1st Edition

Multiple Myeloma and Related Disorders

Edited By Gosta Gahrton, Brian Durie, Diana Samson Copyright 2004

    During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes and to gain information about gene expression.

    It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldemström’s macroglobulinaemia, and incorporates both the basic science underlying the diseases and their clinical management. Each chapter has been written to ’stand alone’, allowing the reader to dip into a particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, all of which are considered here, many other approaches to targeted therapy are reviewed.

    Part 1.
          History of multiple myeloma
          Epidemiology and etiology of plasma cell neoplasms
    Part 2.
          The immune system in myeloma
          Molecular biology and cytogenetics
          Biology of the malignant plasma cell
          Pathophysiology of myeloma bone disease
    Part 3.
          Clinical features
          Hematologic investigations: Morphologic and phenotypic
    Part 4.
          Biochemical and immunological investigations
          The role of imaging in multiple myeloma
          Innovative approaches for diagnosis and monitoring
          Differential diagnosis and prognosis
    Part 5.
          Principles of management
          Chemotherapy, steroids and interferon
          Autologous stem cell transplantation
          Allogeneic transplantation and treatment with donor lymphocytes
          Supportive care
          Biological basis of therapy: New molecular targets
          Immunotherapeutic approaches
    Part 6.
          Management of bone disease
          Management of myeloma patients with renal failure
          Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders
    Part 7.
          Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma
          Solitary bone and extramedullary plasmacytoma
          Plasma cell leukaemia
          AL amyloidosis
          Heavy-chain diseases
          Waldenström’s disease


    Gösta Gahrton MD PhD
    Professor, Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden

    Brian G.M. Durie MD
    Attending Physician, Department of Hematology and Oncology, Cedars-Sinai Comprehensive Cancer Centre, Los Angeles, CA, USA

    Diana M. Samson MD
    Senior Lecturer in Haematology, Hammersmith Hospital, London, UK

    The publication of this book...has been well timed in that it offers a benchmark reference for the specialist in this field and provides the nonspecialist with a comprehensive overview of the discipline at the beginning of an exciting new period. A copy of this book should be available in every hematology department and on the shelf of every specialist in this field.

    New England Journal of Medicine

    An impressive list of leaders in the myeloma field has been enrolled in the task to define the state-of-the-art in biology and clinical management of the disease, and the result is a book that is both scientifically sound and user-friendly.
    Annals of Oncology 16:337

    The authors are to be congratulated on this collection of detailed sections, whose logical sequence leads from basic research to the development of new molecular-targeted drugs.
    The Lancet Oncology