1st Edition

Medical Nanotechnology and Nanomedicine

By H.F. Tibbals Copyright 2011
    528 Pages 28 B/W Illustrations
    by CRC Press

    528 Pages
    by CRC Press

    Considering the fluid nature of nano breakthroughs—and the delicate balance between benefits and consequences as they apply to medicine—readers at all levels require a practical, understandable base of information about these developments to take greatest advantage of them. Medical Nanotechnology and Nanomedicine meets that need by introducing non-experts to nanomedicine and its evolving organizational infrastructure.

    This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects—an ideal foundation upon which to plan and make decisions.

    Covers the use of nanotechnology in medical applications including imaging, diagnosis and monitoring, drug delivery systems, surgery, tissue regeneration, and prosthetics

    Part of the Perspectives in Nanotechnology series—which contains broader coverage of the societal implications of nanotechnology—this book can be used as a standalone reference. Organized by historical perspective, current status, and future prospects, this powerful book:

    • Explores background, definitions and terms, and recent trends and forces in nanomedicine
    • Surveys the landscape of nanomedicine in government, academia, and the private sector
    • Reviews projected future directions, capabilities, sustainability, and equity of nanomedicine, and choices to be made regarding its use
    • Includes graphical illustrations, references, and keywords to reinforce concepts and aid further research

    In its assessment of alternative and sometimes conflicting concepts proposed for the application of nanotechnology to medicine, this book surveys major initiatives and the work of leading labs and innovators. It uses informative examples and case summaries to illustrate proven accomplishments and imagined possibilities in research and development.

    Part I: Perspectives

    Nanomedicine: Scientific Basis and Societal Implications



    What Is Nanoscience and Where Does It Fit in the Sciences?

    Origins of Nanotechnology

    Molecular and Cell Biology and Protein Bioscience: A Model of Life as Organic Nanomachinery

    Nanotechnology Leads to a Fundamentally New Approach to Engineering Design

    Societal and Economic Impacts

    Impact of Nanotechnology on Medicine

    The Grand Challenge of Nanotechnology

    Some Definitions and Nanomedical Areas of Emphasis

    Healthcare Crisis: How Can Nanotechnology Contribute to a Solution?

    Historical Perspectives and Technological Breakthroughs

    Brief Highlights of Nanomedicine History

    Medical Milestones

    Emerging National and Global Nanomedicine Initiatives

    Some Developments in Nanomedicine

    Current Examples of Nanomedicine in Practice and Research

    NIH Nanomedicine Initiative

    Putting Medical Nanoscience into Practice: Medical Nanotechnology and Nanomedicine


    Part II: Beginnings of Medical Nanotechnology

    Nanomedicine: Proposals and Promise

    Introduction and Overview

    Impacts of Nanotechnology on Medicine

    An Overview of the Architecture of Medical Nanotechnology and Nanomedicine

    Nanoscience: Bridging the Gap between Biochemistry and Cell Biology

    Medication: Nanoparticles for Imaging and Drug Delivery

    Introduction: The Emergence of Nanotechnology Applications in Medicine

    Nanoparticles for Medical Imaging

    Nanoparticles for Targeted Imaging and Delivery of Energy

    Nanoparticles for Delivery of Drugs

    Some Therapeutic Application Areas for Nanoparticles Theranostics

    Conclusion: Nanomedicines Have a Broad Impact Throughout Medicine

    Intervention: Nanotechnology in Reconstructive Intervention and Surgery

    Nanoengineered Materials in Surgical and Restorative Applications

    Bridging the Gap between Drugs and Surgery with Endoscopic MEMS

    Robotics in Surgery: The Technology

    Robotics in Surgical Practice

    Recent Advances and Emerging Technologies in Surgical and Endoscopic Navigation

    Summary of Translational Development of Nanoengineered Regenerative Tissue Therapy

    Regeneration: Nanomaterials for Tissue Regeneration

    Introduction: The Role of Nanotechnology in Tissue Regeneration

    Biomaterials for Tissue Regeneration

    Nanotechnology and Tissue Engineering

    Tissue Engineering for Nerve Regeneration

    Nanotechnology for Regeneration of the Brain

    Use of Nanoengineered Scaffolding with Cells for Central Nervous System Regeneration

    New Developments in Cell Therapy Accelerated by Nanoscience and Nanotechnology

    Conclusion: Toward Clinical Therapies Based on Integrated Medical Nanoscience

    Restoration: Nanotechnology in Tissue Replacement and Prosthetics

    Nanoscale Biomaterials and Technologies for Tissue Engineering

    Application of Tissue Engineering in Medicine

    Nanotechnology and Prosthetics

    Summary of Nanoengineered Restorative Tissue Engineering and Prosthetics

    Diagnosis: Nanosensors in Diagnosis and Medical Monitoring

    Sensors: Nanotechnology-Driven Advances in Diagnostic and Monitoring Technology

    Technologies for Genomics and Proteomics

    Applied Genomics and Proteomics: From Personalized Medicine to Global Epidemiology

    Real-Time and In Vivo Medical Monitoring


    Part III: Future Directions and Transformations

    Thesis, Antithesis, Synthesis: Integrated Biomolecular Nanoscience

    Maturation of Medical Nanotechnologies

    Continued Impacts of Nanotechnology—Driven Capabilities

    Nanotechnologies in Translation from Research

    Indirect Impacts of Nanotechnology-Enabled Systems on Practice

    Translation of Medical Nanotechnologies into Clinical Practice

    Challenging Boundaries: Life and Material, Self and Environment

    Nanotechnology and Medicine: A Powerful Confluence

    Historical Origins of Medical Traditions

    Knowledge of the Genome

    Replacement Parts for the Body

    Augmentation of Human Characteristics and Abilities

    Extension of Life

    Issues with Transplanted Cells for Regeneration

    Medicalization of Normal Conditions

    Other Boundaries Yet More Weird

    Sustainability and Future Choices for Societies

    Nanotechnology and Medicine as a Socioeconomic Activity

    Questions of Change



    Tibbals, Harry F.

    "Given that nanomedicine involves the application of fields as diverse as quantum physics, materials science, organic chemistry, molecular biology, semiconductor electronics, microfabrication, and mathematics, one might imagine that finding a good introductory presentation on this topic would be impossible. Fortunately, Tibbals’ book is up to the challenge. ... As befits an introductory book, the presentation is more comprehensive than deep and should be readily accessible to both the patient physician and the intelligent layman. ... However, each chapter contains a particularly rich selection of references for those readers interested in pursuing a particular topic in detail. ... In conclusion, this book provides a well-written, very well-referenced, modestly illustrated, and clinically focused evaluation of the current state of nanomedicine and its future prospects. Highly recommended."
    --D. John Doyle, MD, Ph.D, Department of Anaesthesiology, Cleveland Clinic, Ohio, USA, Anesthesia & Analgesia, November 2013