This seventh edition of Medical Immunology, now in a full-color presentation, continues to provide a succinct clinical review of the human response to infection while being firmly grounded in science. The authors, distinguished and experienced educators, have been able to anticipate readers’ conceptual challenges and use illustrations, diagrams, and algorithms throughout to simplify complex concepts. With an emphasis on clinical applications, methodological advances, immunological diseases, and innovative interventions, this tried and true guide navigates readers through state-of-the-sciences technologies and demonstrates their implementation in the day-to-day clinical practice of immunology.
Key Features
- Stresses both the basic scientific concepts and clinical correlations to medical practice.
- Progresses logically from normal immune function to abnormalities and clinical diseases.
- Reviews the diagnosis, pathogenesis, and management of autoimmune diseases in a concise, manageable and visual manner
- Continues to be the only current medically-focused immunology text available
- Provides a succinct review of human response to infection with a focus on diagnostic and clinical immunology
Table of Contents
Chapter 1: Introduction
Gabriel Virella
Chapter 2: Leucocytes and Lymphoid Tissues: The Framework of the Immune System
Gabriel Virella
Chapter 3: Major Histocompatibility Complex
Ellen Klohe and Janardan P. Pandey
Chapter 4: The Adaptive Immune Response: Antigens, Lymphocytes and Accessory Cells
Gabriel Virella and John Sleasman
Chapter 5: Immunoglobulins: Structure and Diversity
Gabriel Virella
Chapter 6: Immunoglobulins: Metabolism and Biological Properties
Gabriel Virella
Chapter 7: Genetics of Immunoglobulins: Ontogenic, Biological and Clinical Implications
Janardan P. Pandey
Chapter 8: Antigen-Antibody Reactions
Gabriel Virella
Chapter 9: The Complement System in Health and Disease
Carl Atkinson
Chapter 10: Monocyte and Lymphocyte Membrane Markers: Ontogeny and Clinical Significance
Scott Sugden, Damien Montamat-Sicotte, Karen Yam, Joseph Murphy, Bader Yassine Diab, and Virginia Litwin
Chapter 11: Cell-Mediated Immunity
José C. Crispín And Gabriel Virella
Chapter 12: Adaptive Humoral Immunity and Immunoprophylaxis
Gabriel Virella
Chapter 13: Phagocytic Cells and their Functions
Gabriel Virella And John Sleasman
Chapter 14: Anti-Infectious Innate and Adaptive Immune Responses
Carl Atkinson and Gabriel Virella
Chapter 15: Diagnostic Applications of Immunology
Ajay Grover, Virginia M. Litwin and Gabriel Virella
Chapter 16: Tolerance and Autoimmunity
George C. Tsokos and Gabriel Virella
Chapter 17: Organ-Specific Autoimmune Diseases
G. Virella and George C. Tsokos
Chapter 18: Systemic Lupus Erythematosus
George C. Tsokos
Chapter 19: Rheumatoid Arthritis
George C. Tsokos and Gabriel Virella
Chapter 20: Overview of Hypersensitivity
Gabriel Virella
Chapter 21: IgE-mediated (Immediate) Hypersensitivity
Albert F. Finn, Jr. and Gabriel Virella
Chapter 22: Immunohematology
Armand Glassman and Gabriel Virella
Chapter 23: The Pathogenic Role of Antigen-Antibody Complexes
Gabriel Virella and George C. Tsokos
Chapter 24: Immune System Modulators
Richard Silver and Stephen Elmore
Chapter 25: Transplantation Immunology
Satish N. Nadig and Jane C. Kilkenny
Chapter 26: Tumor Immunology
Juan Carlos Varela
Chapter 27: Lymphocyte and Plasma Cell malignancies
Juan Varela and Gabriel Virella
Chapter 28: Diagnosis of Immune Deficiency Diseases
John W. Sleasman and Gabriel Virella
Chapter 29: Primary Immunodeficiency Diseases
John Sleasman and Gabriel Virella
Chapter 30: AIDS and other Acquired Immunodeficiencies
John Sleasman and Gabriel Virella
Biography
Gabriel Virella obtained his MD and PhD degrees at the University of Lisbon, Portugal, in 1967 and 1974. He did post-doctoral studies in Immunology at the Department of Experimental Pathology, University of Birmingham, England (1968-69) and at the National Institute for Medical Research, Mill Hill, London, England (1969-1970). From 1970 to 1975 was a Researcher at the Gulbenkian Institute of Science, Oeiras, Portugal. He moved to the Medical University of South Carolina (MUSC) in 1975, where he is an Emeritus Professor of Immunology and Microbiology. He has published 260 articles in topics related primarily to immunology, with particular emphasis on the involvement of autoimmune phenomena in the pathogenesis of atherosclerosis. He has described original techniques for the isolation and characterization of antigen-antibody complexes, immunoassays for tetanus and diphtheria antibodies, and for the assay of modified LDL and corresponding antibodies. In 1989 he was co-recipient with Drs. Christoph Gisinger and Maria F. Lopes Virella of the Squibb Award of the Austrian Society for Internal Medicine for the work entitled "Metabolic effects of Lipoprotein Immune Complexes in Macrophages". He co-edited a first edition of "Introduction to Medical Immunology" in 1986, and became the single editor of the 3rd edition, in 1993. The 4 ed. (1999) was translated to the Italian. He has now edited the 7th Ed. of Medical Immunology. In addition, he published "NMS Microbiology and Infectious Diseases", 3rd Ed, Williams&Wilkins, 1997; and NMS Q&A Microbiology, Immunology, and Infectious Diseases, Lippincott Williams & Wilkins, 1999. He was Section Editor of Clinical Immunology from 1989 to 2003. During his tenure at the Medical University of South Carolina he received numerous teaching awards from the students, the Health Science Foundation Teaching Excellence Award, MUSC in 1996 and 2006, Governor's Distinguished Professor Award in 1996 and 2006, the National Robert J. Glaser Distinguished Teacher Award in 2003, and cited as Cited as "Master Teacher" by the Board of Trustees of The Medical University of S.C. in 2007.