Molecular Biology Structure and Dynamics of Genomes and Proteomes
Molecular Biology: Structure and Dynamics of Genomes and Proteomes second edition illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination. The text is written for advanced undergraduate or graduate-level courses in molecular biology.
- Highlights the experimental basis of important discoveries in molecular biology
- Thoroughly updated with new information on gene editing tools, viruses, and transcription mechanisms, termination and antisense
- Provides learning objectives for each chapter
- Includes a list of relevant videos from the Internet about the topics covered in the chapter
Chapter 1: To the Cell and Beyond: The Realm of Molecular Biology. Chapter 2: From Classical Genetics to Molecular Genetics. Chapter 3: Proteins. Chapter 4: Nucleic Acids. Chapter 5: Recombinant DNA: Principles and Applications. Chapter 6: Protein-Nucleic Acid Interactions. Chapter 7: The Genetic Code, Genes, and Genomes. Chapter 8: Physical Structure of the Genomic Material. Chapter 9: Transcription in Bacteria. Chapter 10: Transcription in Eukaryotes. Chapter 11: Regulation of Transcription in Bacteria. Chapter 12: Regulation of Transcription in Eukaryotes. Chapter 13: Transcription Regulation in the Human Genome. Chapter 14: RNA Processing. Chapter 15: Translation: The Players. Chapter 16: Translation: The Process. Chapter 17: Regulation of Translation. Chapter 18: Protein Processing and Modification. Chapter 19: DNA Replication in Bacteria. Chapter 20: DNA Replication in Eukaryotes. Chapter 21: DNA Recombination. Chapter 22: DNA Repair. Glossary.
"The authors draw a seamless connection between the classical molecular and cell biology techniques and numerous recent advances…[Their] efforts toward inculcating a sense of history in every discovery and concept is nailed in every chapter." - The Yale Journal of Biology and Medicine, December 2016, Volume 89, Issue 4