Metabolomics: Practical Guide to Design and Analysis, 1st Edition (Hardback) book cover

Metabolomics

Practical Guide to Design and Analysis, 1st Edition

Edited by Ron Wehrens, Reza Salek

Chapman and Hall/CRC

276 pages | 55 Color Illus. | 11 B/W Illus.

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Description

Metabolomics is the scientific study of the chemical processes in a living system, environment and nutrition. It is a relatively new omics science, but the potential applications are wide, including medicine, personalized medicine and intervention studies, food and nutrition, plants, agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field, from masters to postgraduate students, PhDs, postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies, but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather, the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples, computing and exercises.

Key Features:

  • Provides an overview of qualitative /quantitative methods in metabolomics
  • Offers an introduction to the key concepts of metabolomics, including experimental design and technology
  • Covers data handling, processing, analysis, data standards and sharing
  • Contains lots of examples to illustrate the topics
  • Includes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences

Table of Contents

Preface

Overview of Metabolomics - Oscar Yanes, Reza Salek, Igor Marin, Marta Cascante

Study Design and Preparation - Pietro Franceschi, Oscar Yanes and Ron Wehrens

Measurement Technologies - Oscar Yanes, Katherine Hollywood, Roland Mumm, Maria Vinaixa, Naomi Rankin, Ron Wehrens and Reza Salek

Mass Spectrometry Data Processing - Steffen Neumann, Oscar Yanes, Roland Mumm, Pietro Franceschi

Nuclear Magnetic Resonance Spectroscopy Data Processing - Maria Vinaixa, Naomi Rankin, Jeremy Everett and Reza Salek

Statistics: the essentials - Ron Wehrens and Pietro Franceschi

Data fusion in metabolomics - Johan A. Westerhuis, Frans van der Kloet, Age K. Smilde

Genome-scale metabolic networks - Clément Frainay & Fabien Jourdan

Metabolic flux - Igor Marín de Mas and Marta Cascante

Data Sharing and Standards

Conclusion

Appendix: Metabolic and transcriptional response of Arabidopsis thaliana wildtype and mutants to Phytophthora infestans - Tilo Lübken, Michaela Kopischke, Kathrin Geissler, Lore Westphal, Dierk Scheel, Steffen Neumann, Sabine Rosahl

About the Editors

Ron Wehrens was an associate professor at the Radboud University Nijmegen (Netherlands) before founding the Biostatistics unit at the Fondazione Edmund Mach, San Michele all’Adige (Italy). Currently, he is Business Unit Manager at Biometris, Wageningen University & Research, Netherlands.

Reza Salek* has worked in the past in the University of Cambridge and The European Molecular Biology Laboratory European Bioinformatics Institute (EMBL EBI), Cambridge UK. He is currently scientist at The International Agency for Research on Cancer, an intergovernmental agency forming part of the World Health Organization of the United Nations, Lyon France.

*Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organization

About the Series

Chapman & Hall/CRC Mathematical and Computational Biology

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Subject Categories

BISAC Subject Codes/Headings:
MAT029000
MATHEMATICS / Probability & Statistics / General
SCI008000
SCIENCE / Life Sciences / Biology / General
SCI010000
SCIENCE / Biotechnology