NMR Spectroscopy in Liquids and Solids  book cover
1st Edition

NMR Spectroscopy in Liquids and Solids

ISBN 9781482262704
Published April 10, 2015 by CRC Press
360 Pages - 143 B/W Illustrations

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Book Description

NMR Spectroscopy in Liquids and Solids provides an introduction of the general concepts behind Nuclear Magnetic Resonance (NMR) and its applications, including how to perform adequate NMR experiments and interpret data collected in liquids and solids to characterize molecule systems in terms of their structure and dynamics.

The book is composed of ten chapters. The first three chapters consider the theoretical basis of NMR spectroscopy, the theory of NMR relaxation, and the practice of relaxation measurements. The middle chapters discuss the general aspects of molecular dynamics and their relationships to NMR, NMR spectroscopy and relaxation studies in solutions, and special issues related to NMR in solutions.

The remaining chapters introduce general principles and strategies involved in solid-state NMR studies, provide examples of applications of relaxation for the determination of molecular dynamics in diamagnetic solids, and discuss special issues related to solid state NMR— including NMR relaxation in paramagnetic solids.

All chapters are accompanied by references and recommended literature for further reading. Many practical examples of multinuclear NMR and relaxation experiments and their interpretations are also presented. The book is ideal for scientists new to NMR, students, and investigators working in the areas of chemistry, biochemistry, biology, pharmaceutical sciences, or materials science.

Table of Contents

Physical Basis of Nuclear Magnetic Resonance
Nuclei in the External Magnetic Field
Radio-frequency Irradiation: Continuous Wave and Radio-frequency Pulses
From Nuclear Relaxation to Shapes of NMR Signals
Registration of NMR Signals: General Principles and NMR Equipment
Enhancement of Sensitivity in NMR Experiments
Two-Dimensional and Multi-Quantum NMR Experiments: General Aspects
References and Recommended Literature

Chemical Shift and Nuclear Coupling

Theory and Practical Consequences
Phenomenology of Chemical Shift
Chemical Shifts in the Presence of Unpaired Electrons
Spin-Spin Coupling
Dipolar Coupling
Quadrupolar Coupling
References and Recommended Literature

Nuclear Relaxation: Theory and Measurements

Molecular Motions: Common Characteristics
Mechanisms of Spin-Spin and Spin-Lattice Nuclear Relaxation
Spin Diffusion in Solids
Paramagnetic Relaxation
Relaxation Time Measurements
Experiments and Measurements: Errors, Problems, and Artifacts
Artifacts in Relaxation Time Measurements
References and Recommended Literature

NMR and Molecular Dynamics: General Principles

Kinetics of Chemical Reactions by NMR Spectroscopy
Chemical Exchange
Molecular Mobility from Relaxation Times
NMR Relaxometry: Diffusion Coefficients
Molecular Dynamics from Low-Field NMR
References and Recommended Literature

NMR Spectroscopy in Solutions: Practice
and Strategies of Structural Studies
Preparation of NMR Samples: Minimal Requirements
Structural Studies by Solution NMR: General Strategies and 1D and 2D NMR Experiments
Conformational (Isomeric) Analysis by NMR in Solutions
NOE and Residual Dipolar Coupling Measurements in Structural Studies
References and Recommended Literature

NMR Relaxation in Solutions: Applications
Partially Relaxed NMR Spectra: Resolving the Unresolved Signals and Assigning NMR Signals
Relaxation Times in Solutions: Quadrupolar Coupling Constants and Chemical Shift Anisotropy
NMR Relaxation and Intermolecular Interactions
Solvent Relaxation
Relaxation in Molecular Systems with Chemical Exchanges
Structural Aspects Obtained from Relaxation in Solutions
References and Recommended Literature

Solution NMR: Special Issues

Optical Isomers in NMR Spectra
Solution NMR of Biomolecules: General Principles
Dynamics in Liquids by NMR
para-Hydrogen and NMR Spectroscopy in Solutions
Solution NMR Spectroscopy and Heterogeneous Molecular Systems
Free Radicals in NMR Spectra of Solutions
References and Recommended Literature

Solid-State NMR Spectroscopy: General Principles and Strategies

Detection of NMR Signals in Solids
General Approaches and Strategies of NMR Studies in Solids
Increasing Spectral Resolution in Solid-State NMR
Assignments of Signals
Multinuclear Solid-State NMR Applications
References and Recommended Literature

Molecular Dynamics and Nuclear
Relaxation in Solids: Applications
Temperature Control and Calibration in Solid-State NMR
Unusually Fast Molecular Dynamics in Solids
Molecular Dynamics in Solids Determined by Full Line-Shape Analysis
One- and Two-Dimensional Exchange NMR Spectroscopy in Solids: Slow Molecular Dynamics
Dynamics in Solids by Cross-Polarization NMR Experiments
Molecular Dynamics in Solids by NMR Relaxation
Measurements: Common Aspects of Applications
Dynamics in Heterogeneous and Disordered Solids: NMR Spectra and Relaxation Dispersion
Dynamics in Solids under High Pressure
References and Recommended Literature

Solid-State NMR: Special Issues

Solid-State NMR of Proteins
Solid-State NMR in Metals and Alloys
Porous Diamagnetic Solids: Porosity via NMR Experiments
Solid-State NMR and Paramagnetic Molecular Systems
Nuclear Relaxation in Paramagnetic Solids: Applications
References and Recommended Literature

Concluding Remark

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Vladimir I. Bakhmutov works in the Department of Chemistry at Texas A&M University in College Station. He earned his PhD in physical inorganic chemistry from Moscow State University. Dr. Bakhmutov’s research interests include extensive applications of solution and solid state NMR techniques for chemistry, molecular physics, and materials science. Dr. Bakhmutov has been granted visiting professorships by Zurich University, Switzerland; Bourgogne University, Dijon, France; Rennes University, France; CINVESTAV, Mexico; and Iberdrola, Zaragosa, Spain. He is the author or co-author of more than 300 scientific articles and five books.


"…a valuable and comprehensive introduction to general concepts behind NMR spectroscopy and a condense overview illustrating the multiple facets of NMR applications in various analytical domains. …compared with the existing literature, this book proposes various insights on unusual NMR topics. From this aspect, it is therefore a worthwhile addition to any up-to-date NMR library."
—Philippe Lesot, in Analytical and Bioanalytical Chemistry

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