Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.
Table of Contents
Pharmaceutical and Methodological Aspects of Microparticles (Y. Chen, M.A. Burton, and B.N. Gray). Blood Flow and Its Modulation in Malignant Tumors (D.G. Hirst). Microparticulate Carriers as a Therapeutic Option in Regional Cancer Therapy: Clinical Considerations (J.H. Anderson, C.S. McArdle, and T.G. Cooke). Magnetically Controlled Targeted Chemotherapy (P.K. Gupta and C.T. Hung). Agents for Microsphere Incorporation: Physicochemical Considerations and Physiological Consequences of Particle Embolization (N. Willmott). Drug Analysis of Protein Microspheres: From Pharmaceutical Preparation to In Vivo Fate (J. Cummings, D. Watson, and J.F. Smyth). Regional Therapy of Liver Metastases: A Surgeon's View (H.J. Gallagher and J.M. Daly). Evaluation of the Potential of Microspherical Systems for Regional Therapy in the Tumor Bearing Liver and Kidney Using Techniques in Nuclear Medicine (J.A. Goldberg, J.H. McKillop, and C.S. McArdle). Perspective on Microspheres in Regional Cancer Therapy (N. Willmott, B.N. Gray, and J.M. Daly).
Oncology Research Celltech, Ltd. Slough, United Kingdom. Department of Surgery Hospital of the University of Pennsylvania Philadelphia, Pennsylvania.