Modern Methods in Carbohydrate Synthesis: 1st Edition (Paperback) book cover

Modern Methods in Carbohydrate Synthesis

1st Edition

By Shaheer H. Khan

CRC Press

576 pages

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Description

Modern Methods in Carbohydrate Synthesis presents in one volume a sequence of chapters leading from classical methods through to today's newest state-of -the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of increasingly important glycosidic linkage analogs, as well as the oligosaccharides containing derivatives and analogs of natural sugars are included. While chemical-synthetic methods constitute the major part of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis, also covering combined chemical and enzymatic synthesis.

Chapters are written by leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.

Table of Contents

Foreword

Preface

List of contributors

1. Twenty Five Years of Carbohydrate Chemistry; An Overview of Oligosaccharide Synthesis

Hans Paulsen

2. The Anomeric O-Alkylation and the Trichloroacetimidate Method - Versatile Strategies for Glycoside Bond Formation

Richard R. Schmidt

3. Synthesis of Glycosyl Halides for Oligosaccharide Synthesis Using Dihalogenomethyl Methyl Ethers

Pavol Kovác

4. Glycosylation Properties and Reactivity of Thioglycosides, Sulfoxides, and other S-glycosides: Current Scope and Future Prospects

Thomas Norberg

5. Phenyl Selenoglycosides as Versatile Glycosylating Agents in Oligosaccharide Synthesis and the Chemical Synthesis of Disaccharides Containing Sulfur and Selenium

Seema Mehta and B. Mario Pinto

6. Synthesis and Use of S-Xanthates, Carbohydrate Enol Ethers and and Related Derivatives in the Field of Glycosylation

Pierre Sinaÿ and Jean-Maurice Mallet

7. n-Pentenyl Glycosides in Oligosaccharide Synthesis

Robert Madsen and Bert Fraser-Reid

8. Coupling of Glycals: A New Strategy for the Rapid Assembly of Oligosaccharides

Mark T. Bilodeau and Samuel J. Danishefsky

9. Advances in Polymer-Supported Solution Synthesis of Oligosaccharides

Jiri J. Krepinsky

10. Protecting Groups in Oligosaccharide Synthesis

T. Bruce Grindley

11. Synthesis of ß-D-Mannose Containing Oligosaccharides

Frank Barresi and Ole Hindsgaul

12. Synthesis of Sialoglycoconjugates

Akira Hasegawa

13. Synthetic Studies on Cell-Surface Glycans: An Approach to O-linked Sialoglycoprotein

Yoshiaki Nakahara, Hiroyuki Iijima and Tomoya Ogawa

14. Synthesis of C-Glycosides; Stable Mimics of O-Glycosidic Linkages

Carolyn Bertozzi and Mark Bednarski

15. Recent Developments in Glycopeptide Synthesis

Stefan Peters, Morten Meldal and Klaus Bock

16. Design and Synthesis of Glycoconjugates

René Roy

17. Synthesis of Biologically Active Sulfated and Phosphorylated Oligosaccharides

Wasimul Haque and Robert M. Ippolito

18. Synthetic Glycosyltransferase Acceptors and Inhibitors; Useful Tools in Glycobiology

Khushi L. Matta

19. Practical Synthesis of Oligosaccharides Based on Glycosyltransferases and Glycosylphophites

Chi-Huey Wong

20. Use of Glycosyltransferases in the Synthesis of Unnatural Oligosaccharide Analogues

Suzanne C. Crawley and Monica M. Palcic

21. Synthesis with Glycosidases

Kurt G.I. Nilsson

Index

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013040
SCIENCE / Chemistry / Organic