Mineral and Metal Neurotoxicology  book cover
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Mineral and Metal Neurotoxicology




ISBN 9780849376641
Published September 26, 1996 by CRC Press
480 Pages

 
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Book Description

Trace minerals and metals such as zinc, copper, and magnesium are accepted as a "natural" part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues regarding the relationship between mineral-metal interactions and neurological disorders. The most current information and latest advancements in neurotoxicology and environmental science are presented by experts from around the world.
Part I addresses general aspects of minerals and metals and covers environmental aspects and research techniques. Part II describes specific minerals and metals related to experimental and clinical neurological disorders. The roles of metals and minerals in specific disorders and diseases are discussed in detail, including Alzheimer's disease and aluminum, mercury-related neurological syndromes and disorders, manganese-induced Parkinsonism, and many other CNS disorders.

Table of Contents

GENERAL ASPECTS OF MINERALS
AND METALS
Introduction and Background
Man, Metals, and Minerals, J.H. Menkes
Environmental Aspects
Neurotoxic Metals in the Environment: Some General Aspects, T.P. Flaten
Effects of Acid Rain: A Natural Model of Aluminum Toxicity in Fish, R.M. Garruto, T.P. Flaten, and I. Wakayama
Cellular Aspects of Aluminum Toxicity in Plants, A.R. Haug and V. Vitorello
Recent Concept of Minerals/Metals Research
Determination of Trace Elements in Biological Samples - Neutron Activation Analysis, Z.B. Alfassi and M. Yasui
Axonal Transport of Neurotoxic Metals, B. Arvidson
SPECIFIC MINERALS AND METALS RELATED TO EXPERIMENTAL AND CLINICAL NEUROTOXICOLOGY
Aluminum
Chemistry of Aluminum in the CNS, R.B. Martin
The Metabolism and Toxicokinetics of Aluminum Relevant to Neurotoxicology, R.A. Yokel
Aluminum: On Both Sides of the Blood-Brain Barrier, R. Deloncle and N. Pages
Modeling of Acute and Chronic Aluminum Neurotoxicity, M.J. Strong
Motor Neuron Disease, M.J. Strong and R.M. Garruto
Alzheimer's Disease and Aluminum, W.J. Lukiw
Dialysis Encephalopathy, A.C. Alfrey
Zinc
Role of Zinc in the CNS, M. Yasui, K. Ota, and V.A. Murphy
Zinc-Toxicity in Alzheimer's Disease: An Emerging Hypothesis, J. Constantinidis
Mercury
Pathogenesis of Methyl Mercury Neurotoxicity, M.A. Verity
Mercury-Related Neurological Syndromes and Disorders, L.W. Chang
Neurotoxicity of Methylmercury: Minamata and the Amazon, M. Harada
Minimata Disease in Niigata: Epidemiology and Legal-Social Issues, K. Kondo
Magnesium
Mechanisms of Action on Nervous System in Magnesium Deficiency and Dementia, J. Durlach and P. Bac
Regulation of Cell Minerals and its Therapeutic Use, M. Bara
Magnesium-Related Neurological Disorders, M. Yasui, K. Ota, and V.A. Murphy
Cadmium
Cadmium: Acute and Chronic Neurological Disorders, V.A. Murphy
Lead
Interactions Between Lead and Metals in Cellular Toxicity, T.J.B. Simons
Molecular Interactions Between Lead and Magnesium Ions, D. Srivastava and D.A. Fox
Inorganic Lead, Neurotransmitters, and Neuropeptides, N. Pages and R. Deloncle
Epidemiologic Approaches to Characterizing the Developmental Neurotoxicity of Lead, D.C. Bellinger
Efforts to Reduce Lead Exposure in the United States, J.M. Davis, R.W. Elias, and L.D. Grant
Manganese
Relationships Between Manganese and Other Minerals, J.C.K. Lai, A.W.K. Chan, M.J. Minski, and L. Lim
Manganese Dynamics in Brain Mitochondria, C.E. Gavin and T.E. Gunter
Implications of Manganese in Disease, Especially CNS Disorders, E. Heilbronn and H. Eriksson
Manganese-Induced Parkinsonism, E.C. Wolters
Calcium
The Involvement of Intracellular Calcium in Amyotrophic Lateral Sclerosis, M.I. Hasham and C. Krieger
Spinal Canal Stenosis Secondary to Calcium Crystal Deposition Disease: Relationship Between Neurologic Symptoms and Locations of Crystal Deposition, M. Yoshida, T. Tamaki, and Y. Taniguchi
Epilepsy, Calcium, and Minerals, E.J. Waterhouse and R.J. DeLorenzo
A Possible Role of Calcium on Neurotransmitters and Biogenic Amines in CNS, K. Ota
Iron
Alterations in Iron in Neurodegenerative Disorders: Implications and Possible Therapeutic Agents, D.T. Dexter and P. Jenner
Lamma Studies of Iron, Oxidative Stress, and Neuroprotective Strategies in Parkinson's Disease, P.F. Good, C.W. Olanow, and D.P. Perl
Copper
Copper/Zinc Superoxide Dismutases in Familial Amyotrophic Lateral Sclerosis: Tyrosine Nitration Catalysis as a Possible Mutational Gain in Function, J.B. Sampson, J.P. Crow, M.J. Strong, and J.S. Beckman
The Role of Ceruloplasmin for Iron and Copper Metabolism in CNS Disorders, H. Morita and N. Yanagisawa
Treatment of Wilson's Disease and Metal Metabolic Interactions, G.J. Brewer
Neuropsychological Characteristics in Wilson's Disease, H. Hefter
Copper Localization in the CNS of Wilson's Disease, M. Yasui and K. Ota
Menkes' Kinky Hair Disease, T. Yamano and M. Shimada

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