The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology, chemistry, physics, image analysis, and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools.
Bringing together a select panel of internationally recognized authors, Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information, the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive, in vivo studies. The first section examines the physicochemical principles of various contrast agents including paramagnetic, superparamagnetic, CEST, and PARACEST agents, as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer, apoptosis, cardiovascular and neurodegenerative disease, and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications, and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging.
Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic tool.
"The excellent chapter about methods for labeling nonphagocytic cells is noteworthy . . . will be valuable for researchers in the field of molecular imaging to recess their knowledge or use as a reference book."
– Fabian Kiessling, Department of Medical Physics in Radiology, Juniorgroup Molecular Imaging, German Cancer Research Center, in International Journal of Radiation Oncology Biology & Physics, 2007 Vol. 69, No. 4
What Is Molecular and Cellular Imaging?, M.M. Modo and J.W.M. Bulte
Contrast Agents for Molecular and Cellular Imaging
Physicochemical Principles of MR Contrast Agents, P. Caravan
Paramagnetic Contrast Agents, S. Aime, Z. Baranyai, E. Gianolio, and E. Terreno
Superparamagnetic Contrast Agents, C. Corot, M. Port, I. Guilbert, P. Robert, I. Raynal,
C. Robic, J.S. Raynaud, P. Prigent, A. Dencausse, and J.M. Idée
Physical Mechanism and Applications of CEST Contrast Agents, M.T. McMahon, J. Zhou, A.A. Gilad, and P.C.M. van Zijl
PARACEST Contrast Agents, A.D. Sherry and M. Woods
Genetic Approaches for Modulating MRI Contrast, E. T. Ahrens, W. F. Goins, and C.S. Robison
Molecular MR Imaging
Molecular and Functional MR Imaging of Cancer, M. A. Jacobs, K. Glunde, B. Gimi, A. P. Pathak,
E. Ackerstaff, D.Artemov, and Z. M. Bhujwalla
Molecular Imaging of Atherosclerosis with Magnetic Resonance, K. C. Briley-Saebo, W.J. Mulder, F. Hyafil, V. Mani, V. Amirbekian, J. Gilberto, S. Aguinaldo, J. F. Rudd, S. H. Aguiar, and Z.A. Fayad
Molecular Imaging of Apoptosis, M. I. Kettunen and K. M. Brindle
Molecular Imaging of Reporter Genes, K. Ziv, D. Granot, V. Plaks, B. Cohen, and M. Neeman
Pharmacological MRI as a Molecular Imaging Technique, Y. I. Chen and B. G. Jenkins
Cellular MR Imaging
Cellular MR Imaging of the Liver Using Contrast Agents, N. C. Balci and S. Mehmet Erturk
Cellular Imaging of Macrophage Activity in Infection and Inflammation, M. Rausch, M. Rudin, P. Allegrini, and N. Beckmann
Cellular Imaging of Macrophage Activity in Stroke, R. Weber and M. Hoehn
Magnetic Resonance Imaging in Developmental Biology, C. Papan, J. M. Tyszka, and R. E. Jacobs
Methods for Labeling Non-phagocytic Cells with MR Contrast Agents, J.A. Frank, S. A. Anderson, and A. S. Arbab
Cellular Imaging of Cell Transplants, M.M.J.J. Modo and J.W.M. Bulte
Cellular and Molecular Imaging of the Diabetic Pancreas, Z. Medarova and A. Moore
Functional Cellular Imaging with Manganese, V. Van Meir and A. Van der Linden
Future Perspectives for Molecular and Cellular Imaging
Translating Promising Experimental Approaches to Clinical Trials, A. D. Nunn
An Outlook on Molecular and Cellular MR Imaging, M. Modo and J. W.M. Bulte