This book presents advances in the interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. It discusses interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation.
Table of Contents
Measurement and Interpretation of MiRNA Expression Profiles
MicroRNA Expression Analysis by LNA Enhanced Microarrays
Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs
Massively Parallel MicroRNA Profiling in the Haematologic Malignancies
Who Dunit? MicroRNAs Involved in Prostate Cancer
Creation, Evolution and Regulation
Mirome Architecture and Genomic Instability
Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks
Analysis of MicroRNA Profiling Data with Systems Biology Tools
Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs
Yuriy Gusev, PhD, assistant professor in Bioinformatics, Department of Surgery, at the University of Oklahoma Health Sciences Center, is instrumental in the ongoing development and activities of a surgical research facility focused on molecular and cellular studies of human diseases related to surgery. He is responsible for the management of computerized cell imaging and bioinformatics systems for gene expression micro-arrays technologies in Surgical Research Core Facilities as well as the education of residents, postdoctoral fellows, and medical and graduate students.
"Topics on microRNAs have taken scientists by storm in the last seven years. Today more than 5500 publications related to microRNAs can be found in PubMed. Do we really need another book for readers already saturated with this topic? The answer is a definite yes. Yuriy Gusev has wisely put together a fine book linking various aspects of the study of microRNAs starting with profiling of microRNoma, the functional study of pathway networks involving miRNAs as well as evolutionary models of microRNoma evolution or mathematical models of posttranscriptional regulation of microRNAs. Readers will find the book different compared with others already published. One thing is certain: the curiosity of the readers will increase with every page turned."
—George A. Calin, MD Anderson Cancer Center