Authoritative and insightful, this important text provides an update on the latest advances in the areas of biomedical research that are at the interface of science and clinical medicine, where new discoveries in genetics, molecular and cell biology are not only enhancing our understanding of the etiology and progression of disease but are finding application in the development of new drugs or the implementation of new kinds of therapy. Reviewing current knowledge of the mechanisms contributing to hypertension, an internationally renowned team of contributors highlights developments across a broad range of disciplines and provides an overview of the advances in biomedical research that have a direct bearing on current clinical studies. A key work in its field, this text will have broad appeal to clinical cardiologists, vascular medicine specialists, and internists, as well as members of the cardiovascular research community and pharmaceutical and biotechnology industries.
Table of Contents
Part I: Renin / Angiotnsin /Aldosterone Systems. Biology of AII (Synthesis, Degradation, Measurement, Fragments and A1-7, AIV, ACE2, Inflammation, Coagulation, Angiogenesis). Actions of AII. Actions of Aldsterone. Biology of Renin/Prorenin/Renin Exon 1A/Direct Renin Action, Renin Synthesis. Circulating RAAS. Tissue RAASs Part II: Renal Mechanisms in Hypertension. Pressure Naturesis. Intraglomerular Pressure and Nephron Loss . Nephron Number and BP. Renal Prostaglandins/Depressors and BP. Role of Dopamine. Modulator and Non-Modulator Hypertension. TGF and BP. Renal Causes of Secondary Hypertension. ACE Inhibitor Prevention of Hypertension. Other Mechanisms Part III: Endocrine Hypertension. Adrenocortical Hypertension. Adrenergic Nervous System. Pheochromocytoma. Other Endocrine Causes of Hypertension Part IV: Non-Ras Peptides. Vasopressin and Neuropeptide Y, Calcitonin GRP, Leptin. Natriuretic Factors. Endothelin. Kinins/ACE Substrates Part V: Secondary Messengers and the Sequelae of Hypertension. Signal Transduction. Regulation of Blood Flow (incl TGF). Vascular Distensability, Pulse Pressure, and Vascular Pathology. Myogenic Regulation and BP. Regression of Vascular Hypertrophy. Left Ventricular Hypertrophy Onset/Regression/Remodeling/Fibrosis. Nitric Oxide/Oxidative Stress/Endothelial (Dys)Function. Prostaglandins, Lypoxigenase Products and BP Control. Endogenous Na/K ATPase Inhibitors Part VI: Genomics, Proteomics and Hypertension. Gene Regulation, Hypertension, Hypertensive Sequelae. Genomic Microarrays and Hypertension. Transgenic and Knock-Out Models of Hypertension. Application of Antisense and Sirna to the Study of Hypertension. Heritable Monogenic Forms of Hypertension (Liddle's etc, Laidlaw's etc) 39. Genetics of Hypertension. Gene Therapy and Hypertension. Proteomics and Hypertension. The Proteosome and the Development of Hypertensive Sequelae. Apoptosis and the Sequelae of Hypertension 44. Stem Cells and Cardiovascular Structure Part VII: Other Issues. Sodium and Potassium in Hypertension. Divalent Cations/ Hypertension. Birthweight and Hypertension. Baroreflexes
"Molecular Mechanisms is noteworthy not only because of its scope and organization, but also because it seeks to unlock the mechanisms of cause behind a disease that has confounded physicians for generations."
"This text throws down the gauntlet and compels physicians to not simply be content with prescribing the medications currently available, but instead to look to locate the catalyst behind the breakdown in hopes that a better understanding of the disease will inspire more efficient medical therapies (and eventual prevention)."
"Recommended as a reference manual for researchers in cardiology and vascular medicine - the new information presented by Re and co-writers is meant to bring medicine back to the drawing board insofar as hypertension is concerned"
John Aiello, (Electronic Review, Jan 07)