Multiparticulate Oral Drug Delivery: 1st Edition (Paperback) book cover

Multiparticulate Oral Drug Delivery

1st Edition

Edited by Isaac Ghebre-Selassie

CRC Press

496 pages

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Paperback: 9780367402044
pub: 2019-09-19
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This definitive reference explores the various aspects of multiparticulate dosage form development-assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms.

Discussing-for the first time in a comprehensive manner-alternative pelletization techniques such as balling (spherical agglomeration), spray congealing, and cryopelletization, Multiparticulate Oral Drug Delivery

  • describes formulation and processing variables that affect the formation, integrity, and performance of coatings derived from molten materials and polymeric solutions and dispersions

  • analyzes the biopharmaceutical aspects and in vivo performance of multiparticulate drug delivery systems

  • details the idiosyncrasies of the manufacturing process of hard-shell gelatin capsules

  • explains the different kinds of packaging materials and machinery and the importance of packaging during the development phase and beyond

  • previews the marketing considerations of multiparticulate systems in the years to come

  • presents practical solutions to problems encountered in the area of film-coating processes

  • and more!
  • Table of Contents

    Manufacture of Core Pellets by Balling

    Preparation of Micropellets by Spray Congealing


    Coating of Multiparticulates Using Polymeric Solutions: Formulation and Process Considerations

    Coating of Multiparticulates Using Polymeric Dispersions: Formulation and Process Considerations

    Coating of Multiparticulates Using Molten Materials: Formulation and Process Considerations,

    Suspensions and Dispersible Dosage Forms of Multiparticulates, Roland Bodmeier and Ornlaksana Paeratakul

    Multiparticulate Encapsulation Equipment and Process

    Compaction of Multiparticulate Oral Dosage Forms

    Key Factors in the Development of Modified-Release Pellets

    Mechanisms of Release from Coated Pellets

    Biopharmaceutical Aspects of Multiparticulates

    In Vivo Behavior of Multiparticulate Versus Single-Unit Dose Formulations

    Capsule Shell Composition and Manufacturing

    Packaging of Multiparticulate Dosage Forms: Materials and Equipment

    Marketing Considerations

    About the Editor

    Isaac Ghebre-Sellassie

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Pharmacology
    MEDICAL / Pharmacy
    SCIENCE / Chemistry / General