1st Edition

Mood Disorders Practical Issues in Diagnosis and Management

By Ather Muneer Copyright 2018
    222 Pages
    by Routledge

    222 Pages
    by Routledge

    Mood Disorders: Practical Issues in Diagnosis and Management provides cutting edge knowledge about the diagnosis and treatment of principal mood disorders, namely major depressive disorder and bipolar disorder. Covering diagnosis, differentiating features, and illness course and trajectories of principal mood disorders, Dr. Ather Muneer provides essential information in a succinct and practical manner, while highlighting significant new findings in the area. This book will help a broad range of mental health professionals better treat the millions of people with mood disorders across the globe.

    Table of Contents

    Chapter 1: Major Depressive Disorder and Bipolar Disorder


    Signs and Symptoms

    Diagnosis of Mood Disorders

    Major Depressive Disorder

    Bipolar Disorder

    Seasonal Affective Disorder (SAD)


    Chapter 2: Major Mood Disorders: Differentiating Features


    Allostatic Load Model of Mood Disorders

    Mood Disorders as Systemic Ailments

    Differentiating Features of Unipolar and Bipolar Depression

    Affective Ailments as Spectrum Disorders

    Psychometric Scales

    How to Differentiate Between Unipolar and Bipolar Depression?

    Catatonic Symptoms of Mood Disorders


    Chapter 3: Cormorbidity in Mood Disorders


    The Relation Between Mood Disorders and Inflammatory Comorbidity

    Mechanisms Linking Immune-Inflammatory Imbalance to GMC in Mood Disorders

    Therapeutic Considerations


    Chapter 4: Etiology- The Role of Epigenetics


    The Relationship Between Mood Disorders and Inflammation

    The Biological Mechanisms Linking Mood Disorders and Inflammation

    Neuronal Plasticity

    Childhood Abuse and Mood Disorders

    The Link Between Childhood Trauma and Inflammation

    Childhood Trauma and Neuronal Plasticity

    The Epigenetic Link

    Future Directions


    Chapter 5: Neurobiology of Mood Disorders- The Circadian Connection


    Mood Disorders and the Circadian System

    The Neurobiology of the Circadian System


    Chapter 6: Pathogenesis of Mood Disorders- The Neuroinflammatory Hypothesis


    Neuroinflammation- The Role of Cytokines

    Inflammation, Kynurenines and Mood Disorders

    Purported Model of Depression

    Oxidative Stress


    Chapter 7: Mood Disorders- Staging and Neuroprogression


    Developmental Trajectory and Clinical Heterogeneity of Mood Disorders

    Neuroprogression as the Basis for Staging Mood Disorders

    Allostatic Load and Neuroprogression

    Biomarkers of Mood Disorders

    Staging Models of BD

    Staging Model for MDD

    Therapeutic Implications of Staging

    Limitations of the Staging Models


    Chapter 8: The Management of Treatment Resistant Depression- Monoamines and Beyond


    Switching or Combining 1st Line Antidepressants for TRD

    Combining Atypical Antipsychotics with Standard Antidepressants

    Voritoxetine in TRD

    Targeting Other Pathways in TRD


    Chapter 9: Treatment of Bipolar Depression- The Current Perspective


    Lithium and Anticonvulsants

    Atypical Antipsychotics


    Chapter 10: Manic Phase of Bipolar Disorder- Treatment Recommendations


    Diagnosis of Mania

    Treatment of Mania

    Maintenance Treatment


    Chapter 11: Mood Disorders- Non-Pharmacological Treatments



    Cognitive Behavioral Therapy

    Interpersonal and Social Rhythm Therapy

    Dialectical Behavior Therapy

    Mindfulness-Based Cognitive Therapy

    Family Therapies

    Future Directions in Research on Psychological Treatments




    Ather Munner, MD, is assistant professor of psychiatry at the Islamic International Medical College, Riphah International University, Islamabad. He has published papers in numerous journals, and is a member of the Pakistan Psychiatric Society and the European Psychiatric Association.