Behavioral techniques used in animals to model human diseases and predict effects of novel drugs are as varied as the numbers of scientists who use them. Consequently, behavioral analysis is becoming an increasingly indispensable tool for the neuroscientist as information gained at the molecular and cellular level is put into practice in fully behaving animal subjects.
Uses Animal Behavior Models to Examine Effects of Therapeutic Treatments on Human Cognition
With contributions from more than 40 field specialists, Methods of Behavioral Analysis in Neuroscience reflects six years worth of updates to its first bestselling edition and elucidates new behavioral approaches that are quickly becoming field standards. This edition features new material on the relevance of transgenic mouse models for Alzheimer’s disease, behavioral methods for assessing the cognitive impairment associated with major psychotic disorders, the revival of the scopolamine reversal model for assessing the clinical relevance of AD drugs, and approaches to assessing cognitive impairment in aged mice.
Each chapter presents theoretical background, methodology, and data interpretation, and many chapters include real-world examples of experiments that incorporate the models. With step-by-step, easy-to-reproduce methodologies, this sharply focused work covers well-studied behavioral approaches that provide a better understanding of the effects of disease and allow for better predictability of the effects of therapeutic treatments on the human cognition. It takes the guesswork out of designing the methodology for many of the most widely used animal behavioral approaches developed for the study of brain disorders, drug abuse, toxicology, and cognitive drug development.
Table of Contents
Transgenic Mouse Models of Alzheimer’s Disease: Behavioral Testing and Considerations, K.J. Bryan, H. Lee, G. Perry, M.A. Smith, and G. Casadesus
Cued and Contextual Fear Conditioning for Rodents, P. Curzon, N.R. Rustay, and K.E. Browman
Drug Discrimination, R. Young
Conditioned Place Preference, A.J. Prus, J.R. James, and J.A. Rosecrans
Anxiety-Related Behaviors in Mice, K.R. Bailey and J.N. Crawley
Behavioral Assessment of Antidepressant Activity in Rodents, V. Castagne, P. Moser, and R.D. Porsolt
Assessing Attention in Rodents, P.J. Bushnell and B.J. Strupp
The Behavioral Assessment of Sensorimotor Processes in the Mouse: Acoustic Startle, Sensory Gating, Locomotor Activity, Rotarod, and Beam Walking, P. Curzon, M. Zhang, R.J. Radek, and G.B. Fox
Intravenous Drug Self-Administration in Nonhuman Primates, L.L. Howell and W.E. Fantegrossi
Contextually Induced Drug Seeking During Protracted Abstinence in Rats, J.J. Buccafusco and L. Shuster
Operant Analysis of Fronto-striatal Function in Rodents, M.D. Dobrossy, S. Brooks, R. Trueman, P.J. Brasted, and S.B. Dunnett
Working Memory: Delayed Response Tasks in Monkeys, J.S. Rodriguez and M.G. Paule
Spatial Navigation (Water Maze) Tasks, A.V. Terry, Jr.
Water Maze Tasks in Mice: Special Reference to Alzheimer’s Transgenic Mice, D. Morgan
Behavioral Neuroscience of Zebrafish, E.D. Levin and D.T. Cerutti
Caenorhabditis elegans Model for Initial Screening and Mechanistic Evaluation of Potential New Drugs for Aging and Alzheimer’s Disease, Y. Luo, Y. Wu, M. Brown, and C.D. Link
The Revival of Scopolamine Reversal for the Assessment of Cognition-Enhancing Drugs, J.J. Buccafusco