1st Edition
Microbial Enzymes as Potential Biotherapeutics in Human Healthcare
Chapter 1: Exploring the Broad-Spectrum Potential of Microbial Therapeutic Enzymes
Swaroop S Kumar, Dileep Francis, Resmi Ravindran and A Sabu
Chapter 2: Therapeutic Applications of Microbial Enzymes: Recent Innovations and Future Prospects
Lakshmi Kesari Ambika
Chapter 3: Advances in the Production and Purification of Microbial Enzymes
Shabeer Ali H., Satish Mishra
Chapter 4: Challenges in Stability, Delivery, and Targeting of Enzyme Therapeutics
Karthi Sreedevi and Sandeep Palakkil Mavilavalappil*
Chapter 5: Microbial Enzyme Therapeutics as Anti-Inflammatory Agents
Sharanya CS, Kathiresan Natarajan
Chapter 6: Enzybiotics: An Emerging Frontier in Antibacterial Therapy
Dileep Francis, Chris Melvina, Christina Rose George, Mónica L. Chávez-González
Chapter 7: Microbial Fibrinolytic Enzymes and their Therapeutic Potential
Swapna Kunhiraman, Sabu Abdulhameed
Chapter 8: Microbial Enzymes in Cancer Therapy: Potential and Progress
Amrutha M, Anaswara P, Lakshmi shaji, K Madhavan Nampoothiri
Chapter 9: Uricases from Microbes- Therapeutic Applications
Nimisha Vijayan P, Sabu Abdulhameed
Chapter 10: Pharmaceutical Applications of Microbial Proteases
Preetha Nair, Telphy Kuriakose and Bannhi Das
Chapter 11: Tannase for the production of therapeutically relevant bioactive compounds
Cristóbal N. Aguilar, José Luis Martínez-Hernández, José Sandoval-Cortes
Chapter 12: Therapeutic applications of Lipases
Gokul M and Indu C Nair
Chapter 13: Microbial Collagenases: Unveiling Therapeutic Horizons and Diverse Applications
Janice Marianne John and Shinomol George Kunnel
Chapter 14: Harnessing Microbial Enzymes as Biosensors for Therapeutic Applications
Harsha Mohan, Febiya Anna Fedin and Jayachandran K
Chapter 15: Microbial Enzymes as Digestive Aids
Athira V. Anand and T. S. Swapna*
Chapter 16: Microbial Enzymes in Wound Healing and Tissue Regeneration
Fathima Rumaisa, Mini S. and Priya Josson Akkara
Chapter 17: The Role of Regulatory Authorities And Ipr in The Commercialization of Therapeutic Microbial Enzymes
Vani Kesari A., Akhila Ajayakumar, Riswana V. P.
Biography
Dr. Dileep Francis is currently an Assistant Professor (Selection Grade) at the Department of Life Sciences, Kristu Jayanti College, Autonomous, Bengaluru. He holds a Ph.D. in Life Sciences from Kannur University, Kerala, India. During his doctoral studies, he received junior and senior research fellowships from the Council for Scientific and Industrial Research (CSIR), Government of India, having achieved an impressive All India Rank (AIR) of 60 in the CSIR-JRF/NET exam.
His doctoral research led to the successful identification of a vaccine candidate against Methicillin-resistant Staphylococcus aureus infections. His primary research interest lies in exploring interventions for diagnosing and treating infectious diseases, with a focus on rational drug discovery. He is also actively involved in collaborative research in materials science for biomedical applications. Dr. Dileep has established himself as a prolific academic author, with publications including high-impact journal articles, edited books, conference publications, book chapters, and popular science articles. He serves as the editor of the Kristu Jayanti Journal of Core and Applied Biology, a biannual journal published by the Department of Life Sciences at Kristu Jayanti College, Autonomous. In recognition of his expertise, Dr. Dileep holds several prestigious positions. He is a life member of the Kerala Academy of Sciences and serves on the research advisory committee of Kristu Jayanti College, Autonomous. He is also a member of the board of studies in Biotechnology at Jyoti Nivas College, Autonomous, Bengaluru. From 2020-2023, he served as the coordinator of the DBT-Star College Scheme at Kristu Jayanti College, Autonomous.
Dr. Sabu Abdulhameed is currently working as Professor at the Department of Biotechnology and Microbiology, Kannur University, India. He received his Ph.D. from Cochin University of Science and Technology and joined the Biotechnology Division of CSIR-NIIST, Thiruvananthapuram as a Scientist Fellow. He has engaged in postdoctoral research work in microbial fermentation and biotransformation in the USA and France. His research interests are in microbial fermentation, therapeutic enzymes, and the biotransformation of bioactive molecules. He has contributed extensively to fermentation and biotransformation in medicated wines and has three patents to his credit. Dr. Sabu has published six books and nearly 100 research papers in international journals. He is a recipient of a postdoctoral fellowship from the Institute for Research and Development (IRD, France) and a Visiting Professorship from the Mexican Agency for International Cooperation and Development. He is also a member of many academic bodies and expert panels and serves on the editorial boards of numerous research journals. He served as Pro-Vice Chancellor of Kannur University and currently Prof. Sabu is deputed to Kerala State Council for Science Technology and Environment since January 2021 as Member Secretary.
Dr. Jayachandran K. is currently working as a Professor at the School of Biosciences, Mahatma Gandhi University, India. He has completed his tenure of three years as a member of the State Environment Impact Assessment Authority( SEIAA) from 2018- 2021. Prof. Jayachandran also served as a member of many academic bodies, such as the academic council of Mahatma Gandhi University and the senate of Cochin University and Science and Technology, besides being a member of the Syndicate of Mahatma Gandhi University for two years. A professor with more than twenty-five years of teaching and research experience in the field of Biotechnology and Bioprocess, Prof. Jayachandran has published more than sixty international scientific papers in peer-reviewed journals. He has been awarded one Indian patent as one of the inventors of a novel Bioreactor. Fifteen students have completed their PhD under his guidance. His research focuses on the area of Enzyme Biotechnology, particularly in the production and characterisation of Microbial Enzymes, Quorum Sensing and Biotransformation. Currently, he is working with bacterial enzymes such as beta-glucosidase, esterase and squalene hopene cyclase. Prof.Jayachandran has completed many externally funded projects and has contributed many book chapters in the field of Biotechnology.
