Molecular Targets and Therapeutic Interventions against Neurodegenerative Diseases

Preface 

1. Comprehensive Review on Alzheimer’s Disease: Recent Approaches and Treatment Strategies

Nandini H. S., Prashant Tiwari, and Erwin Faller

2. Novel Molecular Targets at the Forefront of Neurodegenerative Research

Madhu Tanya Singh and Praveen Thaggikuppe Krishnamurthy

3. Potential Novel Targets for Alzheimer Pharmacotherapy: Update on JNK3, GSK3β, and Fyn Kinase Inhibitors and Related Approaches

Mariya Jahangir and Mymoona Akhter

4. The TREM2 Receptor Puzzle in Alzheimer's Disease: Assembling the Pieces

Gadde Shareena, Dileep Kumar, and Satheesh Kumar Sellamuthu

5. Phosphodiesterase: A Safe and Potential Target for Anti-Alzheimer’s Therapeutics

Shikha Kaushik, Sarvesh Paliwal, Neeraj Masand, and Vaishali Manikrao Patil

6. The NMDA Receptor Hypothesis in Alzheimer's Disease: Unraveling the Mechanisms

Gadde Shareena, Dileep Kumar, and Satheesh Kumar Sellamuthu

7. Artificial Intelligence and Machine Learning-Based Advances in the Management of Neurodegenerative Diseases

Ankita Wal, Mangla Nand Singh, Himangi Vig, Manoj Kumar Katul, Bommaiah Prakash Kumar, and Manukonda Upender Kumar

8. Microglia, a New Avenue in the Cure and Treatment of Alzheimer’s Disease

Dipanjan Karati and Dileep Kumar

9. Neuropharmacological Mechanisms of SARS-CoV-2

Swati Kaushik, Manisha Singh, Sonika Srivastava, Anupam K. Sachan, and Saroj Verma

10. Current Perspectives on Pyrazole Scaffolds and Their Potential Impact on Alzheimer's Disease

Akshay Kumar, Pragya Gawande, Souranava Jana, Anjali Murmu, Balaji Wamanrao Matore, Jagadish Singh, and Partha Pratim Roy

11. Role and Therapeutic Perspectives of Oxidative Stress in Neurodegenerative Diseases

Rakhi Mishra, Prem Shankar Mishra, Vaishali Manikrao Patil, and Preeti Kumari

12. Herbs and Natural Products for Neurodegenerative Disorders

Rashmi Saxena Pal, Sharma Vedika Vijaypal, Yogendra Pal, MVNL Chaitanya, Priyanka, and Deepti Katiyar

13. Role of Nanotechnology in Multiple Sclerosis

Anjana Sharma and Nitin Sharma

14. Therapeutic Advancement in the Treatment of Neurodegenerative Diseases

Praveen Kumar Gaur, Rosaline Mishra, Raju Singh, Moumita Barman, and Kanak Lata

15. Recent Developments in Nanotechnology-Based Therapeutics for the Treatment of Alzheimer’s Disease

Harsh Yadav, Shubhas P, Satish Dubey, Anand Maurya, Ramu Singh, and Sabyasachi Maiti

Index

Biography

Vaishali Manikaro Patil holds the position of Principal/Head at Charak School of Pharmacy, Chaudhary Charan Singh University in Meerut, India, and also serves as a Visiting Professor at the Faculty of Pharmaceutical Sciences, UCSI University in Kuala Lumpur, Malaysia. With over 17 years of academic and 3 years of industrial experience, her primary research lies in medicinal chemistry and computer-aided drug design, focusing on quantitative structure–activity relationship studies, drug-receptor interactions, and the synthesis of small heterocyclic molecules. Dr Patil, a recipient of prestigious awards, has authored numerous research papers, books, and book chapters, contributing globally through lectures and participation in scientific communities including the World Health Organization, American Chemical Society, and APTI-India.

Dileep Kumar, holding degrees from Manipal University and S.G.S.I.T.S Indore, serves as an Assistant Professor at Poona College of Pharmacy and also has a visiting faculty position at the University of California, Davis. With research interests in the design of GluN2B selective NMDA receptor antagonists and amyloid-β protein aggregation inhibitors for Alzheimer's disease treatment, Dr Kumar actively contributes to cancer research at UC Davis Comprehensive Cancer Center.

Neeraj Masand, Assistant Professor at Lala Lajpat Rai Memorial Medical College in Meerut, earned degrees from North Maharashtra University and Dr. A. P. J. Abdul Kalam Technical University, Lucknow. With over 16 years of academic and research experience, his current research focuses on designing gamma-secretase inhibitors for Alzheimer's disease treatment and synthesizing novel heterocyclic analogues. Dr Masand has authored numerous research papers, books, and book chapters.