Mitochondria in Health and Disease: 1st Edition (Paperback) book cover

Mitochondria in Health and Disease

1st Edition

Edited by Carolyn D. Berdanier

CRC Press

640 pages

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Description

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Table of Contents

Preface. Introduction to Mitochondria. Bioenergetics of Mitochondria. Mitochondrial Genome and Mitochondrial Function. Mitochondrial Diseases in Growth and Development. Using Mitochondria in Population Surveys. Mitochondrial DNA Mutation, Oxidative Stress and Alterations of Gene Expression in Human Aging. Mitochondrial Mutations in Vision. Mitochondrial DNA in Cardiomyopathies. Mitochondria in Diabetes. Drugs, Nutrients and Hormones in Mitochondrial Function. Bacterial F1F0ATP Synthase as a Model for Complex V. Cybrids and the Manipulation of Mitochondrial Genotype. Animal Modeling: From Transgenics to Transmitochondrial Models. BHE/Cdb Rats as Tools to Study Mitochondrial Mutation.

About the Editor

Carolyn D. Berdanier

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED060000
MEDICAL / Nutrition
SCI017000
SCIENCE / Life Sciences / Cytology
SCI086000
SCIENCE / Life Sciences / General