Mood Dysregulation : Beyond the Bipolar Spectrum book cover
1st Edition

Mood Dysregulation
Beyond the Bipolar Spectrum

  • Available for pre-order. Item will ship after February 15, 2023
ISBN 9781774912447
February 15, 2023 Forthcoming by Apple Academic Press
318 Pages 15 Color Illustrations

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USD $69.95

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Book Description

Reflecting the author’s vast clinical experience as a psychiatrist, this volume explains why so many people with treatment resistant depression respond to medication used to treat individuals with bipolar disorder while helping to minimize the bipolar stigma by introducing the concept of "mood dysregulation."

At present, people with mood dysregulation are not adequately described on the pages of any diagnostic manual. A cardinal feature of mood dysregulation is dysphoria, a negative mood that is poorly understood but mistaken for the negative mood of depression, creating diagnostic confusion, one of the sources of "treatment resistant depression". The author explains that a preponderance of the people she has seen in her practice who have so-called "depression" have mood disorders with features of bipolar disorder, including response to medications typically effective in people with bipolar disorder, but their symptoms are not to be found on the pages of the DSM (which outlines criteria to assemble a research cohort). Thus, these people are research orphans: to this day, a paucity of literature exists on this group of individuals. In this volume, the author addresses the clinical problems that result from failure to recognize such mood disorders.

Key features of Mood Dysregulation: Beyond the Bipolar Spectrum:

  • Mood Dysregulations: Beyond the Bipolar Spectrum
  • Provides a thorough discussion of dysphoria that is not found in other books on the market
  • Proposes a solution to a common and troublesome clinical problem, that of misidentified "treatment resistant depression"
  • Attempts to destigmatize the treatments that are most beneficial to those with dysphoria by introducing the concept of "mood dysregulation"
  • Discusses the etiology of mood disorders with implications for prevention

This volume aims to help mental health professionals and patients more accurately recognize negative mood symptoms, dysphoria in particular, and arrive at more appropriate interventions to improve treatment outcomes for depression. No other book on the market takes up the topic of dysphoria and how its confusion with depression can lead to diagnostic mistakes that, in turn, lead to treatment failures and so-called "treatment resistant depression." If dysphoria was recognized, however, proper treatment could be administered promptly, preventing a series of failed treatments and multiple referrals. This book provides an eye-opening insight to a broad audience as well as to clinical professionals in psychiatry and other mental health fields.

Table of Contents



DSM-5 Bipolar Disorders

  • Bipolar Disorder
  • Bipolar II Disorder
  • Cyclothymia
  • Bipolar Spectrum
  • "Soft" Bipolar Spectrum
  • Mixed States

DSM–5 Depressive Disorders

  • Disruptive Mood Dysregulation Disorder
  • Major Depressive Disorder
  • Persistent Depressive Disorder



  • Nomenclature
  • Mood Dysregulation
  • Phenotype
  • Affective Temperaments
  • Beyond the Bipolar Spectrum
  • Dysphoria
  • Emotion vs. Affect vs. Mood


  • Other Specified Bipolar and Related Disorder
  • Unspecified Bipolar and Related Disorder
  • Borderline Personality Disorder
  • Attention–Deficit/Hyperactivity Disorder
  • Eating Disorders
  • Posttraumatic Stress Disorder
  • Generalized Anxiety Disorder
  • Panic Disorder
  • Substance Use Disorders
  • Disruptive Mood Dysregulation Disorder
  • Related Conditions
  • (Some) Treatment Resistant Depression
  • Pseudo-Unipolar Depression
  • Atypical Depression


  • Brain
  • The Triune Brain
  • Reptilian Brain
  • Limbic Brain
  • Amygdala
  • Hippocampus
  • Hypothalamus/Pituitary Gland
  • Basal Ganglia
  • Neocortex
  • Peripheral Nervous System
  • Neural Components
  • Communication Systems
  • Hormones
  • Neurotransmitters
  • Biology of Emotion Regulation
  • Brain Regulation
  • Vagal Regulation
  • HPA Regulation


  • Environmental Stress
  • Attachment Theory
  • Epigenetics
  • Chronic Stress Response
  • Neural Effects of Chronic Stress
  • Structural Effects of Chronic Stress
  • Immunologic Effects of Chronic Stress


  • Environmental Treatment
  • Neurofeedback
  • Psychotherapy
  • Medication Treatments
  • Anxiety
  • Benzodiazepine
  • Propranolol
  • Other Medications
  • Depression
  • MAOIs
  • Glutamatergic
  • Other Agents
  • Mood Stabilizers
  • Psychostimulants


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Deborah A. Deliyannides, MD, is Assistant Clinical Professor of Psychiatry at Columbia University College of Physicians and Surgeons, New York, New York and has been a research psychiatrist at the New York State Psychiatric Institute since 1990 where she has worked in the depression research clinic. She maintains private practices in Manhattan, New York, and Darien, Connecticut. Dr. Deliyannides graduated from Jefferson Medical College, Philadelphia, Pennsylvania, and completed her psychiatric residency at the New York Hospital-Cornell Medical Center, New York. She is currently a candidate at the New York University Post Doctoral Program for Psychotherapy and Psychoanalysis in New York City.