Several micro- and nanomanipulation techniques have emerged in recent decades thanks to advances in micro- and nanofabrication. For instance, the atomic force microscope (AFM) uses a nano-sized tip to image, push, pull, cut, and indent biological material in air, liquid, or vacuum. Using micro- and nanofabrication techniques, scientists can make manipulation tools, such as microgrippers and nanotweezers, on the same length scale as the biological samples.
Micro and Nano Techniques for the Handling of Biological Samples reviews the different techniques available to manipulate and integrate biological materials in a controlled manner, either by sliding them along a surface (2-D manipulation), or by gripping and moving them to a new position (3-D manipulation). The advantages and drawbacks are mentioned together with examples that reflect the state-of-the-art in manipulation techniques for biological samples.
Thanks to the advances in micro- and nanomanipulation techniques, the integration of biomaterials with physical transducers has been possible, giving rise to new and highly sensitive biosensing devices. Although great progress has been made, challenges are still present. To understand the complex interactions between and inside biological samples, scientists will always be working on improving technologies to manipulate, transport, sort, and integrate samples in different environments. Balanced between simplicity for the beginner and hardcore theory for the more advanced readers, this book is the ideal launching point for sharpening the scientific tools required to address these challenges.
"Written as a multi-authored text by pioneers and specialists in their respective research fields, this timely monograph is not only an exhaustive and updated compilation of bibliography related to micro and nano techniques in use for efficient manipulation and integration of biological materials, but also a practical guide for all those interested in their direct application to practical studies. This book is an ideal text for academics, physicians and scientists working in this interesting and promising research area, but is also suitable for newcomers trying to obtain a general but complete overview of the subject."
—Chromatographia, (2013) 76:299–300
Interfacing Biological Material with Micro- and Nanodevices, Jaime Castillo-León and Winnie E. Svendsen
Atomic Force Microscopy for Liquid Applications, Zachary James Davis
Manipulation by Electrical Fields, Maria Dimaki
Optical Manipulation Techniques, Kirstine Berg-Sørensen
Ultrasonic Manipulation Techniques, Stefano Oberti and Jürg Dual
3D Biomanipulation Using Microgrippers, Peter Bøggild
Magnetic Manipulation of Biological Structures, Maria Dimaki and Winnie E. Svendsen
Microfluidic Manipulation of Biological Samples, Fridolin Okkels