In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents source material, useful advice, and guidance to specific details as well as examples of current usage.
With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental design.
Table of Contents
The Idiosyncratic Problems Associated with Pain Research. Techniques for Assessing Nociception in Murine Subjects. Techniques for Mutagenesis of the Murine Opioid System In Vivo. Animal Models of Pain. Methods in Visceral Pain Research. The Cytokine Challenge: Methods for the Detection of Central Cytokines in Rodent Models of Persistent Pain. Extracellular Sampling Methods. Electrophysiological Recording Techniques in Pain Research. Membrane Properties: Ion Channels. Morphological Techniques; Light and Electron Microscopy, Labeling Methods. Quantitative Morphology in Relation to Long-Term Pain States; Estimates of Neuron Numbers. Non-Invasive Brain Imaging Methods for Assessing Central Pain Mechanisms. Methods for Imaging Human Brain Pathophysiology of Chronic Pain. Induction of Pain in Experimental, Clinical, and Pharmacological Studies.