1st Edition

Microheterogeneity of Glycoprotein Hormones

By B.A. Keel Copyright 1989

    Eleven contributions review our knowledge of the characterization of glycoprotein hormone microheterogeneity, the relationships between biological activity and microheterogeneity, the endocrinological control mechanisms involved in the production of these forms and the underlying biochemical basis for glycoprotein hormone microheterogeneity. Organized so that the heterogeneity of each hormone from a variety of species is covered in detail, the peptide components and oligosaccaride stuctures of glycoprotein hormones are reviewed, and the heterogeneity of uncombined alpha and beta subunits is discussed.

    1. Chemistry of the Peptide Components of Glycoprotein Hormones 2. Oligosaccharide Structures of the Anterior Pituitary and Placental Glycoprotein Hormones 3. Occurrence and Properties of Glycoprotein Hormone Free Subunits 4. Charge Homogeneity of Human Luteinizing Hormone Does Not Implicate Charge Homogeneity of its Subunits 5. Prolactin Microheterogeneity 6. Follicle-Stimulating Hormone Microheterogeneity 7. Follicle-Stimulating Hormone Structure-function Relationships 8. Luteinizing Hormone Microheterogeneity 9. Equine Luteinizing Hormone Microheterogeneity 10. Thyroid-Stimulating Hormone Microheterogeneity 11. Human Chorionic Gonadotropin Microheterogeneity


    Keel, B.A.