Mineral and Metal Neurotoxicology: 1st Edition (Hardback) book cover

Mineral and Metal Neurotoxicology

1st Edition

By Masayuki Yasui, M. Anthony Verity

CRC Press

480 pages

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Hardback: 9780849376641
pub: 1996-09-26
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Trace minerals and metals such as zinc, copper, and magnesium are accepted as a "natural" part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues regarding the relationship between mineral-metal interactions and neurological disorders. The most current information and latest advancements in neurotoxicology and environmental science are presented by experts from around the world.

Part I addresses general aspects of minerals and metals and covers environmental aspects and research techniques. Part II describes specific minerals and metals related to experimental and clinical neurological disorders. The roles of metals and minerals in specific disorders and diseases are discussed in detail, including Alzheimer's disease and aluminum, mercury-related neurological syndromes and disorders, manganese-induced Parkinsonism, and many other CNS disorders.

Table of Contents



Introduction and Background

Man, Metals, and Minerals, J.H. Menkes

Environmental Aspects

Neurotoxic Metals in the Environment: Some General Aspects, T.P. Flaten

Effects of Acid Rain: A Natural Model of Aluminum Toxicity in Fish, R.M. Garruto, T.P. Flaten, and I. Wakayama

Cellular Aspects of Aluminum Toxicity in Plants, A.R. Haug and V. Vitorello

Recent Concept of Minerals/Metals Research

Determination of Trace Elements in Biological Samples - Neutron Activation Analysis, Z.B. Alfassi and M. Yasui

Axonal Transport of Neurotoxic Metals, B. Arvidson



Chemistry of Aluminum in the CNS, R.B. Martin

The Metabolism and Toxicokinetics of Aluminum Relevant to Neurotoxicology, R.A. Yokel

Aluminum: On Both Sides of the Blood-Brain Barrier, R. Deloncle and N. Pages

Modeling of Acute and Chronic Aluminum Neurotoxicity, M.J. Strong

Motor Neuron Disease, M.J. Strong and R.M. Garruto

Alzheimer's Disease and Aluminum, W.J. Lukiw

Dialysis Encephalopathy, A.C. Alfrey


Role of Zinc in the CNS, M. Yasui, K. Ota, and V.A. Murphy

Zinc-Toxicity in Alzheimer's Disease: An Emerging Hypothesis, J. Constantinidis


Pathogenesis of Methyl Mercury Neurotoxicity, M.A. Verity

Mercury-Related Neurological Syndromes and Disorders, L.W. Chang

Neurotoxicity of Methylmercury: Minamata and the Amazon, M. Harada

Minimata Disease in Niigata: Epidemiology and Legal-Social Issues, K. Kondo


Mechanisms of Action on Nervous System in Magnesium Deficiency and Dementia, J. Durlach and P. Bac

Regulation of Cell Minerals and its Therapeutic Use, M. Bara

Magnesium-Related Neurological Disorders, M. Yasui, K. Ota, and V.A. Murphy


Cadmium: Acute and Chronic Neurological Disorders, V.A. Murphy


Interactions Between Lead and Metals in Cellular Toxicity, T.J.B. Simons

Molecular Interactions Between Lead and Magnesium Ions, D. Srivastava and D.A. Fox

Inorganic Lead, Neurotransmitters, and Neuropeptides, N. Pages and R. Deloncle

Epidemiologic Approaches to Characterizing the Developmental Neurotoxicity of Lead, D.C. Bellinger

Efforts to Reduce Lead Exposure in the United States, J.M. Davis, R.W. Elias, and L.D. Grant


Relationships Between Manganese and Other Minerals, J.C.K. Lai, A.W.K. Chan, M.J. Minski, and L. Lim

Manganese Dynamics in Brain Mitochondria, C.E. Gavin and T.E. Gunter

Implications of Manganese in Disease, Especially CNS Disorders, E. Heilbronn and H. Eriksson

Manganese-Induced Parkinsonism, E.C. Wolters


The Involvement of Intracellular Calcium in Amyotrophic Lateral Sclerosis, M.I. Hasham and C. Krieger

Spinal Canal Stenosis Secondary to Calcium Crystal Deposition Disease: Relationship Between Neurologic Symptoms and Locations of Crystal Deposition, M. Yoshida, T. Tamaki, and Y. Taniguchi

Epilepsy, Calcium, and Minerals, E.J. Waterhouse and R.J. DeLorenzo

A Possible Role of Calcium on Neurotransmitters and Biogenic Amines in CNS, K. Ota


Alterations in Iron in Neurodegenerative Disorders: Implications and Possible Therapeutic Agents, D.T. Dexter and P. Jenner

Lamma Studies of Iron, Oxidative Stress, and Neuroprotective Strategies in Parkinson's Disease, P.F. Good, C.W. Olanow, and D.P. Perl


Copper/Zinc Superoxide Dismutases in Familial Amyotrophic Lateral Sclerosis: Tyrosine Nitration Catalysis as a Possible Mutational Gain in Function, J.B. Sampson, J.P. Crow, M.J. Strong, and J.S. Beckman

The Role of Ceruloplasmin for Iron and Copper Metabolism in CNS Disorders, H. Morita and N. Yanagisawa

Treatment of Wilson's Disease and Metal Metabolic Interactions, G.J. Brewer

Neuropsychological Characteristics in Wilson's Disease, H. Hefter

Copper Localization in the CNS of Wilson's Disease, M. Yasui and K. Ota

Menkes' Kinky Hair Disease, T. Yamano and M. Shimada

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Neurology
MEDICAL / Toxicology
TECHNOLOGY & ENGINEERING / Industrial Health & Safety