This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.
MECHANISMS FOR CARDIAC HYPERTROPHY. Mechanisms for Normal CV Growth and Development. Cell Cycle Control. Apoptosis. G-Protein Coupled Receptors. Mechanotransduction. Extracellular Matrix. Physiologic vs. Pathologic Hypertrophy. Abnormal Signal Transduction. Tissue Regeneration. MECHANISMS FOR CONTRACTILE DEPRESSION. Normal Excitation Contraction Coupling and Calcium Homeostasis. Calcium Homeostasis. Myocardial Ischemia and Infarction. Cardiac Remodeling. Inflammation. Phosphorylation/Dephosphorylation. Cytoskeleton. Environmental Factors in Cardiac Hypertrophy and Failure. ELECTRICAL PROPERTIES. Normal Action Potential Generation Propagation and Repolarization. Depolarization Abnormalities. Repolarization Abnormalities. Cell-Cell Transmission Abnormalities. GENETIC BASIS FOR CARDIOMYOPATHY. Genomic Analysis. Monogenetic Abnormalities. Polygenic Abnormalities and the Roles of Transcriptional Profiling and Proteomics.