1st Edition

Mood Dysregulation Beyond the Bipolar Spectrum

By Deborah A. Deliyannides Copyright 2024
    308 Pages 14 Color Illustrations
    by Apple Academic Press

    308 Pages 14 Color Illustrations
    by Apple Academic Press

    308 Pages 14 Color Illustrations
    by Apple Academic Press

    Reflecting the author’s vast clinical experience as a psychiatrist, this volume explains why so many people with treatment resistant depression respond to medication used to treat individuals with bipolar disorder. The book also helps to minimize the bipolar stigma by introducing the concept of "mood dysregulation."

    At present, people with mood dysregulation are not adequately described on the pages of any diagnostic manual. A cardinal feature of mood dysregulation is dysphoria, a negative mood that is poorly understood but mistaken for the negative mood of depression, creating diagnostic confusion, one of the sources of treatment resistant depression. The author explains that a preponderance of the people she has seen in her practice who have so-called depression have mood disorders with features of bipolar disorder, including response to medications typically effective in people with bipolar disorders. Thus, these people are research orphans: to this day, a paucity of literature exists on this group of individuals. In this volume, the author addresses the clinical problems that result from failure to recognize such mood disorders.

    Key features of the book:

    • Provides a thorough discussion of dysphoria that is not found in other books on the market
    • Proposes a solution to a common and troublesome clinical problem, that of misidentified treatment resistant depression
    • Helps to destigmatize the treatments that are most beneficial to those with dysphoria by introducing the concept of "mood dysregulation"
    • Discusses the etiology of mood disorders with implications for prevention

    This volume aims to help mental health professionals and patients more accurately recognize negative mood symptoms, dysphoria in particular, and arrive at more appropriate interventions to improve treatment outcomes for depression. No other book on the market takes up the topic of dysphoria and how its confusion with depression can lead to diagnostic mistakes that, in turn, lead to treatment failures and so-called treatment resistant depression.



    DSM-5 Bipolar Disorders

    • Bipolar Disorder
    • Bipolar II Disorder
    • Cyclothymia
    • Bipolar Spectrum
    • "Soft" Bipolar Spectrum
    • Mixed States

    DSM–5 Depressive Disorders

    • Disruptive Mood Dysregulation Disorder
    • Major Depressive Disorder
    • Persistent Depressive Disorder



    • Nomenclature
    • Mood Dysregulation
    • Phenotype
    • Affective Temperaments
    • Beyond the Bipolar Spectrum
    • Dysphoria
    • Emotion vs. Affect vs. Mood


    • Other Specified Bipolar and Related Disorder
    • Unspecified Bipolar and Related Disorder
    • Borderline Personality Disorder
    • Attention–Deficit/Hyperactivity Disorder
    • Eating Disorders
    • Posttraumatic Stress Disorder
    • Generalized Anxiety Disorder
    • Panic Disorder
    • Substance Use Disorders
    • Disruptive Mood Dysregulation Disorder
    • Related Conditions
    • (Some) Treatment Resistant Depression
    • Pseudo-Unipolar Depression
    • Atypical Depression

    6. BIOLOGY

    • Brain
    • The Triune Brain
    • Reptilian Brain
    • Limbic Brain
    • Amygdala
    • Hippocampus
    • Hypothalamus/Pituitary Gland
    • Basal Ganglia
    • Neocortex
    • Peripheral Nervous System
    • Neural Components
    • Communication Systems
    • Hormones
    • Neurotransmitters
    • Biology of Emotion Regulation
    • Brain Regulation
    • Vagal Regulation
    • HPA Regulation


    • Environmental Stress
    • Attachment Theory
    • Epigenetics
    • Chronic Stress Response
    • Neural Effects of Chronic Stress
    • Structural Effects of Chronic Stress
    • Immunologic Effects of Chronic Stress


    • Environmental Treatment
    • Neurofeedback
    • Psychotherapy
    • Medication Treatments
    • Anxiety
    • Benzodiazepine
    • Propranolol
    • Other Medications
    • Depression
    • MAOIs
    • Glutamatergic
    • Other Agents
    • Mood Stabilizers
    • Psychostimulants



    Deborah A. Deliyannides, MD, graduated from Jefferson Medical College, Philadelphia, PA, and completed her psychiatric residency at the New York Hospital-Cornell Medical Center in White Plains, NY. She is Assistant Clinical Professor of Psychiatry at Columbia University College of Physicians and Surgeons, New York, NY, and has been a research psychiatrist at the New York State Psychiatric Institute since 1990, where she treated a vast array of people with mood disorders. She was Medical Director of the Zucker Hillside Hospital Methadone Maintenance Treatment Program at the Long Island Jewish Medical Centre in Glen Oaks, NY, for over 10 years and earned added qualifications in addiction psychiatry. She is currently a psychoanalytic candidate at the NYU Post Doctoral Program for Psychotherapy and Psychoanalysis, and maintains private practices in Manhattan and in Darien, CT.