This book explores the author’s wide-ranging work on muscle research, which spans more than 50 years. It delves into the dogmas of muscle contraction: how the models were constructed and what was overlooked during the process, including their resulting shortcomings. The text stimulates general readers’ and researchers’ interest, highlights the author’s pioneering work on the electron microscopic recording of myosin head power and recovery strokes, and presents a frank discussion on how the original work sometimes tends to be overlooked by competing scientists, who hinder the progress of science.
Table of Contents
Dogmas of Huxley-Simmons Model not Supported Experimentally
New Methods and New Dogmas and Their Shortcomings
The Swinging Lever Arm Hypothesis: A Most Prominent Current Dogma
Dynamic Electron Microscopy on Myosin Head Movement Using Quick-Freeze, Deep-Etch Replica Method
Electron Microscopic Recording of ATP-Induced Myosin Head Movement
Evidence against Current Dogmas of Muscle Contraction as Revealed by the Effect of Antibodies to Myosin Head
Electron Microscopic Recording of Myosin Head Power Stroke: Possible Sequence of Actin-Myosin Interaction in Muscle
The Fenn Effect : A Fundamental Mystery in Muscle
Load-Dependent Mechanical Efficiency of Myosin Heads
Past History Dependence of Myosin Head Performance
Reminiscences of My Early Work I. Summation of Force Responses in Muscle
Reminiscences of My Early Work II. Transverse Spread of Contraction Initiated by Local Membrane Depolarization in Single Muscle Fibers
Haruo Sugi was appointed instructor in the Department of Physiology of the University of Tokyo, Japan, in 1962 and worked at Columbia University and the National Institutes of Health, USA, from 1965 to 1967. He was a professor in and chair of the Department of Physiology, Teikyo University Medical School, Japan, from 1973 to 2004, when he became emeritus professor. Prof. Sugi organized international symposia on muscle contraction six times from 1978 to 2004 and has edited three books. From 1995 to 2005, he was chair of the Muscle Commission in the International Union of Physiological Sciences.