This book presents an authoritative review of the research regarding the influences of anabolic-androgenic steroids on metabolism. The book provides a concise description of the biochemistry of these steroids using simple terms and includes methods of separation and their clinical applications. The first section of the book examines the general structure, nomenclature, and classification of anabolic-androgenic steroids. Subsequent chapters explore concepts basic to understanding the pathways of their metabolism in both target and non-target tissues, including the interactions of steroids with receptors and the effects of steroids on the cellular metabolism of skeletal muscle. The changes and molecular base of modifications in metabolism during exercise involving anabolic-androgenic steroids are also described. Finally, a comprehensive review of methods for scanning and identifying anabolic-androgenic steroids in biological fluids is presented, as well as a discussion regarding the applicability and limitations of these techniques. The book provides valuable reference information for all scientists and clinicians engaged in sports medicine, exercise biochemistry, and endocrinology.
Anabolic-Androgenic Steroids (AAS): Structure, Nomenclature, Classification, and AAS Biological Properties. Extracellular Androgen Binding Proteins. AAS Intracellular Reception. Translocation of Cytoplasmic Hormone-Receptor Complexes to Cellular Nucleus. Molecular Mechanisms of AAS Action. Enzymic Systems Participating in AAS Metabolism. Role of AAS in Metabolism Regulation in Norm and Pathology and use in Medicine and Cattle Breeding. AAS Radioimmunoassay. Chromatographic Methods of AAS Determination. References. Conclusion. Index.