approach
    6. Adam A.L.  Michalchuk

    7. Life cycle assessment: a tool for sustainability evaluation of emerging mechanochemical process engineering
    8. Sabrina Spatari, Or Galant and Charles E. Diesendruk

    9. Relevance of the IP strategy for the implmentation of sustainable manufacturing by mechanochemistry
    10. Tanja Bendele

      Solvent-free Sustainable Technologies at large scale

    11. Mechanochemistry and industry: process intensification and beyond
    12. Valerio Isoni

    13. On the theory and recent developments in "batch mechanochemical synthesis – scale-up"
    14. Steffen Reichle and Michael Fellderhoff

    15. Acoustic synthesis (solvent-free) and Resonant Acoustic Mixing (RAM)
    16. Maria Elena Rivas

      Case studies/perspective

    17. Sustainable large scale manufacturing of fine chemicals, active pharmaceutical ingredients and biologically active compounds by non-traditional activation methods and biocatalysis
    18. Manisha Mishra and Bela Torok

    19. Eccentric vibration milling for mechancochemical synthesis: a straightforward route to advanced materials 
    20. Peter Balaz, Macela Achimovicova, Erika Dutkova and Matej Balaz

    21. Scalable solutions for continuous manufacturing by mechanochemical-assisted synthesis
    22. Jamie A. Leitch, Matthew T.J. Williams, and Duncan Browne

      Reduced Solvent Sustainable Technologies

    23. Large-Scale Flow Chemistry
    24. Nicole Neyt, Jaimee Jugmohan, Wessel Bonnet, Jenny-Lee Panayides and Darren Riley

    25. Sustainable synthesis of API in water in industrial setting

      Ning Ye and Fabrice Gallou



    Evelina Colacino received her double Ph.D. (with European Label) in 2002 at the University of Montpellier II (France), and at the University of Calabria (Italy). She was appointed Research Fellow at the Catholic University of Louvain (Belgium, 2003), working on the preparation of new hydantoin scaffolds as antibacterial agents. Research Scientist at Sigma- Tau Pharmaceuticals (Italy, 2004), Post-Doctoral Fellow University of Montpellier II, (France, until 2007), she was hired as Assistant Professor in 2008. Associate Professor of Organic and Green Chemistry since 2013, at the University of Montpellier, France, her main research activities concern the development of eco-friendly methodologies for the preparation of biomolecules, heterocyclic compounds and hybrid materials by mechanochemistry, with a main focus on Active Pharmaceutical Ingredients (medicinal mechanochemistry). She also investigates sustainable approaches to homogeneous or heterogeneous metal-catalysed processes by combining enabling technologies with non-conventional media. She is also promoter of sustainability in Higher Education by integrating green chemistry at undergraduate level in organic chemistry courses, teaching laboratories and across the sub-disciplines of chemistry, with a special focus on the fundamentals and the practice of mechanochemistry. She is member of the Advisory Board of the Green Chemistry Commitment (GCC, www.beyondbenign.org) and the International Mechanochemical Association (IMA, http://imamechanochemical.com). She leads the European Programme COST Action CA18112 (MechSustInd, 2019-2023) – ‘Mechanochemistry for Sustainable Industry (www.mechsustind.eu and https://www.cost.eu) and the EU Horizon Project IMPACTIVE (Innovative Mechanochemical Processes to synthesise green ACTIVE pharmaceutical ingredients, 2022-2026).

    Felipe García is originally from the coastal town of Gijon (Spain) and gained both his B.Sc. and M.Sc. degrees in Chemistry at the local Oviedo University (Spain). In 2001, he moved to the University of Cambridge (UK) to carry out his graduate studies on main group imides and phosphides as a Cambridge European Trust and Newton Trust Scholar under the supervision of Prof. Dominic Wright. He then gained Junior Research Fellowship at Wolfson College (UK, 2005) and was appointed College Lecturer in Inorganic Chemistry at Newnham and Trinity Colleges (UK, 2006). In March 2011, he moved to Nanyang Technological University (Singapore) as Assistant Professor, where he developed different aspects of main group chemistry. In 2022, he moved back to his alma mater (i.e., University of Oviedo) as a Margarita Salas Senior researcher (funded by FICYT). The Margarita Salas Senior programme is a new scheme from the Foundation for the Promotion in Asturias of Applied Scientific Research and Technology (FICYT) to attract highly qualified well-established researchers to R&D and higher education institutions in the Principality of Asturias (Spain). In late 2023, he will move to Monash University in Australia continue his research career. Felipe has published over 90 papers on Main Group Chemistry and maintains a strong interest in the synthesis of novel compounds for industrial and biological applications.

    Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing by Colacino, Garcia and coworkers is a great read for chemists of all levels that discusses not only what technologies we should be investigating as scientists but where they can be best implemented. The text discusses a varying amount of technologies while showing great examples of complexity. The attention to detail on the different areas of scale up, large scale manufacturing, and long lasting impacts of chemical synthesis make this text great for early career researchers to be more aware of where chemistry can make changes while also showing mid/late career chemists how we can be more conscious about our efforts. This will be a great text to use for examples in upper level organic synthesis courses or green chemistry courses that seek to include new technologies.

    - Isaiah R. Speight, Ph.D., Assistant Professor of Chemistry, Department of Chemistry, William & Mary, Williamsburg, VA, USA