1st Edition
Molecular, Cellular, and Tissue Engineering
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.
Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine.
More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.
MOLECULAR BIOLOGY
Historical Perspective and Basics of Molecular Biology; Nathan R. Domagalski and Michael Domach
Biomolecular Interactions; Gordon Rule
Recent Advances in DNA Separations: Plasmid Purification, Rapid Electrophoresis, and Affinity-Based Recovery; James W. Schneider and Jeffrey M. Savard
Systems and Technology Involving Bacteria; Nicole Bleckwenn and William Bentley
Expression in Mammalian Cells; Tina Sauerwald and Michael Betenbaugh
DNA Vaccines Production and Engineering; Michael M. Domach, Jonathan W. Meade, and Mohammad A. Ataai
TRANSPORT PHENOMENA AND BIOMIMETIC SYSTEMS
Biomimetic Systems: Concepts, Design, and Emulation; Robert J. Fisher
Transport/Reaction Processes in Biology and Medicine; E. N. Lightfoot
Microvascular Heat Transfer; James W. Baish
Fluid Dynamics for Bio Systems: Fundamentals and Model Analysis; Robert A. Peattie and Robert J. Fisher
Animal Surrogate Systems; Michael L. Shuler, Sarina G. Harris, Xinran Li, and Mandy B. Esch
Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease; John M. Tarbell and Yuchen Qiu
Transport Phenomena and the Microenvironment; Robert J. Fisher and Robert A. Peattie
Transport and Drug Delivery through the Blood–Brain Barrier and Cerebrospinal Fluid; Bingmei M. Fu
Interstitial Transport in the Brain: Principles for Local Drug Delivery; W. Mark Saltzman
Surfactant Transport and Fluid–Structure Interactions during Pulmonary Airway Reopening; David Martin, Anne-Marie Jacob, and Donald P. Gaver III
PHYSIOLOGICAL MODELING, SIMULATION, AND CONTROL
Modeling Strategies and Cardiovascular Dynamics; Joseph L. Palladino, Gary M. Drzewiecki, and Abraham Noordergraaf
Compartmental Models of Physiological Systems; Claudio Cobelli, Giovanni Sparacino, Maria Pia Saccomani, Gianna Maria Toffolo, and Andrea Caumo
Cardiovascular Models and Control; Madhusudan Natarajan, Fernando Casas, and W.D. Timmons
Respiratory Models and Control; Chi-Sang Poon
Biomimetic Approaches to Physiological Control; James J. Abbas and Amit Abraham
Methods and Tools for Identification of Physiologic Systems; Vasilis Z. Marmarelis
Modeling Vascular Vibrations: Autoregulation and Vascular Sounds; Gary M. Drzewiecki, John K.-J. Li, and Abraham Noordergraaf
External Control of Movements; Dejan B. Popovic´ and Mirjana B. Popovic
The Fast Eye Movement Control System; John Denis Enderle
A Comparative Approach to Analysis and Modeling of Cardiovascular Function; John K.-J. Li, Ying Zhu, and Abraham Noordergraaf
A Biomedical and Biophysical Approach to the Science in Cardiopulmonary Resuscitation; Gerrit J. Noordergraaf, Igor W. F. Paulussen, Alyssa Venema, Gert Jan Scheffer, and Abraham Noordergraaf
Kinematic Modeling of Left Ventricular Diastolic Function; Leonid Shmuylovich, Charles S. Chung, and Sándor J. Kovács
STEM CELL ENGINEERING: AN INTRODUCTION
Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm Differentiation; Céline L. Bauwens, Kelly A. Purpura, and Peter W. Zandstra
Cell Mechanobiology in Regenerative Medicine: Lessons from Cancer; Badriprasad Ananthanarayanan and Sanjay Kumar
Systems-Engineering Principles in Signal Transduction and Cell-Fate Choice; Karin J. Jensen, Anjun K. Bose, and Kevin A. Janes
Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation; Stephanie Willerth and David Schaffer
Stem Cells and Regenerative Medicine in the Nervous System; Shelly Sakiyama-Elbert
Stem Cells and Regenerative Medicine for Treating Damaged Myocardium; Rohini Gupta, Kunal Mehtani, Kimberly R. Kam, and Kevin E. Healy
Stem Cells and Hematopoiesis; Krista M. Fridley and Krishnendu Roy
Synthetic Biomaterials and Stem Cells for Connective Tissue Engineering; Ameya Phadke and Shyni Varghese
Derivation and Expansion of Human Pluripotent Stem Cells; Sean P. Palecek
Bioreactors for Stem Cell Expansion and Differentiation; Carlos A. V. Rodrigues, Tiago G. Fernandes, Maria Margarida Diogo, Cláudia Lobato da Silva, and Joaquim M. S. Cabral
TISSUE ENGINEERING
Strategic Directions; Peter C. Johnson
Silks; Monica A. Serban and David L. Kaplan
Calcium Phosphates; Kemal Sariibrahimoglu, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, and John A. Jansen
Engineered Protein Biomaterials; Andreina Parisi-Amon and Sarah C. Heilshorn
Synthetic Biomaterials; Joshua S. Katz and Jason A. Burdick
Growth Factors and Morphogens: Signals for Tissue Engineering; A. Hari Reddi
Signal Expression in Engineered Tissues; Martha O. Wang and John P. Fisher
Pluripotent Stem Cells; Todd C. McDevitt and Melissa A. Kinney
Hematopoietic Stem Cells; Ian M. Kaplan, Sebastien Morisot, and Curt I. Civin
Mesenchymal Stem Cells; Pamela C. Yelick and Weibo Zhang
Nanobiomaterials for Tissue Engineering; Pramod K. Avti, Sunny C. Patel, Pushpinder Uppal, Grace O’Malley, Joseph Garlow, and Balaji Sitharaman
Biomimetic Approaches in Tissue Engineering; Indong Jun, Min Sup Kim, Ji-Hye Lee, Young Min Shin, and Heungsoo Shin
Molecular Biology Techniques; X.G. Chen, Y.L. Fang, and W.T. Godbey
Biomaterial Mechanics; Kimberly M. Stroka, Leann L. Norman, and Helim Aranda-Espinoza
Mechanical Conditioning; Elaine L. Lee and Horst A. von Recum
Micropatterned Biomaterials for Cell and Tissue Engineering; Murugan Ramalingam and Ali Khademhosseini
Drug Delivery; Prinda Wanakule and Krishnendu Roy
Gene Therapy; C. Holladay, M. Kulkarni, W. Minor, and Abhay Pandit
Nanotechnology-Based Cell Engineering Strategies for Tissue Engineering and Regenerative Medicine Applications; Joaquim Miguel Oliveira, João Filipe Mano, and Rui Luís Reis
Cell Encapsulation; Stephanie J. Bryant
Coculture Systems for Mesenchymal Stem Cells; Song P. Seto and Johnna S. Temenoff
Tissue Engineering Bioreactors; Sarindr Bhumiratana, Elisa Cimetta, Nina Tandon, Warren Grayson, Milica Radisic, and Gordana Vunjak-Novakovic
Shear Forces; Jose F. Alvarez-Barreto, Samuel B. VanGordon, Brandon W. Engebretson, and Vasillios I. Sikavitsas
Vascularization of Engineered Tissues; Monica L. Moya and Eric M. Brey
Biomedical Imaging of Engineered Tissues; Nicholas E. Simpson and Athanassios Sambanis
Multiscale Modeling of In Vitro Tissue Cultivation; Kyriacos Zygourakis
Bone Engineering; Lucas A. Kinard, Antonios G. Mikos, and F. Kurtis Kasper
Dental and Craniofacial Bioengineering; Hemin Nie and Jeremy J. Mao
Tendon and Ligament Engineering; Nicholas Sears, Tyler Touchet, Hugh Benhardt, and Elizabeth Cosgriff-Hernández
Cartilage Tissue Engineering; Emily E. Coates and John P. Fisher
TMJ Engineering; Michael S. Detamore
Interface Tissue Engineering; Helen H. Lu, Nora Khanarian, Kristen Moffat, and Siddarth Subramony
The Bioengineering of Dental Tissues; Rena N. D’Souza, Katherine R. Regan, Kerstin M. Galler, and Songtao Shi
Tissue Engineering of the Urogenital System; In Kap Ko, Anthony Atala, and James J. Yoo
Vascular Tissue Engineering; Laura J. Suggs
Neural Engineering; Yen-Chih Lin and Kacey G. Marra
Tumor Engineering: Applications for Cancer Biology and Drug Development; Joseph A. Ludwig and Emily Burdett
ARTIFICIAL ORGANS
Artificial Heart and Circulatory Assist Devices; Gerson Rosenberg
Cardiac Valve Prostheses; Arjunon, Neelakantan Saikrishnan, and Ajit P. Yoganathan
Artificial Lungs; Keith E. Cook, Timothy M. Maul, and William J. Federspiel
Blood Substitutes; Amy G. Tsai, Pedro Cabrales, and Marcos Intaglietta
Liver Support Systems; Matthew S. Chang and Robert S. Brown
Peritoneal Dialysis Equipment; Carlo Crepaldi, Francesca Katiana Martino, Maria Pia Rodighiero, and Claudio Ronco
Artificial Skin and Dermal Equivalents; Dennis P. Orgill, Raul Cortes, and Ioannis V. Yannas
DRUG DESIGN, DELIVERY SYSTEMS, AND DEVICES
Physiological Barriers to Drug Transport; Fan Yuan
Nucleic Acid Aptamers in Drug Delivery; Mark R. Battig, Jing Zhou, and Yong Wang
Dendrimers for Drug Delivery; Giridhar Thiagarajan and Hamidreza Ghandehari
Noninvasive Targeted Protein and Peptide Drug Delivery; Pradeep K. Karla, Durga K. Paturi, Nanda K. Mandava, Animikh Ray, Sulabh Patel, Ranjana Mitra, and Ashim K. Mitra
Environment-Responsive Hydrogels for Drug Delivery; Byung Kook Lee, Jong-Ryoul Kim, Kinam Park, and Yong Woo Cho
Biodegradable PLGA Scaffolds for Growth Factor Delivery; Yusef Khan and Cato Laurencin
PERSONALIZED MEDICINE
Physiogenomic Contours: The Application of Systems Biology for Engineering Personalized Health Care; Andreas Windemuth, Richard L. Seip, and Gualberto Ruaño
The Evolution of Massively Parallel Sequencing Technologies: Facilitating Advances in Personalized Medicine; Ian Toma, Georges St. Laurent, III, Samuel Darko, and Timothy A. McCaffrey
Computational Methods and Molecular Diagnostics in Personalized Medicine; Roland Valdes, Jr. and Mark W. Linder
Need for Point-of-Care Testing Devices for Cardiac Troponin in Patients with Acute Coronary Syndromes; Alan H.B. Wu and Amy E. Herr
ETHICS
An Introduction to Bioethics and Ethical Theory for Biomedical Engineers; D. John Doyle
Biography
Joseph D. Bronzino is the founder and president of the Biomedical Engineering Alliance and Consortium (BEACON) in Hartford, Connecticut. He earned a PhD in electrical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Bronzino has received the Millennium Award from IEEE/EMBS and the Goddard Award from Worcester Polytechnic Institute for Professional Achievement. He is the author of more than 200 articles and 11 books.
Donald R. Peterson is a professor of engineering and dean of the College of Science, Technology, Engineering, Mathematics, and Nursing at Texas A&M University–Texarkana. He earned a PhD in biomedical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Peterson’s recent research focuses on measuring and modeling human, organ, and/or cell performance, including exposures to various physical stimuli and the subsequent biological responses. Dr. Peterson has published more than 50 journal articles and 12 reference books.
