Microspheres and microcapsules have very broad applications in various fields, especially in those of biotechnology and biopharmaceuticals, as targeting drug–delivery carriers, separation media for protein, peptide, DNA, and so forth. It is a big challenge to design and prepare microspheres and microcapsules of different sizes and structures from various materials and develop new techniques.
This book focuses on new microspheres and microcapsules specifically designed and prepared for application in the fields of biotechnology and biopharmaceuticals involving bioreaction, bioseparation, bioformulation, biodetection, and other new bioapplications. It provides a deep knowledge about the principles of design, preparation methods, and application results of new microspheres and microcapsules for each bioapplication area. The book also presents problems that need to be studied further and comments on the future prospects of microspheres and microcapsules.
Table of Contents
Microspheres for Enzyme Immobilization
Microspheres for Cell Culture
Microcapsules for Cell Transplantation: Design, Preparation and Application
Microspheres for the Separation and Refolding of Proteins with an Emphasis on Particles Made of Agarose
Microspheres for Separation of Bioactive Small Molecules
Microspheres for Separation of PEG-modified Biomolecules
Microspheres for Solid Phase Organic Synthesis
Microspheres for Solid-phase Modification of Proteins
Microspheres and Microcapsules for Protein Drug Delivery
Micro/nanopheres for Gene Drug Delivery
Microsphere for Targeting Delivery of Anti-cancer Drug
Microsphere for Targeting Delivery to Brain
Nano/microsphere in Bioimaging and Medical Diagnosis
Design, Preparation and Application of Affinity Latex For Diagnosis and Bioassay
Guanghui Ma received her Bachelor’s degree in polymer engineering at Gunma University, Gunma, Japan, in 1988. She obtained her MSc in 1990 and PhD degree in 1993 in polymer chemistry from Tokyo Institute of Technology, Japan. After a year as a research fellow at Tokyo Institute of Technology, she was appointed assistant professor in the Department of Chemical Engineering, Tokyo University of Agriculture and Technology, Japan, in 1994, and assistant professor in the Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology in 1996. In 2001, she was appointed professor at the Institute of Process Engineering (IPE), Chinese Academy of Sciences, Beijing, China. Currently she is the vice president of IPE , director of the National Engineering Research Center for Biotechnology (Beijing), and editorial board member of Journal of Microencapsulation and Particuology.
Prof. Ma’s research interest includes biomaterials and bioformulations. Her expertise lies in the preparation of uniform-sized and structure-controllable microspheres and microcapsules for bioseparation media, controlled release carriers, enzyme immobilization and vaccine adjuvants, with 150 peer-reviewed papers in international journals, 6 English and 3 Chinese scientific books, and a number of book chapters. She also has more than 20 patents and collaborations with industry for technology applications. She received several awards in science and technology, including Science and Technology Prize 2005 of Beijing, National Technological Invention Prize 2009 of China, and Asian Regional Young Women Researcher Award 2009 from TWAS-TWOWS-SCOPUS.
Professor Zhiguo Su received his bachelor’s degree in chemical engineering from Dalian University of Technology (DUT), Dalian, China, in 1982 and PhD in biochemical engineering from the University of Manchester, England, in 1985. After a year as a postdoctoral fellow at Delft University of Technology, the Netherlands, in 1986, he became a lecturer of DUT in 1987, associate professor in 1988, and professor in 1991. He was a visiting scientist at the Massachusetts Institute of Technology, USA, in 1990 and 1992–1993. Currently he is the director of the National Key Laboratory of Biochemical Engineering and Professor at Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China. Prof Su’s research interest focuses on biomolecular and bioprocess engineering. He has been responsible for several major research projects on biopharmaceutical process technologies in China over the past few years, including production of hepatitis B vaccine, pegylated cytokines, and modified hemoglobin as blood substitutes. He has published more than 160 papers in international journals on protein refolding, modification and drug delivery. He was a committee member of a number of international conferences and serves as the editorial board member of Artificial Cells, Blood Substitutes and Biotechnology and Journal of Chemical Technology and Biotechnology and the associate editor of Chinese Journal of Biotechnology.
"There has been an ever-increased interest in novel functional microspheres and microcapsules over recent years. This book presents state-of-the-art studies on developing microspheres and microcapsules for various applications in bioprocessing, drug delivery, and medicine, including the authors’ own research, which is an excellent source to inspire scientists and engineers in this area."
—Prof. Zhibing Zhang, University of Birmingham, UK
"Focusing on applications to biotechnology, this book discusses the recent developments in the principles of design and preparation methodology of microspheres and microcapsules and those of novel results and information obtained by experts of each subject. The readers can find detailed routes from basic chemistry to various biological and medical applications in this book. The selected topics should be of particular interest to readers who belong to research facilities in companies and universities treating bio-related subjects at the cutting edge."
—Prof. Toshiaki Dobashi, Gunma University, Japan
"This book provides a snapshot of how to design and prepare microspheres and microcapsules specifically for bio-related applications. The diverse topics covered are actively investigated with contributions from leading experts in the field. I believe this book will serve to provide a background for researchers and graduate students working in this interesting field and also be a source of inspiration for future work in this discipline."
—Prof. To Ngai, The Chinese University of Hong Kong, Hong Kong