1st Edition

Methods in Aging Research



ISBN 9780849331121
Published June 29, 1998 by CRC Press
720 Pages 16 B/W Illustrations

USD $205.00

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Book Description

Gerontological research is currently of great interest due to ever-increasing longevity of human life spans. Created to provide researchers and scientists with the technical methods essential to their work, Methods in Aging Research is a practical bench-top guide for everyone who plans, designs, or conducts research in aging. It highlights experimental procedures that are key to the investigation of the biological aging phenomena.
Methods in Aging Research is a state-of-the-art reference that offers the most direct and clear cut descriptions available of methodological procedures used in aging research. Methods and protocols are critically evaluated and the advantages and disadvantages of each technique are explored. More than 70 expert contributors from around the world share their combined knowledge on a broad range of topics essential to everyone involved in cultivating and developing the gerontological research frontier.

Table of Contents

General Theoretical Approaches to Aging Research
Population Study of Mortality and Longevity with Gompertzian Analysis, J.R. Carey
Design of Cross-Sectional, Longitudinal, and Sequential Studies in Gerontology, D. Ingram
Mathematical and Computational Tools for Gerontological Research, T.M. Witten
Experimental In Vitro Models in Aging Research
Use of the Fibroblast Model, V.J. Cristofalo, M. Tresini, C. Volker, and M.K. Francis
Electrophysiological Assessment of Aged
Hippocampus In Vivo and In Vitro, G.M. Rose, K.L. Heman, G.K. Payapali, and D.A. Turner
Using Drosophilia in Experimental Aging Research, R. Arking and R.C. Woodruff
Experimentation with Nematodes, A.Z. Reznick and D. Gershon
Experimentation with Yeast Model, S. Kim, P.A. Kirchman, A. Benguria, and S.M. Jazwinski
Vertebrate Models in Aging Research
Long-Term Housing of Rodents Under Specific Pathogen-Free Barrier Conditions, R.W. Hart, S.M. Lewis, B. Leard, and A. Turturro
Choice of Rodent Model for Aging Research, E.J. Masoro
Aging Experiments Using Non-Human Primates, R. Colman and J.W. Keminitz
Methods of Assessing Aging Processes
Dietary Restriction, H.A. Bertrand, J.T. Herlihy, Y. Ikeno, and B.P. Yu
Study Design for Nutritional Assessments in the Elderly, H. Payette, Y. Guigoz, and B.J. Vellas
Exercise, L.L. Ji and M.T. Gore
Changes in Neurotransmitter Exocytosis: A Target for Regulation During Aging, H.Y. Wang, D.L. Snyder, J. Roberts, and E. Friedman
Pathological Analysis in Aging Research, G.B. Hubbard and Y. Ikeno
Molecular and Evolutionary Probes of Senescence Alterations
Transgenic Manipulation of the Mouse Genome, C.A. Walter
Telomeres and Replicative Senescence, R.C. Allsopp, S.S. Wang, N.W. Kim, and C. B.Harley
Evolutionary Approaches to Probing Aging Mechanisms, S.N. Austad and D.J. Holmes
Apoptosis and Programmed Cell Death, I.D. Bowen
Mitochondrial DNA Deletions, M.N. Gadaleta, A.M.S. Lezza, and P. Cantatore
Techniques for Exploring Age-Related Intra- and Subcellular Changes
Intracellular Signal Transduction Pathways Involved in Hepatocyte DNA Synthesis Following Growth Factor Stimulation, Y. Liu,, N.J. Holbrook, G.C. Kokkonen, S. Kitano, and G.S. Roth
Measurements of Mitochondrial Oxygen Radical Production, G. Barja
Methods for the Study of Immune Cells in Aging, G. Fernandes
Techniques for Assessing Age-Related Oxidative Modification
Techniques for Assessing Age-Related Oxidative Modification, M. Matsuo and T. Kaneko
Measurement of Oxidative DNA Damage Using the Technique of Gas Chromatography-Mass Spectrometry, M. Dizdaroglu
A Transgenic Mouse Model for Studying Mutations In Vivo, J. Vijg, M.E.T. Dolle, and M.E.T.I. Boerrigter
Protein Oxidation, P.E. Starke-Reed
Glycation, Glycoxidation, and Other Maillard Reaction Products, V.M. Monnier, J.F. Fogarty, and D.R. Sell

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