2nd Edition

Molecular Biology Structure and Dynamics of Genomes and Proteomes

By Jordanka Zlatanova Copyright 2023
    732 Pages 688 Color Illustrations
    by Garland Science

    732 Pages 688 Color Illustrations
    by Garland Science

    732 Pages 688 Color Illustrations
    by Garland Science

    Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology.

    Key Features

    • Highlights the experimental basis of important discoveries in molecular biology
    • Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense
    • Provides learning objectives for each chapter
    • Includes a list of relevant videos from the Internet about the topics covered in the chapter

    Chapter 1: To the Cell and Beyond: The Realm of Molecular Biology. Chapter 2: From Classical Genetics to Molecular Genetics. Chapter 3: Proteins. Chapter 4: Nucleic Acids. Chapter 5: Recombinant DNA: Principles and Applications. Chapter 6: Protein-Nucleic Acid Interactions. Chapter 7: The Genetic Code, Genes, and Genomes. Chapter 8: Physical Structure of the Genomic Material. Chapter 9: Transcription in Bacteria. Chapter 10: Transcription in Eukaryotes. Chapter 11: Regulation of Transcription in Bacteria. Chapter 12: Regulation of Transcription in Eukaryotes. Chapter 13: Transcription Regulation in the Human Genome. Chapter 14: RNA Processing. Chapter 15: Translation: The Players. Chapter 16: Translation: The Process. Chapter 17: Regulation of Translation. Chapter 18: Protein Processing and Modification. Chapter 19: DNA Replication in Bacteria. Chapter 20: DNA Replication in Eukaryotes. Chapter 21: DNA Recombination. Chapter 22: DNA Repair. Glossary.


    Jordanka Zlatanova is Professor Emeritus of Molecular Biology at the Department of Molecular Biology at the University of Wyoming. She is a native of Bulgaria and received her MS degree in Biochemistry from the St. Petersburg's State University in Russia (1968), her Ph.D. degree from Ernst Boehringer Institute for Drug Research in Vienna, Austria and the Institute of Molecular Biology of the Bulgarian Academy of Sciences, Sofia (1980), and her Doctor of Science (D.Sc.) degree from the Institute of Genetics, Bulgarian Academy of Sciences (1989). She founded and chaired the Department of Molecular Genetics at the Institute of Genetics for nine years before moving to the United States to work as a Senior Research Professor in the laboratory of Dr. van Holde, with whom she shares an interest in chromatin structure and dynamics. After two years at the Argonne National Laboratory as a Deputy Director of the Biochip Technology Center and four years at the Department of Chemistry and Chemical Engineering at the Polytechnic Institute of NY University, she moved to Wyoming to chair the Department of Molecular Biology at the University of Wyoming.

    Dr. Zlatanova has published over 200 papers cited more than 7000 times. She has co-authored three books: Replication and Transcription of Chromatin (1992), and recently Molecular Biology; Structure and Dynamics of Genomes and Proteomes (2016) and The Evolution of Molecular Biology. The Search for the Secrets of Life (2018). These two recent books were written together with Ken van Holde. She has also co-edited two books: Biology at the Single-Molecule Level (2001) and Chromatin Structure and Dynamics: State-of-the-Art (2004). Her teaching experience includes undergraduate and graduate courses in biochemistry, molecular and cell biology, microbiology, genetics, and general biology. In addition, dr. Zlatanova has given close to 90 invited presentations in 19 countries all over the world.

    "The authors draw a seamless connection between the classical molecular and cell biology techniques and numerous recent advances…[Their] efforts toward inculcating a sense of history in every discovery and concept is nailed in every chapter." - The Yale Journal of Biology and Medicine, December 2016, Volume 89, Issue 4