7th Edition

Medical Immunology, 7th Edition

Edited By Gabriel Virella Copyright 2020
    480 Pages 148 Color & 11 B/W Illustrations
    by CRC Press

    478 Pages 148 Color & 11 B/W Illustrations
    by CRC Press

    478 Pages 148 Color & 11 B/W Illustrations
    by CRC Press

    This seventh edition of Medical Immunology, now in a full-color presentation, continues to provide a succinct clinical review of the human response to infection while being firmly grounded in science. The authors, distinguished and experienced educators, have been able to anticipate readers’ conceptual challenges and use illustrations, diagrams, and algorithms throughout to simplify complex concepts. With an emphasis on clinical applications, methodological advances, immunological diseases, and innovative interventions, this tried and true guide navigates readers through state-of-the-sciences technologies and demonstrates their implementation in the day-to-day clinical practice of immunology.

    Key Features

    • Stresses both the basic scientific concepts and clinical correlations to medical practice.

    • Progresses logically from normal immune function to abnormalities and clinical diseases.

    • Reviews the diagnosis, pathogenesis, and management of autoimmune diseases in a concise, manageable and visual manner

    • Continues to be the only current medically-focused immunology text available

    • Provides a succinct review of human response to infection with a focus on diagnostic and clinical immunology

    Table of Contents

    Chapter 1: Introduction

    Gabriel Virella

    Chapter 2: Leucocytes and Lymphoid Tissues: The Framework of the Immune System

    Gabriel Virella

    Chapter 3: Major Histocompatibility Complex

    Ellen Klohe and Janardan P. Pandey

    Chapter 4: The Adaptive Immune Response: Antigens, Lymphocytes and Accessory Cells

    Gabriel Virella and John Sleasman

    Chapter 5: Immunoglobulins: Structure and Diversity

    Gabriel Virella

    Chapter 6: Immunoglobulins: Metabolism and Biological Properties

    Gabriel Virella

    Chapter 7: Genetics of Immunoglobulins: Ontogenic, Biological and Clinical Implications

    Janardan P. Pandey

    Chapter 8: Antigen-Antibody Reactions

    Gabriel Virella

    Chapter 9: The Complement System in Health and Disease

    Carl Atkinson

    Chapter 10: Monocyte and Lymphocyte Membrane Markers: Ontogeny and Clinical Significance

    Scott Sugden, Damien Montamat-Sicotte, Karen Yam, Joseph Murphy, Bader Yassine Diab, and Virginia Litwin

    Chapter 11: Cell-Mediated Immunity

    José C. Crispín And Gabriel Virella

    Chapter 12: Adaptive Humoral Immunity and Immunoprophylaxis

    Gabriel Virella

    Chapter 13: Phagocytic Cells and their Functions

    Gabriel Virella And John Sleasman

    Chapter 14: Anti-Infectious Innate and Adaptive Immune Responses

    Carl Atkinson and Gabriel Virella

    Chapter 15: Diagnostic Applications of Immunology

    Ajay Grover, Virginia M. Litwin and Gabriel Virella

    Chapter 16: Tolerance and Autoimmunity

    George C. Tsokos and Gabriel Virella

    Chapter 17: Organ-Specific Autoimmune Diseases

    G. Virella and George C. Tsokos

    Chapter 18: Systemic Lupus Erythematosus

    George C. Tsokos

    Chapter 19: Rheumatoid Arthritis

    George C. Tsokos and Gabriel Virella

    Chapter 20: Overview of Hypersensitivity

    Gabriel Virella

    Chapter 21: IgE-mediated (Immediate) Hypersensitivity

    Albert F. Finn, Jr. and Gabriel Virella

    Chapter 22: Immunohematology

    Armand Glassman and Gabriel Virella

    Chapter 23: The Pathogenic Role of Antigen-Antibody Complexes

    Gabriel Virella and George C. Tsokos

    Chapter 24: Immune System Modulators

    Richard Silver and Stephen Elmore

    Chapter 25: Transplantation Immunology

    Satish N. Nadig and Jane C. Kilkenny

    Chapter 26: Tumor Immunology

    Juan Carlos Varela

    Chapter 27: Lymphocyte and Plasma Cell malignancies

    Juan Varela and Gabriel Virella

    Chapter 28: Diagnosis of Immune Deficiency Diseases

    John W. Sleasman and Gabriel Virella

    Chapter 29: Primary Immunodeficiency Diseases

    John Sleasman and Gabriel Virella

    Chapter 30: AIDS and other Acquired Immunodeficiencies

    John Sleasman and Gabriel Virella


    Gabriel Virella obtained his MD and PhD degrees at the University of Lisbon, Portugal, in 1967 and 1974. He did post-doctoral studies in Immunology at the Department of Experimental Pathology, University of Birmingham, England (1968-69) and at the National Institute for Medical Research, Mill Hill, London, England (1969-1970). From 1970 to 1975 was a Researcher at the Gulbenkian Institute of Science, Oeiras, Portugal. He moved to the Medical University of South Carolina (MUSC) in 1975, where he is an Emeritus Professor of Immunology and Microbiology. He has published 260 articles in topics related primarily to immunology, with particular emphasis on the involvement of autoimmune phenomena in the pathogenesis of atherosclerosis. He has described original techniques for the isolation and characterization of antigen-antibody complexes, immunoassays for tetanus and diphtheria antibodies, and for the assay of modified LDL and corresponding antibodies. In 1989 he was co-recipient with Drs. Christoph Gisinger and Maria F. Lopes Virella of the Squibb Award of the Austrian Society for Internal Medicine for the work entitled "Metabolic effects of Lipoprotein Immune Complexes in Macrophages". He co-edited a first edition of "Introduction to Medical Immunology" in 1986, and became the single editor of the 3rd edition, in 1993. The 4 ed. (1999) was translated to the Italian. He has now edited the 7th Ed. of Medical Immunology. In addition, he published "NMS Microbiology and Infectious Diseases", 3rd Ed, Williams&Wilkins, 1997; and NMS Q&A Microbiology, Immunology, and Infectious Diseases, Lippincott Williams & Wilkins, 1999. He was Section Editor of Clinical Immunology from 1989 to 2003. During his tenure at the Medical University of South Carolina he received numerous teaching awards from the students, the Health Science Foundation Teaching Excellence Award, MUSC in 1996 and 2006, Governor's Distinguished Professor Award in 1996 and 2006, the National  Robert J. Glaser Distinguished Teacher Award in 2003, and cited as Cited as "Master Teacher" by the Board of Trustees of The Medical University of S.C. in 2007.