Methods in Pain Research: 1st Edition (Hardback) book cover

Methods in Pain Research

1st Edition

Edited by Lawrence Kruger

CRC Press

336 pages | 64 B/W Illus.

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Hardback: 9780849300356
pub: 2001-06-22
eBook (VitalSource) : 9780429123986
pub: 2001-06-22
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In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents source material, useful advice, and guidance to specific details as well as examples of current usage.

With each topic presented by one or more of the leading experts in the field, it examines the major modern techniques used in studying pain, including gene linkage, brain imaging methods, the use of transgenic rodent models, painful sensory neuropathy models, and more. The material also covers conventional methods of pain study, such as anatomical and electophysiological techniques. Methods in Pain Research provides up-to-date methodology and a guide to the strategies of experimental design.


"The author's objective is to address methods of pain research from different angles, particularly considering the protocols developed in anesthesia and neuroscience laboratories across the world. Those objectives are clearly met…In a well-written approach, the authors address different points of pain research…The scope is broad but the text, to-the-point. The author's expertise is expressed in the conciseness of the text, the graphic quality, the illustrations, and the explanations for the procedures…This is an important book for neuroscience libraries and laboratories involved in the study of pain. 4 stars!"

- Celso Agner, MSc, MD, Albany Medical Center, New York, USA in Doody's Notes

Table of Contents

The Idiosyncratic Problems Associated with Pain Research, Lawrence Kruger

Assessing Nociception in Murine Subjects, Jeffrey S. Mogil, Sonya G. Wilson, and You Wan

Techniques for Mutagenesis of the Murine Opioid System In Vivo, Michael D. Hayward and

Malcolm Low

Animal Models of Pain, Gary Bennett

Methods in Visceral Pain Research, Timothy J. Ness and Gerald F. Gebhart

The Cytokine Challenge: Methods for the Detection of Central Cytokines in Rodent Models of Persistent Pain, Sarah M. Sweitzer, Janice L. Arruda, and Joyce A. DeLeo

Extracellular Sampling Techniques, Igor Spigelman, Neubert Y. Matsuka, and N.T. Maidment

Electrophysiological Recording Techniques in Pain Research, Igor Spigelman, Michael S. Gold, and Alan R. Light

Membrane Properties: Ion Channels, Michael S. Gold

Anatomical Methods in Pain Research, Susan Carlton and A. Todd

Quantitative Morphology in Relation to Long-Term Pain States: Estimates of Neuron Numbers, Richard E. Coggeshall

Functional Brain Imaging in Humans: Methodology and Issues, Karen Davis

Methods for Imaging Human Brain Pathophysiology of Chronic Pain, Vania A. Apkarian, Ogor D. Grachev, Beth R. Krauss, and Nikolaus M. Szeverenyi

Methods for Induction and Assessment of Pain in Humans with Clinical and Pharmacological Examples, Thomas Graven-Nielson, Marta Segerdahl, Peter Svensson, and Lars Arendt-Nielson

About the Series

Frontiers in Neuroscience

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Subject Categories

BISAC Subject Codes/Headings:
HEALTH & FITNESS / Pain Management
MEDICAL / Research
SCIENCE / Life Sciences / Neuroscience