One of the most intriguing discoveries in molecular biology in the last decade is the existence of an evolutionary conserved and essential system, consisting of molecular chaperones and folding catalysts, which promotes the folding of the proteins in the cell. This text summarizes our current knowledge of the cellular roles, the regulation and the mechanism of action of this system. It has a broad scope, covering cell biological, genetic and biochemical aspects of protein folding in cells from bacteria to man.
Particularly appropriate to researchers working in basic and applied aspects of molecular medicine, this volume should also prove useful as an up-to-date reference book and as a textbook for specialized university courses.
1. Assisted Protein Folding 2. Autoregulation of the Heat Shock Response in Procaryotes 3. Protein Kinase Cascades Involved in Heat Shock Protein Expression and Function 4. Genetic Evidence for the Roles of Molecular Chaperones in Escherichia coli Metabolism 5. Functions in Development 6. Early Events in the Synthesis and Maturation of Polypeptides 7. The Role of Molecular Chaperones in Transport and Folding of Mitochondrial Proteins 8. Protein Import into and Folding Within Chloroplasts 9. Control of Hormone Receptor Function by Molecular Chaperones and Folding Catalysts 10. The Role of Hsp104 in Stress Tolerance and Prion Maintenance 11.
Spontaneous Versus Assisted Protein Folding 12. Protein Disulphide-Isomerase: A Catalyst of Thiol: Disulphide Interchange and Associated Protein Folding 13. The Relationship Between Chaperones Structure and Function
14. Structure and Mechanism of Hsp70 Proteins 15. Mechanisms of ATP Independent vs. ATP-Dependent Chaperones 16. Structure and Function of Periplasmic PapD-like Chaperones Involved in Assembly of Bacterial P. Pili