1st Edition

Melatonin Therapeutic Value and Neuroprotection

    576 Pages
    by CRC Press

    574 Pages
    by CRC Press

    There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include:

    • The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism

    • The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer

    • Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms

    • The cardioprotective role of melatonin

    • The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases

    • Use as a therapeutic agent for treating epilepsy and degenerative discs

    • Treatment for obesity, diabetes mellitus, and other metabolic disorders

    • Protective role in peri-natal hypoxic-ischemia

    The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.

    Melatonin Production and Bioavailability. Deviations of Melatonin Levels and Signaling in Aging and Diseases: Options and Limits of Treatment. Pineal Gland Volume and Melatonin. Melatonin’s Beneficial Effects in Metabolic Syndrome with Therapeutic Applications. Therapeutic Applications of Melatonin in Pediatrics. Neuroprotective Effect of Melatonin on Perinatal Hypoxia–Ischemia. Melatonin as a Therapeutic Agent for Sepsis. Melatonin’s Cardioprotective Role. Melatonin: Therapeutic Value and Neuroprotection in Stroke. Melatonin’s Antiapoptotic Activity in Neurodegenerative Diseases. MT2 Melatonin Receptors: Their Role in Sleep and Neuropsychiatric Disorders. Melatonin: Its Hepatoprotective Actions and the Role of Melatonin Receptors. Melatonin Signaling in the Control of Development and Replication. Melatonin: Regulator of Adult Hippocampal Neurogenesis. Comparison of Neuroprotective Effect of Melatonin in the Nigrostriatal and Mesolimbic Dopaminergic Systems of the Zitter Rat. Melatonin’s Neuroprotective Role in Parkinson’s Disease. Neuroprotective Role of Melatonin in Glaucoma. Melatonin Receptors and Their Preventive Role in Carcinogenesis. Enhancement of Antitumor Activity of Ursolic Acid by Melatonin in Colon Cancer Cells. Synthetic Melatonin Receptor Ligands. Evaluation of Synthetic Melatonin Analog Antioxidant Compounds. Melatonin’s Analogues in Glaucoma. Melatonergic Drugs as Therapeutic Agents for Insomnia and Depressive Disorders. Agomelatine: A Neuroprotective Agent with Clinical Utility beyond Depression and Anxiety. Melatonergic Antidepressant Agomelatine in Depressive and Anxiety Disorders. Effects of Melatonin and Melatonergic Drugs in Transgenic Mouse Models of Alzheimer’s Disease. Melatonin’s Mitochondrial Protective Role in Alzheimer’s Mice: Role of Melatonin Receptors. Melatonin and Its Therapeutic Implications in Injuries of the Developing Brain and Retina. Melatonin’s Protection against Human Prion-Mediated Neurotoxicity. Melatonin’s Protection


    Professor Venkataramanujam Srinivasan, PhD, MAMS, started his professional career as an assistant professor at the Institute of Physiology, Madurai Medical College, Madurai, Tamil Nadu, India, where he served for 24 years. Along with teaching physiology to undergraduate medical students, he undertook various collaborative research studies with the Department of Psychiatry and published a number of papers on lithium, catecholamine metabolism, the pineal gland, and melatonin both in national and international medical and life sciences journals. He has also served as one of the advisory council members for the International Society of Psychoneuroendocrinology (ISPNE) for ten years. Professor Srinivasan then undertook teaching assignments as associate professor of physiology at the University Sains Malaysia (USM). He has collaborated on research publications with a number of professors and research scientists working in different universities internationally. Since May 2009, he has undertaken research studies on melatonin and melatonergic drugs from Sri Sathya Sai Medical Educational and Research Foundation, an international medical sciences research study center in Kovai Thirunagar, Tamil Nadu, India and has published number of papers in indexed medical journals. He also edited a book on melatonin and melatonergic drugs in clinical practice, published by Springer in February 2014.

    Dr. Gabriella Gobbi is an associate professor in the Department of Psychiatry, McGill University and a staff psychiatrist at the McGill University Health Center (MUHC), Montreal, Canada. Her research interests include understanding the pathophysiology of major depression and related disorders and discovering new treatments for them. In particular, her laboratory conducts research on the short- and long-term effects of cannabis use in mood and anxiety and the potential beneficial effects of drugs acting on the endocannabinoid system (endogenous cannabis) to cure mental dise