Assembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily practice.
- synthesizes the scientific principles, clinical trial results, and clinical implications of emerging and translational melanoma therapies
- covers the entire range of translational research and therapies, including pathogenesis, progression pathways, immunotherapy, gene therapy, adjuvant therapy, surgical staging, and metastatic disease
- provides context and perspective to enable the clinician to select and use new therapies effectively and knowledgeably
1. UV radiation in melanoma development and pathogenesis. 2. Overview of molecular pathways in melanoma. 3. CHALLENGING MELANOCYTIC NEOPLASMS:
SPITZOID MELANOMA VERSUS SPITZ NEVUS. 4. Melanoma genomics: Techniques and implications for therapy. 5. Ras signaling in melanoma development and prevention. 6. Targeting BRAF activity as a novel paradigm for melanoma therapy. 7. Therapeutic targeting of the melanoma stem cell population. 8. Pigmentation pathways and Microphtalmia-Associated Transcription Factor as new targets in melanoma. 9. Understanding interferon: Translating biologic advances into clinical progress. 10. Interferon and autoimmunity. 11. New approaches for optimizing melanoma vaccines. 12. Adoptive T cell immunotherapy. 13. Procurement of human melanoma specimens for translational research: Practical and legal considerations. Glossary of clinical and scientific terms.