Multiparticulate Oral Drug Delivery  book cover
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1st Edition

Multiparticulate Oral Drug Delivery




ISBN 9780367402044
Published September 19, 2019 by CRC Press
496 Pages

 
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Book Description

This definitive reference explores the various aspects of multiparticulate dosage form development-assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms.
Discussing-for the first time in a comprehensive manner-alternative pelletization techniques such as balling (spherical agglomeration), spray congealing, and cryopelletization, Multiparticulate Oral Drug Delivery

  • describes formulation and processing variables that affect the formation, integrity, and performance of coatings derived from molten materials and polymeric solutions and dispersions
  • analyzes the biopharmaceutical aspects and in vivo performance of multiparticulate drug delivery systems
  • details the idiosyncrasies of the manufacturing process of hard-shell gelatin capsules
  • explains the different kinds of packaging materials and machinery and the importance of packaging during the development phase and beyond
  • previews the marketing considerations of multiparticulate systems in the years to come
  • presents practical solutions to problems encountered in the area of film-coating processes
  • and more!
  • Table of Contents

    Manufacture of Core Pellets by Balling
    Preparation of Micropellets by Spray Congealing
    Cryopelletization
    Coating of Multiparticulates Using Polymeric Solutions: Formulation and Process Considerations
    Coating of Multiparticulates Using Polymeric Dispersions: Formulation and Process Considerations
    Coating of Multiparticulates Using Molten Materials: Formulation and Process Considerations,
    Suspensions and Dispersible Dosage Forms of Multiparticulates, Roland Bodmeier and Ornlaksana Paeratakul
    Multiparticulate Encapsulation Equipment and Process
    Compaction of Multiparticulate Oral Dosage Forms
    Key Factors in the Development of Modified-Release Pellets
    Mechanisms of Release from Coated Pellets
    Biopharmaceutical Aspects of Multiparticulates
    In Vivo Behavior of Multiparticulate Versus Single-Unit Dose Formulations
    Capsule Shell Composition and Manufacturing
    Packaging of Multiparticulate Dosage Forms: Materials and Equipment
    Marketing Considerations

    ...
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    Editor(s)

    Biography

    Isaac Ghebre-Sellassie