1st Edition

Monographs in Contact Allergy, Volume 1 Non-Fragrance Allergens in Cosmetics (Part 1 and Part 2)

    1468 Pages 399 B/W Illustrations
    by CRC Press

    1472 Pages 399 B/W Illustrations
    by CRC Press

    Monographs in Contact Allergy, Volume 1: Non-Fragrance Allergens in Cosmetics (Part 1 and Part 2) is the first 2-part volume in an exciting series on contact allergy.

    It presents over 500 natural or synthetic chemicals and compounds which have caused allergic contact dermatitis in cosmetic products. Included here are INCI names, synonyms, description/definition, CAS and EU numbers, chemical class, function in cosmetics, molecular formula, structural formula and advice on patch tests. A full literature review is given of patch testing in patients, case reports of cosmetic allergic contact dermatitis, irritant contact dermatitis, photosensitivity, immediate contact reactions and systemic side effects.

    This text is suitable for anyone with an interest in contact allergy, from university students to professionals, and all readers will find this informative and detailed series an invaluable resource.

    Key Features:

  • Monographs of all known non-fragrance chemicals and substances which have caused allergic contact dermatitis from their presence in cosmetic products
  • Provides lists of all functional groups (such as antioxidants, preservatives, artificial nail building, emollients, hair dyeing, hair colorants) in both the EU and US formats and all chemicals in these groups which have caused cosmetic allergy
  • Presents an alphabetical list of all synonyms indicating their INCI names
  • Reported cross-reactions, pseudo-cross-reactions and co-reactions, patch test sensitization and presence in cosmetic products (including data from FDA’s Voluntary Cosmetic Registration Program) and chemical analyses are discussed
  • Covers an extensive amount of information to benefit dermatologists, allergists, and non-medical professionals involved with the research, development and marketing of cosmetic products
  • Preface.


    About the author.

    PART 1

    Chapter 1: Introduction.

    Chapter 2: Monographs of chemicals and substances in cosmetics that have caused allergic contact dermatitis.

    PART 2

    Chapter 2 (Ctd.): Monographs of chemicals and substances in cosmetics that have caused allergic contact dermatitis.

    Chapter 3: Monographs of chemicals and substances in cosmetics that have caused immediate-type reactions.

    Chapter 4: Monographs of chemicals and substances in cosmetics that have caused photosensitivity.

    Chapter 5: Functional classes and chemicals/substances in these classes that have caused allergic cosmetic dermatitis.

    Chapter 6: List of synonyms.



    1980-2002 dermatologist in private practice in two hospitals in ‘s-Hertogenbosch, The Netherlands. PhD 1988: Adverse Reactions to Cosmetics. Author of over 500 publications including 70 book chapters and 14 books, of which 4 are international (mainly for dermatologists) and 10 in Dutch for general practitioners, medical students, skin therapists, podiatrists/pedicures and (parents of) patients with atopic dermatitis. Regularly teaches dermatology to medical students at the University of Groningen. Member of the Editorial Board of the journal Dermatitis (specialized in contact allergy). Co-founder and former 10-year Editor-in-Chief of the Dutch Journal for Dermatology and Venereology.

    Anton C. De Groot is an honourary member of the American Contact Dermatitis Society, he was specifically recognised for his contributions to the field through his series Monographs in Contact Allergy

    Further information can be found on the author's website www.patchtesting.info

    'Anton de Groot has outdone himself!

    In Monographs in Contact Allergy, he has provided a 2 volume-catalog of close to 500 non-fragrance chemicals in cosmetics that span the common and the rare.

    This authoritative compendium will be a useful resource for those of us -- academicians, practitioners, industry professionals -- who manage, study, and think about individuals with contact dermatitis.'

    Ponciano D. Cruz, Jr., MD, Editor-in-Chief, Dermatitis


    ‘This two-part 1430 pages book written by Anton de Groot presents 500 monographs on chemicals and substances that have caused contact allergy / allergic contact dermatitis by their presence in cosmetics. Each monograph begins with the section "Identification": name, description/definition, chemical class, IUPAC name, other names, CIR and SCCS data, functions in cosmetics, patch testing advice, chemical formula and (beautifully drawn) structural formulas. In each monograph, data are provided (if such information is available) on results of patch testing in unselected patients suspected of contact dermatitis (routine testing), testing in selected patient groups (e.g., individuals suspected of cosmetic reactions, patients with leg ulcers, hairdressers, children, patients with periorbital dermatitis), case reports and case series of cosmetic allergy, allergy from non-cosmetic products, cross-reactivity, patch test sensitization, provocation tests, dilution series testing, chemical analyses and frequency of use in cosmetics in the USA (including recent data from FDA’s Voluntary Cosmetic Registration Program). Next, info is provided on irritant contact dermatitis, immediate contact reactions, non-eczematous adverse effects, systemic side effects and other relevant data. In other words, the monographs are not limited to cosmetic allergy but provide full reviews. Many are 1-3 pages only, but some monographs have >10 pages (e.g.,benzophenone-3, chlorhexidine digluconate, imidazolidinyl urea, propylene glycol), >20 (colophonium, formaldehyde, methylisothiazolinone) and even >30 pages (MCI/MI and p-phenylenediamine).

    Because of our special interest in p-phenylenediamine, I have studied this monograph carefully and it proved to give a clear, informative, complete, very useful and detailed review of contact allergy and other side effects of p-phenylenediamine in hair dyes and other products with no less than 344 literature references. A nice touch was a bit of history about the French chemist Eugène Schueller, who marketed the product at the beginning of the 20th century with his French Harmless Hair Dye Company, from which L’Oreal developed. Knowing Anton, I am sure he has spent the same amount of energy and accuracy in all other monographs. Following the section with monographs (1325 pages) there are smaller chapters on immediate contact reactions, photosensitivity, a complete list of cosmetic functional groups (preservatives, sunscreens, humectants et cetera) and all chemicals in these groups that have caused cosmetic allergy, followed by a 30-page alphabetical list of synonyms referring to the names used for the monograph titles (INCI names where available).

    After Patch Testing and Essential oils, this is yet another phenomenal reference book from Anton, which will make our work in the patch testing clinic easier and more fruitful and which is also very helpful for authors. I am looking out for the next two volumes in the Monographs series on Fragrances (volume II) and Topical and systemic drugs (Volume III).’

    M.L.A. Schuttelaar, University Medical Center Groningen, Groningen, The Netherlands for the European Society of Contact Dermatitis


    'The 2-volume, 1430-page publication provides a complete overview of the full knowledge of non-"fragrance" cosmetic allergens, and can be recommended for dermatologists and allergologists alike and also specialists indicating, performing and evaluating patch tests as an essential tool like the "Bible" in their practice.'

    Prof. Erzsébet Temesvári, MD, PhD


    ‘I have had the opportunity to review the textbook entitled Monographs in Contact Allergy: Non-Fragrance Allergens in Cosmetics (Parts 1 and 2) published by CRC Press, Boca Raton, FL, 2018, and written by Anton C. de Groot. The author is well known for his textbook Patch Testing.  His latest monograph is an encyclopedic publication that is composed of 2 textbook-sized volumes as a set that describe a total of 497 chemical ingredients that have caused contact allergy or allergic contact dermatitis by their presence in cosmetic product... This monograph is highly recommended and is a comprehensive reference that best serves the needs of dermatologists or allergists involved in the advanced practice of patch testing. It contains concise summaries of each of the 497 chemical ingredients described, is well referenced, and also contains practical information about patch testing concentrations of these chemicals, especially for those ingredients that are less commonly encountered allergens’.

    – Anthony A. Gaspari, MD