781 pages | 228 B/W Illus.
Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides practical approaches to complex formulation problems encountered in the development of particulate delivery systems at the micro- and nano-size level. Completely revised and expanded to represent the most up-to-date studies in the field, this guide covers advances in pulsatile delivery systems, injectable microparticulate systems, and site-specific delivery systems, as well as potential therapeutic applications of nanotechnology.
Methods of Encapsulation and Advances in Production Technology. Biodegradable microspheres: Advances in production technology. Advances in the technology for controlled release pesticide formulations. Multiparticulate pulsatile drug delivery systems. Microencapsulation techniques for parenteral depot systems and their application in the pharmaceutical industry. Coupling methods to obtain ligand-targeted liposomes and nanoparticles. Industrial technologies and scale up. Evaluation and Characterization of Micro- and Nanoparticulate Drug Delivery Systems. Drug release from microparticulate systems. Manufacture, characterization and applications of solid lipid nanoparticles as drug delivery systems. Amphiphilic cyclodextrins and microencapsulation. Lipospheres for controlled delivery of substances. Pharmaceutical aspects of liposomes: Academic and industrial research and development. Microemulsions for solubilization and delivery of nutraceuticals and drugs. Applications of Particulate Delivery Systems. Self-emulsifying oral lipid-based formulations for improved delivery of lipophilic drugs. Recent advances in heparin delivery. Particulate systems for oral drug delivery. Vesicles as a tool for dermal and transdermal delivery. Lipid and polymeric colloidal carriers for ocular drug delivery. The use of drug-loaded nanoparticles in cancer chemotherapy. Development of 5-FU-loaded PLGA microparticles for the treatment of glioblastoma. Nanoparticulates as drug delivery systems for the brain. Cosmetic applications of colloidal delivery systems