Mosquito Gene Drives and the Malaria Eradication Agenda
- Available for pre-order on February 3, 2023. Item will ship after February 24, 2023
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Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene-drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.
Table of Contents
1. Current Scenario of Malaria 2. Transgenesis and Paratransgenesis for the Control of Malaria 3. Gene Drives and Malaria 4. Large Cage Trials of Gene Drive Mosquitoes: Does Size Matter? 5. Field Trial Site Selection for Mosquitoes with Gene Drive: Geographic, Ecological and Population Genetic Considerations 6. Modeling Priorities as Gene Drive Mosquito Projects Transition from Lab to Field 7. Probabilistic Ecological Risk Assessment: An Overview of the Process 8. Community Engagement and Mosquito Gene Drives 9. Review of International and Regulatory Instruments and Processes 10. Gene Drive Mosquitoes: Ethical and Political Considerations
Rebeca Carballar-Lejarazú’s research is focused on insect molecular genetics, vector biology, and the development of synthetic approaches to prevent transmission of mosquito-borne diseases. She has used several genetic strategies such as transposon-based random integration, phiC31 docking-site integration and CRISPR/Cas9 site-specific genome editing technologies to develop transgenic mosquitoes. Dr. Carballar-Lejarazú is currently working on the development, optimization, and evaluation of a CRISPR/Cas9 gene drive system to engineer mosquitoes that resist malaria parasites (population modification/replacement) in two main malaria African vectors Anopheles gambiae and Anopheles coluzzii. Her insect interests have been centered mainly on vector mosquitoes. However, in 2014, she started a collaboration with Professor Sonqing Wu to study biopesticides to control crop pest in China.