Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well.
Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include:
Comparative Risk Assessment Associated with Exposure of Human and Nonhuman Biota to Genotoxic Agents and Ionizing Radiation (M.D. Waters, D.M. DeMarini, A. Richard, and M.D. Shelby). Methods for Exposure Assessment to Genotoxic Agents (D.W. Layton, T. McKone, J. Knezovich, and J.J. Wong). Methods for Dose and Effect Assessment (J. Favor, J. Filser, U.H. Ehling, E. Vogel, and A.A. van Zeeland). Risk Characterization Strategies for Genotoxic Agents (J. Lewtas, D.M. DeMarini, J. Favor, D.W. Layton, J.T. MacGregor, J. Ashby, P.H.M. Lohman, R.H. Haynes, and M.L. Mendelsohn). Monitoring Environmental Genotoxicants: A Report of the ICPEMC Working Group on Environmental Monitoring (J. MacGregor, J. Lewtas, G.G. Pesch, R. Jensen, L.D. Claxton, and W.R. Lower).