1st Edition

Molecular Genetics & Gene Therapy of Cardiovascular Diseases



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ISBN 9780824794088
Published January 2, 1996 by CRC Press
616 Pages

 
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Book Description

Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nearly 50 investigators on the cutting-edge of pioneering research in the field.

Table of Contents

Molecular Genetics and Its Application to Understanding Cardiovascular Disease

Identifying Genes in Humans

A Nonmathematical Overview of Modern Gene Mapping Techniques Applied to Human Diseases

Molecular Genetics of Human Hypertension

Arrythmias and Vascular Disease

Molecular Genetic Studies of Inherited Cardiomyopathies

Hyperlipidemia: Molecular Defects of Apolipoproteins B and E Responsible for Elevated Blood Lipids

Genetic Causes of Aortic Aneurysms

Marfan Syndrome

Genetic Risk Factors for Myocardial Infarction


Using Animals to Dissect Complex Traits

Using Animal Models to Dissect the Genetics of Complex Traits

Genetic Dissection of Hypertension in Experimental Animal Models

Hypertension Research with Genetically Altered Animals

Genetically Altered Mouse Models of Lipoprotein Disorders and Atherosclerosis

Homologous Recombination and Growth Factors

Gene Targeting of Adhesion Molecules in the Vasculature

Cardiogenesis and Molecular Physiology


Gene Transfer and Therapy

Gene Therapy for Cardiovascular Disease: An Introduction

Gene-Transfer Approaches to Vascular Disease

Gene Transfer Approaches to Myocardial Diseases

Gene Therapy Approaches to Metabolic and Cardiovascular Disorders

Vascular Smooth Muscle Cell Proliferation: Basic Investigations and New Therapeutic Approaches

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Reviews

"
…gets you up to speed on this rapidly expanding area of research.
"-Bulletin of the British Society for Cardiovascular Research