Modelling Metabolism with Mathematica: 1st Edition (Paperback) book cover

Modelling Metabolism with Mathematica

1st Edition

By Peter Mulquiney, Philip W. Kuchel

CRC Press

328 pages

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With the advent of sophisticated general programming environments like Mathematica, the task of developing new models of metabolism and visualizing their responses has become accessible to students of biochemistry and the life sciences in general. Modelling Metabolism with Mathematica presents the approaches, methods, tools, and algorithms for modelling the chemical-dynamics of metabolic pathways. The authors explain the concepts underpinning the deterministic theory of chemical and enzyme kinetics, present a graded series of computer models of metabolic pathways leading up to that of the human erythrocyte, and document a consistent set of rate equations and associated kinetic parameters.

The experimental and theoretical study of metabolism in mammalian cells has a long and fruitful history, but our understanding of cellular metabolism at the molecular level is far from complete. This book enables its readers to formulate their own models of time-dependent metabolic systems and aids them in the quest for the many fundamental and clinically relevant discoveries that remain to be made.

Table of Contents

Introduction to Chemical Kinetics and Numerical Integration. Elements of Enzyme Kinetics. Basic Procedures for Simulating Metabolic Systems. Advanced Simulation of Metabolic Pathways. Metabolic Control Analysis. Parameter Estimation. Model of Red Cell Metabolism. Metabolic Control Analysis of Human Erythrocyte Metabolism. Appendices.

About the Authors

Mulquiney, Peter; Kuchel, Philip W.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Hematology
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Life Sciences / General