This book shows how the biological transport, bioaccumulation, disposition, and toxicity of polycyclic aromatic hydrocarbons (PAH) in the aquatic environment are influenced by the ability or inability of organisms to metabolize these environmental pollutants. Written by leading scientists in the fields of PAH metabolism and toxicity in both aquatic and mammalian systems, this book discusses recent advances in the areas of PAH biogeochemistry and bioaccumulation, microbial degradation, enzymes of activation, and detoxication, metabolism of PAH, and laboratory and field studies on carcinogenic/toxic effects. Additionally, important similarities and differences in metabolism of PAH by aquatic and terrestrial organisms are featured. The discussion of bioavailability, metabolism, and subsequent toxic effects should aid in the assessment of the ecological consequences of PAH in the aquatic environment.
Table of Contents
Bioavailability of Polycyclic Aromatic Hydrocarbons in the Aquatic Environment. Microbial Degradation of Polycyclic Aromatic Hydrocarbons (PAH) in the Aquatic Environment. Biotransformation and Disposition of Aromatic Hydrocarbons (PAH) in Aquatic Invertebrates. Biotransformation and Disposition of Polycyclic Aromatic Hydrocarbons (PAH) in Fish. Enzymes involved in Metabolism of PAH by Fishes and Other Aquatic Animals: Oxidative Enzymes (or Phase I Enzymes). Enzymes involved in Metabolism of PAH by Fishes and Other Aquatic Animals: Hydrolysis and Conjugation Enzymes (or Phase II Enzymes). Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Subcellular Fractions and Cell Cultures from Aquatic and Terrestrial Species. Factors Influencing Experimental Carcinogenesis in Laboratory Fish Models. PAH, Metabolites, and Neoplasia in Feral Fish Population. Hydrocarbons in Marine Mollusks: Biological Effects and Ecological Consequences. Index.