NMR Spectroscopy in Liquids and Solids: 1st Edition (Paperback) book cover

NMR Spectroscopy in Liquids and Solids

1st Edition

By Vladimir I. Bakhmutov

CRC Press

360 pages | 143 B/W Illus.

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Description

NMR Spectroscopy in Liquids and Solids provides an introduction of the general concepts behind Nuclear Magnetic Resonance (NMR) and its applications, including how to perform adequate NMR experiments and interpret data collected in liquids and solids to characterize molecule systems in terms of their structure and dynamics.

The book is composed of ten chapters. The first three chapters consider the theoretical basis of NMR spectroscopy, the theory of NMR relaxation, and the practice of relaxation measurements. The middle chapters discuss the general aspects of molecular dynamics and their relationships to NMR, NMR spectroscopy and relaxation studies in solutions, and special issues related to NMR in solutions.

The remaining chapters introduce general principles and strategies involved in solid-state NMR studies, provide examples of applications of relaxation for the determination of molecular dynamics in diamagnetic solids, and discuss special issues related to solid state NMR— including NMR relaxation in paramagnetic solids.

All chapters are accompanied by references and recommended literature for further reading. Many practical examples of multinuclear NMR and relaxation experiments and their interpretations are also presented. The book is ideal for scientists new to NMR, students, and investigators working in the areas of chemistry, biochemistry, biology, pharmaceutical sciences, or materials science.

Reviews

"…a valuable and comprehensive introduction to general concepts behind NMR spectroscopy and a condense overview illustrating the multiple facets of NMR applications in various analytical domains. …compared with the existing literature, this book proposes various insights on unusual NMR topics. From this aspect, it is therefore a worthwhile addition to any up-to-date NMR library."

—Philippe Lesot, in Analytical and Bioanalytical Chemistry

Table of Contents

Physical Basis of Nuclear Magnetic Resonance

Nuclei in the External Magnetic Field

Radio-frequency Irradiation: Continuous Wave and Radio-frequency Pulses

From Nuclear Relaxation to Shapes of NMR Signals

Registration of NMR Signals: General Principles and NMR Equipment

Enhancement of Sensitivity in NMR Experiments

Two-Dimensional and Multi-Quantum NMR Experiments: General Aspects

References and Recommended Literature

Chemical Shift and Nuclear Coupling

Theory and Practical Consequences

Phenomenology of Chemical Shift

Chemical Shifts in the Presence of Unpaired Electrons

Spin-Spin Coupling

Dipolar Coupling

Quadrupolar Coupling

References and Recommended Literature

Nuclear Relaxation: Theory and Measurements

Molecular Motions: Common Characteristics

Mechanisms of Spin-Spin and Spin-Lattice Nuclear Relaxation

Spin Diffusion in Solids

Paramagnetic Relaxation

Relaxation Time Measurements

Experiments and Measurements: Errors, Problems, and Artifacts

Artifacts in Relaxation Time Measurements

References and Recommended Literature

NMR and Molecular Dynamics: General Principles

Kinetics of Chemical Reactions by NMR Spectroscopy

Chemical Exchange

Molecular Mobility from Relaxation Times

NMR Relaxometry: Diffusion Coefficients

Molecular Dynamics from Low-Field NMR

References and Recommended Literature

NMR Spectroscopy in Solutions: Practice and Strategies of Structural Studies

Preparation of NMR Samples: Minimal Requirements

Structural Studies by Solution NMR: General Strategies and 1D and 2D NMR Experiments

Conformational (Isomeric) Analysis by NMR in Solutions

NOE and Residual Dipolar Coupling Measurements in Structural Studies

References and Recommended Literature

NMR Relaxation in Solutions: Applications

Partially Relaxed NMR Spectra: Resolving the Unresolved Signals and Assigning NMR Signals

Relaxation Times in Solutions: Quadrupolar Coupling Constants and Chemical Shift Anisotropy

NMR Relaxation and Intermolecular Interactions

Solvent Relaxation

Relaxation in Molecular Systems with Chemical Exchanges

Structural Aspects Obtained from Relaxation in Solutions

References and Recommended Literature

Solution NMR: Special Issues

Optical Isomers in NMR Spectra

Solution NMR of Biomolecules: General Principles

Dynamics in Liquids by NMR

para-Hydrogen and NMR Spectroscopy in Solutions

Solution NMR Spectroscopy and Heterogeneous Molecular Systems

Free Radicals in NMR Spectra of Solutions

References and Recommended Literature

Solid-State NMR Spectroscopy: General Principles and Strategies

Detection of NMR Signals in Solids

General Approaches and Strategies of NMR Studies in Solids

Increasing Spectral Resolution in Solid-State NMR

Assignments of Signals

Multinuclear Solid-State NMR Applications

References and Recommended Literature

Molecular Dynamics and Nuclear Relaxation in Solids: Applications

Temperature Control and Calibration in Solid-State NMR

Unusually Fast Molecular Dynamics in Solids

Molecular Dynamics in Solids Determined by Full Line-Shape Analysis

One- and Two-Dimensional Exchange NMR Spectroscopy in Solids: Slow Molecular Dynamics

Dynamics in Solids by Cross-Polarization NMR Experiments

Molecular Dynamics in Solids by NMR Relaxation

Measurements: Common Aspects of Applications

Dynamics in Heterogeneous and Disordered Solids: NMR Spectra and Relaxation Dispersion

Dynamics in Solids under High Pressure

References and Recommended Literature

Solid-State NMR: Special Issues

Solid-State NMR of Proteins

Solid-State NMR in Metals and Alloys

Porous Diamagnetic Solids: Porosity via NMR Experiments

Solid-State NMR and Paramagnetic Molecular Systems

Nuclear Relaxation in Paramagnetic Solids: Applications

References and Recommended Literature

Concluding Remark

About the Author

Vladimir I. Bakhmutov works in the Department of Chemistry at Texas A&M University in College Station. He earned his PhD in physical inorganic chemistry from Moscow State University. Dr. Bakhmutov’s research interests include extensive applications of solution and solid state NMR techniques for chemistry, molecular physics, and materials science. Dr. Bakhmutov has been granted visiting professorships by Zurich University, Switzerland; Bourgogne University, Dijon, France; Rennes University, France; CINVESTAV, Mexico; and Iberdrola, Zaragosa, Spain. He is the author or co-author of more than 300 scientific articles and five books.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI043000
SCIENCE / Research & Methodology
SCI078000
SCIENCE / Spectroscopy & Spectrum Analysis