1st Edition

Mitochondria in Liver Disease

Edited By Derick Han, Neil Kaplowitz Copyright 2016
    511 Pages
    by CRC Press

    511 Pages
    by CRC Press

    "…excellent, well-organized, and timely."
    —Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface

    The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.

    The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion–fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system.

    Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

    OVERVIEW OF MITOCHONDRIA. Metabolism of Superoxide Radical and Hydrogen Peroxide in the Mitochondria. Energy-Redox Axis in Mitochondria: Interconnection of Energy-Transducing Capacity and Redox Status. Signal Transduction Pathways That Regulate Mitochondrial Gene Expression. Transcriptional Regulation of Mitochondrial Biogenesis and Quality Control. Mitochondria in Liver Disease: Regulation of Liver Mitochondrial Function by Hydrogen Sulfide. Impact of Aging and Calorie Restriction on Liver Mitochondria. Drug Delivery to Mitochondria: A Promising Approach for the Treatment of Liver Disease. ROLE OF MITOCHONDRIA IN LIVER DISEASES. Central Role of Mitochondria in Drug-Induced Liver Injury. Role of Autophagy and Mitophagy in Liver Diseases. Mitochondrial Dynamics, Mitophagy and Mitochondrial Spheroids in Drug-Induced Liver Injury. Biomarkers of Mitochondrial Damage in the Liver. Alterations of Mitochondrial DNA in Liver Diseases. Epigenetic Modifications of Mitochondrial DNA in Liver Disease: Focus on Nonalcoholic Fatty Liver Disease. Emerging Role of Mitochondrial Dynamics in Viral Hepatitis. Mitochondrial Dynamics and Liver Metabolism. Role of JNK in Lipotoxicity in the Liver. Mitochondrial Function, Dysfunction, and Adaptation in the Liver during the Development of Diabetes. Mitochondrial Dynamics and Adaptation in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease. Acid Sphingomyelinase, Mitochondria, and Liver Diseases. Regulation of Liver Metabolism by Sirtuins: Emerging Roles.


    Derick Han is an assistant professor in the Department of Biopharmaceutical Science at the School of Pharmacy, Keck Graduate Institute, Claremont, California, a member of The Claremont Colleges. He earned his PhD in molecular pharmacology and toxicology from the School of Pharmacy at the University of Southern California. His research focuses on mitochondrial remodeling in the liver caused by metabolic stress, such as alcohol. He is also interested in mitochondrial reprogramming that occurs in cancer cells. He has published more than 70 research publications, reviews, and book chapters.

    Neil Kaplowitz, MD, is director of the University of Southern California’s Research Center for Liver Diseases, Los Angeles. He is the Brem Professor of Medicine, the Budnick Chair in Liver Diseases, and the chief of the Division of Gastrointestinal and Liver Diseases. He is also a professor of physiology and biophysics and pharmacology and pharmaceutical sciences at the Keck School of Medicine at the University of Southern California. Dr. Kaplowitz has received a number of honors and distinctions and has served as president of the American Association for the Study of Liver Diseases and as vice chair for research at the American Liver Foundation. He has also been as associate editor of several journals, including Hepatology, Gastroenterology, and the American Journal of Physiology. He has published more than 195 peer-reviewed scientific articles and 150 scholarly reviews and has edited 10 books on liver diseases.