Molecular, Cellular, and Tissue Engineering  book cover
1st Edition

Molecular, Cellular, and Tissue Engineering

ISBN 9781439825303
Published April 6, 2015 by CRC Press
1892 Pages 461 B/W Illustrations

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Book Description

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.

Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine.

More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.

Table of Contents


Historical Perspective and Basics of Molecular Biology; Nathan R. Domagalski and Michael Domach

Biomolecular Interactions; Gordon Rule

Recent Advances in DNA Separations: Plasmid Purification, Rapid Electrophoresis, and Affinity-Based Recovery; James W. Schneider and Jeffrey M. Savard

Systems and Technology Involving Bacteria; Nicole Bleckwenn and William Bentley

Expression in Mammalian Cells; Tina Sauerwald and Michael Betenbaugh

DNA Vaccines Production and Engineering; Michael M. Domach, Jonathan W. Meade, and Mohammad A. Ataai


Biomimetic Systems: Concepts, Design, and Emulation; Robert J. Fisher

Transport/Reaction Processes in Biology and Medicine; E. N. Lightfoot

Microvascular Heat Transfer; James W. Baish

Fluid Dynamics for Bio Systems: Fundamentals and Model Analysis; Robert A. Peattie and Robert J. Fisher

Animal Surrogate Systems; Michael L. Shuler, Sarina G. Harris, Xinran Li, and Mandy B. Esch

Arterial Wall Mass Transport: The Possible Role of Blood Phase Resistance in the Localization of Arterial Disease; John M. Tarbell and Yuchen Qiu

Transport Phenomena and the Microenvironment; Robert J. Fisher and Robert A. Peattie

Transport and Drug Delivery through the Blood–Brain Barrier and Cerebrospinal Fluid; Bingmei M. Fu

Interstitial Transport in the Brain: Principles for Local Drug Delivery; W. Mark Saltzman

Surfactant Transport and Fluid–Structure Interactions during Pulmonary Airway Reopening; David Martin, Anne-Marie Jacob, and Donald P. Gaver III


Modeling Strategies and Cardiovascular Dynamics; Joseph L. Palladino, Gary M. Drzewiecki, and Abraham Noordergraaf

Compartmental Models of Physiological Systems; Claudio Cobelli, Giovanni Sparacino, Maria Pia Saccomani, Gianna Maria Toffolo, and Andrea Caumo

Cardiovascular Models and Control; Madhusudan Natarajan, Fernando Casas, and W.D. Timmons

Respiratory Models and Control; Chi-Sang Poon

Biomimetic Approaches to Physiological Control; James J. Abbas and Amit Abraham

Methods and Tools for Identification of Physiologic Systems; Vasilis Z. Marmarelis

Modeling Vascular Vibrations: Autoregulation and Vascular Sounds; Gary M. Drzewiecki, John K.-J. Li, and Abraham Noordergraaf

External Control of Movements; Dejan B. Popovic´ and Mirjana B. Popovic

The Fast Eye Movement Control System; John Denis Enderle

A Comparative Approach to Analysis and Modeling of Cardiovascular Function; John K.-J. Li, Ying Zhu, and Abraham Noordergraaf

A Biomedical and Biophysical Approach to the Science in Cardiopulmonary Resuscitation; Gerrit J. Noordergraaf, Igor W. F. Paulussen, Alyssa Venema, Gert Jan Scheffer, and Abraham Noordergraaf

Kinematic Modeling of Left Ventricular Diastolic Function; Leonid Shmuylovich, Charles S. Chung, and Sándor J. Kovács


Engineering the Pluripotent Stem Cell Niche for Directed Mesoderm Differentiation; Céline L. Bauwens, Kelly A. Purpura, and Peter W. Zandstra

Cell Mechanobiology in Regenerative Medicine: Lessons from Cancer; Badriprasad Ananthanarayanan and Sanjay Kumar

Systems-Engineering Principles in Signal Transduction and Cell-Fate Choice; Karin J. Jensen, Anjun K. Bose, and Kevin A. Janes

Biomaterial Scaffolds for Human Embryonic Stem Cell Culture and Differentiation; Stephanie Willerth and David Schaffer

Stem Cells and Regenerative Medicine in the Nervous System; Shelly Sakiyama-Elbert

Stem Cells and Regenerative Medicine for Treating Damaged Myocardium; Rohini Gupta, Kunal Mehtani, Kimberly R. Kam, and Kevin E. Healy

Stem Cells and Hematopoiesis; Krista M. Fridley and Krishnendu Roy

Synthetic Biomaterials and Stem Cells for Connective Tissue Engineering; Ameya Phadke and Shyni Varghese

Derivation and Expansion of Human Pluripotent Stem Cells; Sean P. Palecek

Bioreactors for Stem Cell Expansion and Differentiation; Carlos A. V. Rodrigues, Tiago G. Fernandes, Maria Margarida Diogo, Cláudia Lobato da Silva, and Joaquim M. S. Cabral


Strategic Directions; Peter C. Johnson

Silks; Monica A. Serban and David L. Kaplan

Calcium Phosphates; Kemal Sariibrahimoglu, Joop G.C. Wolke, Sander C.G. Leeuwenburgh, and John A. Jansen

Engineered Protein Biomaterials; Andreina Parisi-Amon and Sarah C. Heilshorn

Synthetic Biomaterials; Joshua S. Katz and Jason A. Burdick

Growth Factors and Morphogens: Signals for Tissue Engineering; A. Hari Reddi

Signal Expression in Engineered Tissues; Martha O. Wang and John P. Fisher

Pluripotent Stem Cells; Todd C. McDevitt and Melissa A. Kinney

Hematopoietic Stem Cells; Ian M. Kaplan, Sebastien Morisot, and Curt I. Civin

Mesenchymal Stem Cells; Pamela C. Yelick and Weibo Zhang

Nanobiomaterials for Tissue Engineering; Pramod K. Avti, Sunny C. Patel, Pushpinder Uppal, Grace O’Malley, Joseph Garlow, and Balaji Sitharaman

Biomimetic Approaches in Tissue Engineering; Indong Jun, Min Sup Kim, Ji-Hye Lee, Young Min Shin, and Heungsoo Shin

Molecular Biology Techniques; X.G. Chen, Y.L. Fang, and W.T. Godbey

Biomaterial Mechanics; Kimberly M. Stroka, Leann L. Norman, and Helim Aranda-Espinoza

Mechanical Conditioning; Elaine L. Lee and Horst A. von Recum

Micropatterned Biomaterials for Cell and Tissue Engineering; Murugan Ramalingam and Ali Khademhosseini

Drug Delivery; Prinda Wanakule and Krishnendu Roy

Gene Therapy; C. Holladay, M. Kulkarni, W. Minor, and Abhay Pandit

Nanotechnology-Based Cell Engineering Strategies for Tissue Engineering and Regenerative Medicine Applications; Joaquim Miguel Oliveira, João Filipe Mano, and Rui Luís Reis

Cell Encapsulation; Stephanie J. Bryant

Coculture Systems for Mesenchymal Stem Cells; Song P. Seto and Johnna S. Temenoff

Tissue Engineering Bioreactors; Sarindr Bhumiratana, Elisa Cimetta, Nina Tandon, Warren Grayson, Milica Radisic, and Gordana Vunjak-Novakovic

Shear Forces; Jose F. Alvarez-Barreto, Samuel B. VanGordon, Brandon W. Engebretson, and Vasillios I. Sikavitsas

Vascularization of Engineered Tissues; Monica L. Moya and Eric M. Brey

Biomedical Imaging of Engineered Tissues; Nicholas E. Simpson and Athanassios Sambanis

Multiscale Modeling of In Vitro Tissue Cultivation; Kyriacos Zygourakis

Bone Engineering; Lucas A. Kinard, Antonios G. Mikos, and F. Kurtis Kasper

Dental and Craniofacial Bioengineering; Hemin Nie and Jeremy J. Mao

Tendon and Ligament Engineering; Nicholas Sears, Tyler Touchet, Hugh Benhardt, and Elizabeth Cosgriff-Hernández

Cartilage Tissue Engineering; Emily E. Coates and John P. Fisher

TMJ Engineering; Michael S. Detamore

Interface Tissue Engineering; Helen H. Lu, Nora Khanarian, Kristen Moffat, and Siddarth Subramony

The Bioengineering of Dental Tissues; Rena N. D’Souza, Katherine R. Regan, Kerstin M. Galler, and Songtao Shi

Tissue Engineering of the Urogenital System; In Kap Ko, Anthony Atala, and James J. Yoo

Vascular Tissue Engineering; Laura J. Suggs

Neural Engineering; Yen-Chih Lin and Kacey G. Marra

Tumor Engineering: Applications for Cancer Biology and Drug Development; Joseph A. Ludwig and Emily Burdett


Artificial Heart and Circulatory Assist Devices; Gerson Rosenberg

Cardiac Valve Prostheses; Arjunon, Neelakantan Saikrishnan, and Ajit P. Yoganathan

Artificial Lungs; Keith E. Cook, Timothy M. Maul, and William J. Federspiel

Blood Substitutes; Amy G. Tsai, Pedro Cabrales, and Marcos Intaglietta

Liver Support Systems; Matthew S. Chang and Robert S. Brown

Peritoneal Dialysis Equipment; Carlo Crepaldi, Francesca Katiana Martino, Maria Pia Rodighiero, and Claudio Ronco

Artificial Skin and Dermal Equivalents; Dennis P. Orgill, Raul Cortes, and Ioannis V. Yannas


Physiological Barriers to Drug Transport; Fan Yuan

Nucleic Acid Aptamers in Drug Delivery; Mark R. Battig, Jing Zhou, and Yong Wang

Dendrimers for Drug Delivery; Giridhar Thiagarajan and Hamidreza Ghandehari

Noninvasive Targeted Protein and Peptide Drug Delivery; Pradeep K. Karla, Durga K. Paturi, Nanda K. Mandava, Animikh Ray, Sulabh Patel, Ranjana Mitra, and Ashim K. Mitra

Environment-Responsive Hydrogels for Drug Delivery; Byung Kook Lee, Jong-Ryoul Kim, Kinam Park, and Yong Woo Cho

Biodegradable PLGA Scaffolds for Growth Factor Delivery; Yusef Khan and Cato Laurencin


Physiogenomic Contours: The Application of Systems Biology for Engineering Personalized Health Care; Andreas Windemuth, Richard L. Seip, and Gualberto Ruaño

The Evolution of Massively Parallel Sequencing Technologies: Facilitating Advances in Personalized Medicine; Ian Toma, Georges St. Laurent, III, Samuel Darko, and Timothy A. McCaffrey

Computational Methods and Molecular Diagnostics in Personalized Medicine; Roland Valdes, Jr. and Mark W. Linder

Need for Point-of-Care Testing Devices for Cardiac Troponin in Patients with Acute Coronary Syndromes; Alan H.B. Wu and Amy E. Herr


An Introduction to Bioethics and Ethical Theory for Biomedical Engineers; D. John Doyle

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Joseph D. Bronzino is the founder and president of the Biomedical Engineering Alliance and Consortium (BEACON) in Hartford, Connecticut. He earned a PhD in electrical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Bronzino has received the Millennium Award from IEEE/EMBS and the Goddard Award from Worcester Polytechnic Institute for Professional Achievement. He is the author of more than 200 articles and 11 books.

Donald R. Peterson is a professor of engineering and dean of the College of Science, Technology, Engineering, Mathematics, and Nursing at Texas A&M University–Texarkana. He earned a PhD in biomedical engineering from Worcester Polytechnic Institute in Massachusetts. Dr. Peterson’s recent research focuses on measuring and modeling human, organ, and/or cell performance, including exposures to various physical stimuli and the subsequent biological responses. Dr. Peterson has published more than 50 journal articles and 12 reference books.