Microextraction Techniques in Analytical Toxicology  book cover
1st Edition

Microextraction Techniques in Analytical Toxicology

Edited By

Rajeev Jain


Ritu Singh

ISBN 9780367651947
Published January 7, 2022 by CRC Press
268 Pages 15 Color & 24 B/W Illustrations

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Book Description

Microextraction Techniques in Analytical Toxicology provides the information readers need to include about cutting-edge sample preparation techniques into their everyday analytical practice, including comprehensive information about principles and state-of-the-art microextraction sample preparation techniques for the analysis of drugs and poisons in biological specimens, especially in forensic and clinical settings.

This book also focuses on theoretical discussions of solid-based and liquid-based microextraction techniques, their method development, validation, and applications. A detailed compilation of analytical protocols based on published microextraction procedures to aid in method development, synthesis, and the application of green solvents (ionic liquids and deep eutectic solvents) and new sorbents, such as molecularly imprinted polymers, and their application in microextraction techniques are also covered.


  • Provides a systematic review of microextraction techniques applied in analytical toxicology
  • A comprehensive guide for the practical implementation of microextraction techniques in forensic, clinical, and analytical laboratories
  • Contains figures and tables for easy understanding and quick adaptation of the parameters of microextraction techniques
  • Fundamentals, development, and applications of microextraction techniques as a sample preparation procedure are discussed in detail
  • Extremely useful for the researchers and academicians engaged in analytical method development using microextraction techniques

This book appeals to a wide readership of forensic, clinical, and analytical toxicologists, as well as academicians and researchers. Written by eminent scientists and leading experts on sample preparation techniques, this book serves as a desk reference for routine laboratory analysis and as an indispensable teaching tool in the classroom for graduate and Ph.D. students.

Table of Contents

Microextraction Techniques in Analytical Toxicology: An Overview

Rajeev Jain*, Ritu Singh, and Abuzar Kabir

Applications of Solid Phase Microextraction in Analytical Toxicology

Rakesh Roshan Jha and Rajeev Jain*

Applications of Micro Solid-Phase Extraction in Analytical Toxicology

Shahram Seidi* and Maryam Rezazadeh

Stir-Bar Sorptive Extraction in Analytical Toxicology Studies

Natasa P. Kalogiouri, Elissavet-Ioanna Diamantopoulou, and Victoria F. Samanidou*

Microextraction by Packed Sorbent

Tiago Rosado, Eugenia Gallardo, Duarte Nuno Vieira, and Mario Barroso*

Thin-Film Solid-Phase Microextraction: Applications in Analytical Toxicology

Lucas Morés, Josias Merib, and Eduardo Carasek*

Application of Single Drop Microextraction in Analytical Toxicology

Archana Jain and Krishna K. Verma

Applications of Liquid-Phase Microextraction in Analytical Toxicology

María Ramos Payán*, Samira Dowlatshah, and Mohammad Saraji

Dispersive Liquid-Liquid Microextraction and its variants

Rakesh Roshan Jha*, Rabindra Singh Thakur, and Rajeev Jain

Electromembrane Extraction in Analytical Toxicology

Marothu Vamsi Krishna*, Kantamaneni Padmalatha, and Gorrepati Madhavi

Fabric Phase Sorptive Extraction in Analytical Toxicology

N. Manousi, A. Kabir, and G. Zachariadis*

Sorbent-Based Microextraction using Molecularly Imprinted Polymers

Cecilia Ortega-Zamora, Gabriel Jiménez-Skrzypek, Javier González-Sálamo, and Javier Hernández-Borges*

Applications of Ionic Liquids in Microextraction

Devendra Kumar Patel*, Neha Gupta, Sandeep Kumar, and Juhi Verma

Deep Eutectic Solvent based Microextraction

Amir M. Ramezani, Yadollah Yamini* and Raheleh Ahmadi

Hyphenation of Derivatization with Microextraction Techniques in Analytical Toxicology

Abhishek Chauhan* and Utkarsh Shukla

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Dr. Rajeev Jain is Senior Scientist of Forensic Toxicology at Central Forensic Science Laboratory, Ministry of Home Affairs, Govt. of India. He has more than 10 years of research experience in the field of analytical toxicology. During his tenure as Forensic Toxicologists, he has examined post-mortem samples of more than 500 medico-legal cases pertaining to drug overdose and poisoning. He has obtained his Ph.D. degree in Analytical Toxicology from CSIR-Indian Institute of Toxicology Research (India). His research work is focused on Development of simple, rapid, eco-friendly, cost-effective, sensitive and selective analytical methods based on microextraction techniques (such as SPME and DLLME etc.) for the determination of chemical analytes for forensic toxicological, clinical and environmental importance in various complex samples such as blood, saliva, plasma, urine, tissue etc. using GC-MS, GC-FID, HPLC, GC-ECD and TLC-image processing technique. He has published many research papers, review papers and book chapters in various referred journals on this subject. He was one of the first scientists to explore the possibility of coupling dispersive liquid-liquid microextraction with injector port silylation for rapid analysis of polar toxicants. He is also acting as invited reviewer in various referred journals and on the editorial board of various open access journals of Toxicology and Chromatography.

Dr. Ritu Singh is an Assistant Professor in Department of Environmental Science, School of Earth Sciences, Central University of Rajasthan, Rajasthan, India. Her research interest includes analytical method development, microextraction techniques, nano-remediation, environmental monitoring and assessment. She received her doctorate degree in Environmental Science from Babasaheb Bhimrao Ambedkar University, Lucknow. She worked as research fellow in CSIR-Indian Institute of Toxicology Research for five years and made significant contribution in the field of nano-remediation. She has published her work in several international journals of repute and has contributed several chapters in international and national books. She also has one international book to her credit. She is the recipient of ‘DEF-Young Scientist Award’ in the field of Environmental Science. She is an editorial board member of Journal of Nanoscience, Nanoengineering and Applications, Journal of Water Pollution & Purification Research & Eurasian Journal of soil science. and invited reviewer of several refereed journals. She is also serving as life member of various academic bodies.